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Journal Articles

Bexobrutideg (NX-5948), a novel Bruton's tyrosine kinase (BTK) degrader, shows high clinical activity and tolerable safety in patients with Waldenström macroglobulinemia: Updated results from an ongoing Phase 1a/b study

Free
Nirav Shah, Scott Huntington, David Lewis, Talha Munir, Graham Collins, Alvaro Alencar, Kim Linton, Zulfa Omer, Dima El-Sharkawi, Mary Gleeson, Pamela McKay, Jeanette Doorduijn, Jeffery Smith, Daniel Morillo, Pau Abrisqueta, Sarah Injac, Astrid Pulles
Journal: Blood
Blood (2025) 146 (Supplement 1): 5359.
https://doi.org/10.1182/blood-2025-5359
Published: 2025
Journal Articles

Updates of R/R CLL with prior exposure to Bruton's tyrosine kinase (BTK) inhibitor and/or bcl-2 inhibitor in the Phase 1 trial of LP-168 (Rocbrutinib), a novel COVALENT and non-COVALENT BTK inhibitor

Free
Jennifer Woyach, Danielle Brander, Boyu Hu, Kerry Rogers, Zulfa Omer, Emily Curran, Deborah Stephens, Andrea Sitlinger, Yi Chen, Stephen Anthony, Yu Chen, Kewei Shang, John Byrd
Journal: Blood
Blood (2025) 146 (Supplement 1): 87.
https://doi.org/10.1182/blood-2025-87
Published: 2025
Journal Articles

Bexobrutideg (NX-5948), a novel Bruton's tyrosine kinase (BTK) degrader, demonstrates rapid and durable clinical responses in Relapsed/Refractory chronic lymphocytic leukemia (CLL): New and updated findings from an ongoing Phase 1a/b trial

Free
Zulfa Omer, Alexey Danilov, Francesco Forconi, Talha Munir, Mary Gleeson, Nirav Shah, Graham Collins, Alvaro Alencar, Jane Robertson, Jonathon Cohen, Karan Dixit, Danielle Brander, John Byrd, Allison Winter, Jeffery Smith, Dima El-Sharkawi, Michal Kwiatek, Iwona Hus, Prioty Islam, Sebastian Grosicki, Michael Tees, Thorsten Zenz, Joanna Romejko-Jarosinska, Sarah Injac, Wojciech Jurczak
Journal: Blood
Blood (2025) 146 (Supplement 1): 86.
https://doi.org/10.1182/blood-2025-86
Published: 2025
Journal Articles

The use and safety of peripheral intravenous catheters (PIV) vs central venous catheters (CVC) for lymphoma patients receiving frontline anthracycline-based chemotherapy: A large multicenter real-world analysis (RWA)

Free
Yun Kyoung Tiger, Patrick Glennan, Adrienne Nedved, Joseph Lukowski, Abdus-Samad Minhaj, Alexander Sanjurjo, Melinda Harbhajan, Jacqueline Norrell, Salmaan Mubeen, Frederique St-Pierre, Gabriel Kindl, Keem Patel, Olutobi Adewale, Harris Allen, Sophia Luyten, Srilatha Dasari, Zulfa Omer, Peter Martin, Seda Tolu, Carla Casulo, Matthew Lunning, Grzegorz Nowakowski, Andrew Evens
Journal: Blood
Blood (2025) 146 (Supplement 1): 518.
https://doi.org/10.1182/blood-2025-518
Published: 2025
Journal Articles

Clinical and molecular characteristics of Philadelphia chromosome positive B-cell precursor acute lymphoblastic leukemia with central nervous system relapse versus systemic relapse: Results from consortium on myeloid malignancies and neoplastic diseases (COMMAND)

Free
Rafael Madero-Marroquin, Ravi Kishore Narra, Alice Mims, Alexander Coltoff, Georgio Medawar, Brooke Hisrich, Rory Shallis, Cameron Hunter, Vamsi Kota, Tamer Othman, Brian Jonas, Shreya Desai, Guilherme Sacchi De Camargo Correia, Adam Duvall, Neil Palmisiano, Emily Curran, Zulfa Omer, Anjali Advani, Ehab Atallah, Mark Litzow, Anand Patel, Talha Badar
Journal: Blood
Blood (2025) 146 (Supplement 1): 3320.
https://doi.org/10.1182/blood-2025-3320
Published: 2025
Journal Articles

The Incidence of CNS Relapse in Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia (ALL) and Its Impact on Clinical Outcome: Results from Consortium on Myeloid Malignancies and Neoplastic Diseases (COMMAND)

Free
Kashish J. Shah, Mobachir El Kettani, Ravi Narra, Alice Mims, Alexander Coltoff, Georgio Medawar, Brooke Hisrich, Rory M. Shallis, Cameron J. Hunter, Vamsi K. Kota, Tamer Othman, Brian A. Jonas, Shreya Desai, Guilherme Sacchi de Camargo Correia, Anand Ashwin Patel, Adam S. Duvall, Neil D. Palmisiano, Emily K Curran, Zulfa Omer, Anjali S. Advani, Ehab L. Atallah, Mark R. Litzow, Talha Badar
Journal: Blood
Blood (2024) 144 (Supplement 1): 4184.
https://doi.org/10.1182/blood-2024-205812
Published: 2024
Journal Articles

LP-168 (Rocbrutinib), a Novel Covalent and Non-Covalent Next-Generation Inhibitor of Bruton's Tyrosine Kinase: Updates on the Phase 1 Trial and Initial Results of the CLL Gatekeeper Mutation Cohort

Free
Jennifer A. Woyach, Danielle M. Brander, Boyu Hu, Kerry A. Rogers, Zulfa Omer, Deborah M. Stephens, Andrea Sitlinger, Fenlai Tan, Yi Chen, Stephen P. Anthony, Yu Chen, Kewei Shang, John C. Byrd
Journal: Blood
Blood (2024) 144 (Supplement 1): 4622.
https://doi.org/10.1182/blood-2024-205775
Published: 2024
Journal Articles

Efficacy and Safety of the Bruton's Tyrosine Kinase (BTK) Degrader NX-5948 in Patients with Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL): Updated Results from an Ongoing Phase 1a/b Study

Free
Nirav N. Shah, Zulfa Omer, Graham P. Collins, Francesco Forconi, Alexey Danilov, John C. Byrd, Dima El-Sharkawi, Emma Searle, Alvaro J Alencar, Shuo Ma, Sarah Injac, Talha Munir
Journal: Blood
Blood (2024) 144 (Supplement 1): 884.
https://doi.org/10.1182/blood-2024-194839
Published: 2024
Journal Articles

Clinical Characteristics and Outcome in a Cohort of CLL Patients with BTK T474 Gatekeeper Mutation

Free
Zulfa Omer, Max Yano, Jayesh Rai, Joyce Chen, Jennifer A. Woyach, Seema A. Bhat, Michael R. Grever, Dan Jones, Kerry A. Rogers, John C. Byrd
Journal: Blood
Blood (2024) 144 (Supplement 1): 1875.
https://doi.org/10.1182/blood-2024-209336
Published: 2024
Journal Articles

A Multi-Center Retrospective Study on Complex Karyotype in Patients with Richter Transformation Who Received No Chemoimmunotherapy for Their CLL

Free
Cecelia Miller, Ying Huang, John N. Allan, Seema A. Bhat, David A. Bond, Danielle M. Brander, John C. Byrd, Julio C. Chavez, Elise A. Chong, Alexey Danilov, Mark R Dowling, Kaitlyn M. Dvorak-Kornaus, Paul J. Hampel, Carrie I Ho, Prioty Islam, Nikita Malakhov, Matthew Matasar, Sarah Miller, Sameer A. Parikh, Kari G. Rabe, Joanna M. Rhodes, Lindsey Roeker, Kerry A. Rogers, Aditi Saha, Alan P Skarbnik, Hamish W Scott, Jake Schade, Mazyar Shadman, Geoffrey Shouse, Deborah M. Stephens, Meghan C. Thompson, Philip A. Thompson, Yucai Wang, Jennifer A. Woyach, Max Yano, Zulfa Omer, Adam S Kittai
Journal: Blood
Blood (2024) 144 (Supplement 1): 3245.
https://doi.org/10.1182/blood-2024-205668
Published: 2024