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Francesco Forconi
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Journal Articles

The origin, diagnosis, and prognosis of oligomannose-type diffuse large B-cell lymphoma

Available to Purchase
Dylan J. Tatterton, Maddy L. Newby, Joel D. Allen, Benjamin Sale, Giorgia Chiodin, Patrick J. Duriez, John Butler, Katy J. McCann, David W. Scott, Ryan D. Morin, Kostiantyn Dreval, Andrew J. Davies, Dean J. Bryant, Max Crispin, Francesco Forconi
Journal: Blood
Blood (2025) 146 (23): 2808–2820.
https://doi.org/10.1182/blood.2025029163
Published: 2025
Includes: Supplemental data
Journal Articles

Ibrutinib plus rituximab leads to superior progression-free and overall survival to FCR in previously untreated CLL: Results of the Phase III NCRI FLAIR trial

Free
Talha Munir, Sean Girvan, Annah Muli, David Cairns, David Allsup, Adrian Bloor, Abraham Mullasseril Varghese, Angus Broom, Moya Young, Ben Kennedy, Renata Walewska, Michelle Furtado, Gavin Preston, Jeffrey Neilson, Nicholas Pemberton, Gamal Sidra, Nick Morley, Kate Cwynarski, Toby Eyre, Francesco Forconi, Simona Gatto, Shankara Paneesha, Christopher Fox, Dena Howard, Anna Hockaday, Julia Brown, Sharon Jackson, David Stones, Sue Bell, Natasha Greatorex, Nichola Webster, Jane Shingles, Surita Dalal, Piers Patten, Andy Rawstron, Peter Hillmen
Journal: Blood
Blood (2025) 146 (Supplement 1): 2128.
https://doi.org/10.1182/blood-2025-2128
Published: 2025
Journal Articles

Bexobrutideg (NX-5948), a novel Bruton's tyrosine kinase (BTK) degrader, demonstrates rapid and durable clinical responses in Relapsed/Refractory chronic lymphocytic leukemia (CLL): New and updated findings from an ongoing Phase 1a/b trial

Free
Zulfa Omer, Alexey Danilov, Francesco Forconi, Talha Munir, Mary Gleeson, Nirav Shah, Graham Collins, Alvaro Alencar, Jane Robertson, Jonathon Cohen, Karan Dixit, Danielle Brander, John Byrd, Allison Winter, Jeffery Smith, Dima El-Sharkawi, Michal Kwiatek, Iwona Hus, Prioty Islam, Sebastian Grosicki, Michael Tees, Thorsten Zenz, Joanna Romejko-Jarosinska, Sarah Injac, Wojciech Jurczak
Journal: Blood
Blood (2025) 146 (Supplement 1): 86.
https://doi.org/10.1182/blood-2025-86
Published: 2025
Journal Articles

Integrated multi-omic profiling reveals two biologically distinct subgroups of splenic marginal zone lymphoma with prognostic relevance

Free
Helen Parker, Ben Stevens, Amatta Mirandari, Carolina Jaramillo-Oquendo, Marti Duran-ferrer, Lara Buermann, Harindra Amarasinghe, Jaya Thomas, Louise Carr, Shama Syeda, Methusha Sakthipakan, Marina Parry, Matthew Rose-Zerilli, Zadie Davis, Neil McIver-Brown, Aliki Xochelli, Sarah Ennis, Lydia Scarfo, Paolo Ghia, Christina Kalpadakis, Gerassimos Pangalis, Davide Rossi, Matthew Ahearne, Marc PD Dr. Seifert, Christoph Plass, Dieter Weichenhan, Eva Kimby, Lesley Ann Sutton, Richard Rosenquist, Guy Pratt, Francesco Forconi, Kostas Stamatopoulos, Marta Salido, Raja Prince-Eladnani, Catherine Thieblemont, Laura Hilton, Ryan Morin, Renata Walewska, Jose Martin-Subero, David Oscier, Christopher Oakes, Jane Gibson, Dean Bryant, Jonathan Strefford
Journal: Blood
Blood (2025) 146 (Supplement 1): 353.
https://doi.org/10.1182/blood-2025-353
Published: 2025
Journal Articles

IGHV Unmutated Status, Low Tumor Lysis Risk Disease and BRAF Mutated Status Are Predictors for Early MRD Responders Treated with MRD Defined Ibrutinib with Venetoclax: Report of the UK NCRI FLAIR Study

Free
Talha Munir, Abraham Mullasseril Varghese, Adrian Bloor, David Allsup, Kate Cwynarski, Andrew Pettitt, Shankara Paneesha, Christopher P Fox, Toby A. Eyre, Francesco Forconi, Nagah Elmusharaf, Ben Kennedy, Prof. John G. Gribben, Nicholas Pemberton, Oonagh Sheehy, Gavin Preston, Anna Schuh, Anna Hockaday, David A. Cairns, Sharon Jackson, Natasha Greatorex, Sean Girvan, Sue Bell, David Stones, Nichola McWhirter, Surita Dalal, Andrew Rawstron, Piers Patten, Peter Hillmen
Journal: Blood
Blood (2024) 144 (Supplement 1): 585.
https://doi.org/10.1182/blood-2024-211449
Published: 2024
Journal Articles

Single-Cell Transcriptional Characteristics of the Unresponsive Cluster Surviving Anergy in IGHV1-69 CLL

Free
Stuart Lanham, Luis Del Rio Fernandez, Stefano de Pretis, Joshua Grant, Isla Henderson, Benjamin Sale, Lauren Griffith, David Dutton, Giovanni Tonon, Freda K. Stevenson, Francesco Forconi
Journal: Blood
Blood (2024) 144 (Supplement 1): 1847.
https://doi.org/10.1182/blood-2024-210464
Published: 2024
Journal Articles

Efficacy and Safety of the Bruton's Tyrosine Kinase (BTK) Degrader NX-5948 in Patients with Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL): Updated Results from an Ongoing Phase 1a/b Study

Free
Nirav N. Shah, Zulfa Omer, Graham P. Collins, Francesco Forconi, Alexey Danilov, John C. Byrd, Dima El-Sharkawi, Emma Searle, Alvaro J Alencar, Shuo Ma, Sarah Injac, Talha Munir
Journal: Blood
Blood (2024) 144 (Supplement 1): 884.
https://doi.org/10.1182/blood-2024-194839
Published: 2024
Journal Articles

Time for a new prognostic score in CLL?

Free
Clinical Trials & Observations
Francesco Forconi
Journal: Blood
Blood (2024) 143 (25): 2561–2562.
https://doi.org/10.1182/blood.2024024877
Published: 2024
Journal Articles

The essential microenvironmental role of oligomannoses specifically inserted into the antigen-binding sites of lymphoma cells

Free
Freda K. Stevenson, Francesco Forconi
Journal: Blood
Blood (2024) 143 (12): 1091–1100.
https://doi.org/10.1182/blood.2023022703
Published: 2024
Journal Articles

DNA Methylation-Based Classification of Hairy Cell Leukemia and Splenic B Cell Lymphoma

Free
Kyoko Yamaguchi, Salma Abdelbaky, Evgeny Arons, Matthew Cross, Yue-Zhong Wu, Christoph Weigel, Mirela Iulia Anghelina, Helen Parker, Artur Kibler, Marta Salido, Constance Regina Baer, Manja Meggendorfer, Benjamin Durham, Omar Abdel-Wahab, Seema A Bhat, Gerard Lozanski, Kerry A Rogers, Yonghong Wang, Paul S. Meltzer, Sunil Iyengar, Sascha Dietrich, Thorsten Zenz, James S. Blachly, Aurelie Verney, Lucile Baseggio, Alexandra Traverse-Glehen, Marc Seifert, Ralf Kuppers, Richard Burack, Clive S Zent, Versha Banerji, James B. Johnston, David Graham Oscier, Renata Walewska, Kostas Stamatopoulos, Torsten Haferlach, Ana Ferrer, Catherine Thieblemont, Francesco Forconi, Robert Kreitman, Michael R. Grever, Jonathan C. Strefford, Piers Blombery, Christopher C. Oakes
Journal: Blood
Blood (2023) 142 (Supplement 1): 174.
https://doi.org/10.1182/blood-2023-189835
Published: 2023
Journal Articles

Initial Findings from a First-in-Human Phase 1a/b Trial of NX-5948, a Selective Bruton's Tyrosine Kinase (BTK) Degrader, in Patients with Relapsed/Refractory B Cell Malignancies

Free
Emma Searle, Francesco Forconi, Kim Linton, Alexey Danilov, Pam McKay, David Lewis, Dima El-Sharkawi, Mary Gleeson, John Riches, Sarah G. Injac, Ted Shih, Srinand Nandakumar, May Tan, Ganesh Cherala, Erin Meredith, Graham P. Collins
Journal: Blood
Blood (2023) 142 (Supplement 1): 4473.
https://doi.org/10.1182/blood-2023-179508
Published: 2023
Journal Articles

Selinexor Enhances Natural Killer Cell Function Against Multiple Myeloma Cells

Free
Jack G Fisher, Amber DP Doyle, Lara V Graham, Francesco Forconi, Mark S Cragg, Christopher J Walker, Salim I Khakoo, Matthew D Blunt
Journal: Blood
Blood (2023) 142 (Supplement 1): 6599.
https://doi.org/10.1182/blood-2023-179744
Published: 2023
Journal Articles

The Proliferative History Index, Epicmit, Derived from Genome-Wide Epigenomic Profiling, Is a Key Driver of Clinical Survival in Splenic Marginal Zone Lymphoma

Free
Helen Parker, Amatta Mirandari, Carolina Jaramillo-Oquendo, Marti Duran-Ferrer, Ben Stevens, Lara Buermann, Harindra Eranthi Amarasinghe, Jaya Thomas, Louise J. Carr, Shama Syeda, Methusha Sakthipakan, Marina Parry, Zadie Davies, Neil McIver-Brown, Aliki Xochelli, Sarah Ennis, Lydia Scarfo, Paolo Ghia, Christina H. Kalpadakis, Gerassimos Pangalis, Davide Rossi, Simon Wagner, Matthew Ahearne, Marc Seifert, Christoph Plass, Dieter Weichenhan, Eva Kimby, Lesley Ann Sutton, Richard Rosenquist, Francesco Forconi, Kostas Stamatopoulos, Marta Salido, Ana Ferrer, Catherine Thieblemont, David Graham Oscier, Renata Walewska, Matthew JJ Rose-Zerilli, Jane Gibson, Iñaki I. Martin Subero, Christopher C. Oakes, Dean J. Bryant, Jonathan C. Strefford
Journal: Blood
Blood (2023) 142 (Supplement 1): 4370.
https://doi.org/10.1182/blood-2023-174481
Published: 2023
Journal Articles

Oligomannose-Type Glycans in the Antigen Binding Site Identify Origin and Prognosis of Diffuse Large B Cell Lymphoma

Free
Dylan J. Tatterton, Benjamin Sale, Joel Allen, Maddy L. Newby, Giorgia Chiodin, Patrick J. Duriez, John Butler, Katy J. McCann, David W. Scott, Ryan Morin, Andrew S. Davies, Dean J. Bryant, Freda K. Stevenson, Max Crispin, Francesco Forconi
Journal: Blood
Blood (2023) 142 (Supplement 1): 428.
https://doi.org/10.1182/blood-2023-188721
Published: 2023
Journal Articles

Ibrutinib Plus Venetoclax with MRD-Directed Duration of Treatment Is Superior to FCR and Is a New Standard of Care for Previously Untreated CLL: Report of the Phase III UK NCRI FLAIR Study

Free
Peter Hillmen, David Allan Cairns, Adrian John Clifton Bloor, David Allsup, Kate Cwynarski, Andrew Pettitt, Shankaranarayana Paneesha, Christopher P. Fox, Toby A. Eyre, Francesco Forconi, Nagah Elmusharaf, Ben Kennedy, John G. Gribben, Nicholas Pemberton, Oonagh Sheehy, Gavin Preston, Anna Schuh, Dena Howard, Anna Hockaday, Sharon Jackson, Natasha Greatorex, Sean Girvan, Sue Bell, Julia Brown, Nichola Webster, Surita Dalal, Ruth M de Tute, Andrew Rawstron, Piers EM Patten, Talha Munir
Journal: Blood
Blood (2023) 142 (Supplement 1): 631.
https://doi.org/10.1182/blood-2023-178298
Published: 2023
Journal Articles

Analysis of Single B Cells Reveals a Double Drive of Endocytosis and Transcriptional Downregulation Acting on the CLL B-Cell Receptor In Vivo

Free
Stuart Lanham, Luis Del Rio Fernandez, Joshua Grant, Isla Henderson, Ben Sale, Dean J. Bryant, Lauren Griffith, Alberto Orfao, Freda K. Stevenson, Francesco Forconi
Journal: Blood
Blood (2023) 142 (Supplement 1): 6508.
https://doi.org/10.1182/blood-2023-188571
Published: 2023
Journal Articles

Combination of Ibrutinib Plus Venetoclax with MRD-Driven Duration of Treatment Results in a Higher Rate of MRD Negativity in IGHV Unmutated Than Mutated CLL: Updated Interim Analysis of FLAIR Study

Free
Talha Munir, Alexandra Pitchford, Adrian Bloor, Andrew Pettitt, Piers E.M. Patten, Francesco Forconi, Anna Schuh, Christopher P Fox, Simona Gatto, Ben Kennedy, John Gribben, Nicholas Pemberton, Oonagh Sheehy, Gavin Preston, Dena Howard, Anna Hockaday, David Cairns, Sharon Jackson, Natasha Greatorex, Nichola McWhirter, Jane Shingles, Kate Cwynarski, Shankara Paneesha, David Allsup, Andrew Rawstron, Peter Hillmen
Journal: Blood
Blood (2022) 140 (Supplement 1): 231–233.
https://doi.org/10.1182/blood-2022-170463
Published: 2022
Journal Articles

MRD4 Eradication at 6 Months and Early Clearance of MRD with Combination of Ibrutinib Plus Venetoclax Results in Sustained Clinical and MRD Responses: Exploratory Analysis of the Blood Cancer UK TAP Clarity Study

Free
Talha Munir, Louise-Rae Cherrill, Nichola Webster, Surita Dalal, Rebecca H. Boucher, Chhaya Sankhalpara, Francesca Yates, Sonia Fox, Donald Macdonald, Christopher Fegan, Alison McCaig, Anna Schuh, Andrew Pettitt, John G. Gribben, Piers E.M. Patten, Stephen Devereux, Adrian Bloor, Christopher P Fox, Francesco Forconi, Andy C. Rawstron, Peter Hillmen
Journal: Blood
Blood (2022) 140 (Supplement 1): 222–223.
https://doi.org/10.1182/blood-2022-166700
Published: 2022
Journal Articles

DC-SIGN Binding to the Oligomannose-Type Glycans on the Surface Immunoglobulin Variable Region of Follicular Lymphoma Promotes Selective Adhesion to Microenvironmental VCAM-1

Free
Giorgia Chiodin, Dylan Tatterton, Patrick J Duriez, Ayse Ertay, Philip J Rock, Benjamin Sale, Stuart Lanham, Luis Del Rio, Carl Figdor, Richard Burack, Freda K Stevenson, Francesco Forconi
Journal: Blood
Blood (2022) 140 (Supplement 1): 6460–6461.
https://doi.org/10.1182/blood-2022-169647
Published: 2022
Journal Articles

EMT-like Activation in CLL Provides Novel Therapeutic Target

Free
Charlott Repschlaeger, Mariette Odabashian, Filomena Spada, Zamzam Almutairi, John G. Gribben, Francesco Forconi, Emre Sayan, Alexessander Couto Alves, Charline Giroud, Oleg Fedorov, Marina Kriajevskaia, Sergey Krysov
Journal: Blood
Blood (2022) 140 (Supplement 1): 12375–12376.
https://doi.org/10.1182/blood-2022-162696
Published: 2022