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Journal Articles

Ibrutinib plus rituximab leads to superior progression-free and overall survival to FCR in previously untreated CLL: Results of the Phase III NCRI FLAIR trial

Free
Talha Munir, Sean Girvan, Annah Muli, David Cairns, David Allsup, Adrian Bloor, Abraham Mullasseril Varghese, Angus Broom, Moya Young, Ben Kennedy, Renata Walewska, Michelle Furtado, Gavin Preston, Jeffrey Neilson, Nicholas Pemberton, Gamal Sidra, Nick Morley, Kate Cwynarski, Toby Eyre, Francesco Forconi, Simona Gatto, Shankara Paneesha, Christopher Fox, Dena Howard, Anna Hockaday, Julia Brown, Sharon Jackson, David Stones, Sue Bell, Natasha Greatorex, Nichola Webster, Jane Shingles, Surita Dalal, Piers Patten, Andy Rawstron, Peter Hillmen
Journal: Blood
Blood (2025) 146 (Supplement 1): 2128.
https://doi.org/10.1182/blood-2025-2128
Published: 2025
Journal Articles

Encouraging long-term efficacy and safety from first-in-human phase 1 study of time-limited NVG-111 in relapsed/refractory CLL and MCL

Free
William Townsend, Sarah Leong, Mittal Shah, Toby Batten, David Tucker, Bryson Pottinger, Shankara Paneesha, Dima El-Sharkawi, David Granger, Kieran O'Donovan, Amit Nathwani, Parag Jasani
Journal: Blood
Blood (2025) 146 (Supplement 1): 2125.
https://doi.org/10.1182/blood-2025-2125
Published: 2025
Journal Articles

Initial results of a CRUK phase I/II, first in human trial of the CAR t-cell engager protein aleta-001 in patients who have received anti-CD19 CAR t-cell therapy for the treatment of b-cell malignancies

Free
Sridhar Chaganti, William Townsend, Bernard Maybury, Shankara Paneesha, Victoria Peacock, Alice Feast, Ram Malladi, Ben Uttenthal, Cathy Burton, Mary Owen, Adam Gibb, Jane Norman, Sunil Iyengar, Adrian Shields, Saly Al-Taei, Gareth Veal, Lucia Gargiulo, Jenny Craigen, Alka Lal, Emma Anderton, Aikaterini Lalatsa, Lisa Loram, Marco Schupp, Gary Acton, Paul Rennert
Journal: Blood
Blood (2025) 146 (Supplement 1): 925.
https://doi.org/10.1182/blood-2025-925
Published: 2025
Journal Articles

Outcomes of allogeneic hematopoietic stem cell transplantation in nodular lymphocyte-predominant Hodgkin lymphoma: A registry-based study from the EBMT-LWP

Free
Maria Carmen Martinez Munoz, Mathilde Fekom, Regis Peffault De Latour, Arian Laurence, Anne Huynh, Maija Itälä-Remes, Edouard Forcade, Emanuele Angelucci, Shankara Paneesha, Francesca Kinsella, Sebastian Giebel, Peter Pal Remenyi, Gaëlle Guillerm, Renato Fanin, Alexander Kulagin, Victoria Potter, Emma Nicholson, Didier Blaise, Husam Abu-Jazar, Selami Koçak Toprak, Soledad GONZALEZ Muñiz, Grzegorz Helbig, Alina Tanase, Anna Sureda Balarí, Ali Bazarbachi
Journal: Blood
Blood (2025) 146 (Supplement 1): 1842.
https://doi.org/10.1182/blood-2025-1842
Published: 2025
Journal Articles

Analysis of immune parameters and effect of immunoglobulin replacement therapy on infection, survival and non-relapse mortality following CD19 CAR T-cell therapy

Free
Vaishali Dulobdas, Amy Kirkwood, Brijesh Gautama, Shenbagaram Kasivisvanathan, Vismaykumar Deshani, Amrith Mathew, Robert Wilson, Ram Malladi, Jane Norman, Lindsay George, Nikesh Chavda, Caroline Besley, Ben Uttenthal, Shankara Paneesha, Bernard Maybury, Adrian Shields, Sridhar Chaganti
Journal: Blood
Blood (2025) 146 (Supplement 1): 714.
https://doi.org/10.1182/blood-2025-714
Published: 2025
Journal Articles

Outcomes of autologous hematopoietic stem cell transplantation in nodular lymphocyte-predominant Hodgkin lymphoma: A registry-based study from the EBMT-LWP

Free
Maria Carmen Martinez Munoz, Mathilde Fekom, Anne Huynh, Khalid Halahleh, Ashrafsadat Mousavi, Matthias Stelljes, John Gribben, Yasmina Serroukh, Sebastian Giebel, Christof Scheid, Carin Hazenberg, Gaëlle Guillerm, Marie-Thérèse Rubio, Jan Walewski, Michael Daskalakis, Andrew Peniket, Damian Finnegan, Shankara Paneesha, Francesca Kinsella, Pavel Jindra, Binyam Usman, Anne Banos, Alina Tanase, Anna Sureda Balarí, Ali Bazarbachi
Journal: Blood
Blood (2025) 146 (Supplement 1): 3620.
https://doi.org/10.1182/blood-2025-3620
Published: 2025
Journal Articles

Tafasitamab Plus Lenalidomide and Rituximab for Relapsed or Refractory Follicular Lymphoma: Results from a Phase 3 Study (inMIND)

Free
Laurie H. Sehn, Stefano Luminari, Christian W. Scholz, Kai Hübel, Antonio Salar, Shankara Paneesha, Bjorn E Wahlin, Panayiotis Panayiotidis, Hui-Peng Lee, Ana Jiménez Ubieto, Juan-Manuel Sancho, Tae Min Kim, Eva Domingo Domenech, Takahiro Kumode, Christina Poh, Catherine Thieblemont, Dries Deeren, Edwin de Wit, Michael Arbushites, Marie-Laure Casadebaig, Marek Trneny
Journal: Blood
Blood (2024) 144 (Supplement 2): LBA-1.
https://doi.org/10.1182/blood-2024-212970
Published: 2024
Journal Articles

Improved Outcomes in Paroxysmal Nocturnal Hemoglobinuria Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation in 2011-2020: A Retrospective EBMT-Saawp Study

Free
Camilla Frieri, Dirk-Jan Eikema, Sr., Joe Tuffnell, Brian Piepenbroek, Malek Benakli, Grzegorz Helbig, Thomas Cluzeau, Cécile Renard, Philippe Lewalle, Victoria Potter, Krzysztof Kalwak, Sr., Johan Maertens, Gerard Michel, Andrew Bruce McDonald, Péter Pál Reményi, Ladislav Sopko, Kazimierz Halaburda, Depei Wu, Zubeyde Nur Ozkurt, Xavier Poiré, Morag Griffin, Mahmoud Aljurf, Ashrafsadat Mousavi, Jose Antonio Pérez-Simón, Henrik Sengeloev, Ben Carpenter, Eric Deconinck, Arancha Bermúdez, Stéphanie Nguyen-Quoc, Matteo Parma, Ibrahim Yakoub-Agha, Shankara Paneesha, Lutz Peter Hermann Mueller, Regis Peffault De Latour, Austin G. Kulasekararaj, Antonio M Risitano
Journal: Blood
Blood (2024) 144 (Supplement 1): 305.
https://doi.org/10.1182/blood-2024-194716
Published: 2024
Journal Articles

Outcome of Hematopoietic Stem Cell Transplantation for Follicular Lymphoma, a Benchmark Study from the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation

Free
Yasmina I.M. Serroukh, Mathilde Fekom, Irma Khvedelidze, Ben Carpenter, Herve Ghesquieres, Ludovic Gabellier, Jacques-Olivier Bay, Didier Blaise, Maurizio Musso, Patrice Chevallier, Edouard Forcade, Anne Huynh, Andy Peniket, Marek Trněný, Catherine Flynn, Shankara Paneesha, Andrew Clark, Charalampia Kyriakou, Anna Ossami Saidy, Bertram Glass, Luca Castagna, Silvia Montoto, Ali Bazarbachi
Journal: Blood
Blood (2024) 144 (Supplement 1): 749.
https://doi.org/10.1182/blood-2024-194657
Published: 2024
Journal Articles

Hematopoietic Stem Cell Transplantation for Marginal Zone Lymphoma, a Benchmark Study from the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation

Free
Yasmina I.M. Serroukh, Mathilde Fekom, Irma Khvedelidze, Ben Carpenter, Herve Ghesquieres, Ludovic Gabellier, Jacques-Olivier Bay, Didier Blaise, Maurizio Musso, Patrice Chevallier, Edouard Forcade, Anne Huynh, Andy Peniket, Marek Trněný, Catherine Flynn, Shankara Paneesha, Andrew Clark, Charalampia Kyriakou, Anna Ossami Saidy, Bertram Glass, Luca Castagna, Silvia Montoto, Ali Bazarbachi
Journal: Blood
Blood (2024) 144 (Supplement 1): 3027.
https://doi.org/10.1182/blood-2024-194632
Published: 2024
Journal Articles

IGHV Unmutated Status, Low Tumor Lysis Risk Disease and BRAF Mutated Status Are Predictors for Early MRD Responders Treated with MRD Defined Ibrutinib with Venetoclax: Report of the UK NCRI FLAIR Study

Free
Talha Munir, Abraham Mullasseril Varghese, Adrian Bloor, David Allsup, Kate Cwynarski, Andrew Pettitt, Shankara Paneesha, Christopher P Fox, Toby A. Eyre, Francesco Forconi, Nagah Elmusharaf, Ben Kennedy, Prof. John G. Gribben, Nicholas Pemberton, Oonagh Sheehy, Gavin Preston, Anna Schuh, Anna Hockaday, David A. Cairns, Sharon Jackson, Natasha Greatorex, Sean Girvan, Sue Bell, David Stones, Nichola McWhirter, Surita Dalal, Andrew Rawstron, Piers Patten, Peter Hillmen
Journal: Blood
Blood (2024) 144 (Supplement 1): 585.
https://doi.org/10.1182/blood-2024-211449
Published: 2024
Journal Articles

Ibrutinib as part of risk-stratified treatment for posttransplant lymphoproliferative disorder: the phase 2 TIDaL trial

Free
Clinical Trials & Observations
Sridhar Chaganti, Shanna Maycock, Graham McIlroy, Aimee Jackson, Rebecca Bishop, Sarah Johnson, Edward Kanfer, Shireen Kassam, Kate Cwynarski, David Wrench, Arvind Arumainathan, Christopher P. Fox, Rod Johnson, Pam McKay, Shankara Paneesha, Clare Rowntree, Constantine Balotis, Graham P. Collins, Andrew Davies, Josh Wright, Sarah Burns, Arian Laurence, Keith Wheatley, Tobias Menne
Journal: Blood
Blood (2024) 144 (4): 392–401.
https://doi.org/10.1182/blood.2024023847
Published: 2024
Includes: Supplemental data
Journal Articles

Brexucabtagene Autoleucel for Relapsed/Refractory Mantle Cell Lymphoma: Real-World Outcomes in the United Kingdom

Free
Maeve A O'Reilly, Robin Sanderson, William Wilson, David Burns, Caroline Besley, Thomas Creasey, Ben Uttenthal, Johnathon Elliot, Claire Roddie, Andrea Kuhnl, Shankara Paneesha, Frances Seymour, Sunil Iyengar, Lourdes Rubio, Matthew Wilson, Stephen Boyle, Kathleen PL Cheok, Graham P. Collins, Rod Johnson, Andrew K. McMillan
Journal: Blood
Blood (2022) 140 (Supplement 1): 7519–7521.
https://doi.org/10.1182/blood-2022-165031
Published: 2022
Journal Articles

First-in-Human Phase I Trial of a ROR1 Targeting Bispecific T Cell Engager (NVG-111) in Combination with Ibrutinib or As Monotherapy in Subjects with Relapsed Refractory Chronic Lymphocytic Leukaemia (CLL) and Mantle Cell Lymphoma (MCL)

Free
William Townsend, Sarah Leong, David Tucker, Bryson Pottinger, Shankara Paneesha, Dima El-Sharkawi, Toby A. Eyre, Toby Batten, Mittal Shah, Sarah Cook, David Granger, Kieran O'Donovan, Amit C. Nathwani, Parag Jasani
Journal: Blood
Blood (2022) 140 (Supplement 1): 4162–4163.
https://doi.org/10.1182/blood-2022-169658
Published: 2022
Journal Articles

Combination of Ibrutinib Plus Venetoclax with MRD-Driven Duration of Treatment Results in a Higher Rate of MRD Negativity in IGHV Unmutated Than Mutated CLL: Updated Interim Analysis of FLAIR Study

Free
Talha Munir, Alexandra Pitchford, Adrian Bloor, Andrew Pettitt, Piers E.M. Patten, Francesco Forconi, Anna Schuh, Christopher P Fox, Simona Gatto, Ben Kennedy, John Gribben, Nicholas Pemberton, Oonagh Sheehy, Gavin Preston, Dena Howard, Anna Hockaday, David Cairns, Sharon Jackson, Natasha Greatorex, Nichola McWhirter, Jane Shingles, Kate Cwynarski, Shankara Paneesha, David Allsup, Andrew Rawstron, Peter Hillmen
Journal: Blood
Blood (2022) 140 (Supplement 1): 231–233.
https://doi.org/10.1182/blood-2022-170463
Published: 2022
Journal Articles

Vaccine Efficacy after Rituximab Exposure: First Interim Analysis of Virtue Project on Behalf of West Midlands Research Consortium, UK

Free
Adrian M Shields, Srinivasan Venkatachalam, Shankara Paneesha, Mark Ford, Tom Sheeran, Melanie Kelly, Farheen Karim, Iman Qureshi, Beena Salhan, Neelakshi DeSilva, Jacqueline Stones, Sophie Lee, Jahanzeb Khawaja, Praveen Kumar Kaudlay, Richard Whitmill, Ghulam Nabikakepoto, Sian E Faustini, Alex G Richter, Mark T Drayson, Supratik Basu
Journal: Blood
Blood (2021) 138 (Supplement 1): 196.
https://doi.org/10.1182/blood-2021-150220
Published: 2021
Journal Articles

Sudden or Cardiac Deaths on Ibrutinib-Based Therapy Were Associated with a Prior History of Hypertension or Cardiac Disease and the Use of ACE-Inhibitors at Study Entry: Analysis from the Phase III NCRI FLAIR Trial

Free
Talha Munir, Alexandra Pitchford, Adrian Bloor, Angus Broom, Moya Young, Ben Kennedy, Renata Walewska, Michelle Furtado, Gavin Preston, Jeffrey R. Neilson, Nicholas Pemberton, Gamal Sidra, Nicholas Morley, Kate Cwynarski, Anna Schuh, Francesco Forconi, Simona Gatto, Shankara Paneesha, Christopher P. Fox, Dena Howard, Anna Hockaday, David Cairns, Sharon Jackson, Natasha Greatorex, Piers EM Patten, David Allsup, Peter Hillmen
Journal: Blood
Blood (2021) 138 (Supplement 1): 2636.
https://doi.org/10.1182/blood-2021-152167
Published: 2021
Journal Articles

Risk-Stratified Sequential Treatment with Ibrutinib and Rituximab (IR) and IR-CHOP for De-Novo Post-Transplant Lymphoproliferative Disorder: Results of the Tidal Trial

Free
Sridhar Chaganti, Shanna Maycock, Graham McIlroy, Waleed A Iqbal, John Mason, Edward Kanfer, Shireen Kassam, Kate Cwynarski, David Wrench, Arvind K. Arumainathan, Christopher P Fox, Rod Johnson, Pam McKay, Shankara Paneesha, Clare J Rowntree, Constantine-George Balotis, Graham P. Collins, Andrew Davies, Josh Wright, Keith Wheatley, Tobias F Menne
Journal: Blood
Blood (2021) 138 (Supplement 1): 2492.
https://doi.org/10.1182/blood-2021-146494
Published: 2021
Journal Articles

COVID-19 Infection of HSCT Recipients Is Associated with High Mortality but No Detectable Cytokine Storm at Presentation

Free
Giovanna Lucchini, Elena Cozma, Aimee Jackson, Kimberly Gilmour, Rachel Elizabeth Protheroe, Eleni Tholouli, Robert F Wynn, Keith Wilson, Karl S Peggs, Victoria Potter, Anne Parker, Charles Craddock, Shankara Paneesha, Emma Nicholson, David I. Marks, Oana Mirci-Danicar, Christopher Parrish, Alexander M Martin, Graham McIlroy, Rebecca Bishop, Rebecca Collings, Ellie Williams, Persis J Amrolia
Journal: Blood
Blood (2021) 138 (Supplement 1): 1788.
https://doi.org/10.1182/blood-2021-146515
Published: 2021
Journal Articles

CPX-351 for Acute Myeloid Leukaemia: Real World Results Are Comparable to Trial Outcomes and Exceeds Them in Non-Adverse Risk Patients- a Multicentre Experience from West Midlands Hospitals on Behalf of West Midlands Research Consortium ( WMRC) UK

Free
Vidhya Murthy, Richard Whitmill, Clare Lodwick, Peter Dyer, Maria Ahmed, Rehmatullah Khan, Shankara Paneesha, Nicholas Pemberton, Manoj Raghavan
Journal: Blood
Blood (2021) 138 (Supplement 1): 4416.
https://doi.org/10.1182/blood-2021-150199
Published: 2021