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David Cairns
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Journal Articles

Is IMWG frailty-score-adjusted dosing the right approach to improve toxicity and outcomes in FRAIL patients? Results from the UK-MRA FiTNEss trial in newly diagnosed myeloma patients ineligible for ASCT.

Free
Charlotte Pawlyn, Kara-Louise Royle, Ethan Senior, Dax Everritt, Jenny Bird, Stella Bowcock, Bryony Dawkins, Mark Drayson, Sharon Gillson, Catherine Olivier, Matthew Jenner, John Jones, Martin Kaiser, Bhuvan Kishore, David Meads, Neil Rabin, Roger Owen, Ruth de Tute, Christopher Parrish, Alan Chant, David Cairns, Graham Jackson, Gordon Cook
Journal: Blood
Blood (2025) 146 (Supplement 1): 369.
https://doi.org/10.1182/blood-2025-369
Published: 2025
Journal Articles

Ibrutinib plus rituximab leads to superior progression-free and overall survival to FCR in previously untreated CLL: Results of the Phase III NCRI FLAIR trial

Free
Talha Munir, Sean Girvan, Annah Muli, David Cairns, David Allsup, Adrian Bloor, Abraham Mullasseril Varghese, Angus Broom, Moya Young, Ben Kennedy, Renata Walewska, Michelle Furtado, Gavin Preston, Jeffrey Neilson, Nicholas Pemberton, Gamal Sidra, Nick Morley, Kate Cwynarski, Toby Eyre, Francesco Forconi, Simona Gatto, Shankara Paneesha, Christopher Fox, Dena Howard, Anna Hockaday, Julia Brown, Sharon Jackson, David Stones, Sue Bell, Natasha Greatorex, Nichola Webster, Jane Shingles, Surita Dalal, Piers Patten, Andy Rawstron, Peter Hillmen
Journal: Blood
Blood (2025) 146 (Supplement 1): 2128.
https://doi.org/10.1182/blood-2025-2128
Published: 2025
Journal Articles

MRD-guided ibrutinib plus venetoclax improves outcomes in CLL patients with TP53, ATM, or NOTCH1 aberrations compared to ibrutinib and FCR: Results from the Phase III NCRI FLAIR trial

Free
Surita Dalal, Jane Shingles, Sean Girvan, David Cairns, Paul Glover, Helen Warren, Thomas Grand, Nichola Webster, Andy Rawstron, Darren Newton, Charlotte Evans, Ruth de Tute, Anna Hockaday, Sharon Jackson, Sue Bell, Natasha Greatorex, David Stones, David Allsup, Adrian Bloor, Anita Sarma, Abraham Mullasseril Varghese, Peter Hillmen, Talha Munir
Journal: Blood
Blood (2025) 146 (Supplement 1): 679.
https://doi.org/10.1182/blood-2025-679
Published: 2025
Journal Articles

Double hit ultra-high risk myeloma treated with isatuximab, bortezomib, lenalidomide, dexamethasone and cyclophosphamide (Isa-VRDc) induction and isa-VRD consolidation: Initial results of the UK myeloma research alliance (UKMRA)  RADAR trial in newly diagnosed transplant eligible patients

Free
Karthik Ramasamy, Kara-Louise Royle, Robert Cicero, Ruth de Tute, Matthew Jenner, Ceri Bygrave, Rakesh Popat, Dipal Mehta, Laura Chiecchio, Berrin Balik, Mohammad Kazeroun, Guy Pratt, Catherine Olivier, Lorna Barnard, Sharon Jackson, Charlotte Kennaway, Gordon Cook, Alan Chant, David Meads, Bryony Dawkins, Michael Chapman, Graham Jackson, Andrew Chantry, Martin Kaiser, Jonathan Sive, Sarah Gooding, Eileen Boyle, Christopher Parrish, Dean Smith, Y L Tracey Chan, Roger Owen, David Cairns, Kwee Yong
Journal: Blood
Blood (2025) 146 (Supplement 1): 98.
https://doi.org/10.1182/blood-2025-98
Published: 2025
Journal Articles

Optimising MRD-guided treatment: UMRD4 as a half-way treatment timepoint for ibrutinib-venetoclax substantially delays MRD relapse after end of treatment in both IGHV-mutated and IGHV-unmutated CLL.

Free
Andy Rawstron, David Cairns, Nichola Webster, Surita Dalal, Jane Shingles, Ruth de Tute, Anna Hockaday, Sharon Jackson, Sue Bell, Natasha Greatorex, David Stones, David Allsup, Adrian Bloor, Anita Sarma, Abraham Mullasseril Varghese, Talha Munir, Peter Hillmen
Journal: Blood
Blood (2025) 146 (Supplement 1): 794.
https://doi.org/10.1182/blood-2025-794
Published: 2025
Journal Articles

Applying computational modelling to a high-risk multiple myeloma data set to create novel risk stratification groupings

Free
Orthi Shahzad, Richard Norris, Niels Weinhold, Charlotte Pawlyn, Brian Walker, Cody Ashby, Christopher Wardell, David Cairns, Martin Kaiser, Gordon Cook, Faith Davies, Mark Drayson, Roger Owen, Graham Jackson, Gareth Morgan, Simon Mitchell, John Jones
Journal: Blood
Blood (2025) 146 (Supplement 1): 5790.
https://doi.org/10.1182/blood-2025-5790
Published: 2025
Journal Articles

Combination of Ibrutinib Plus Venetoclax with MRD-Driven Duration of Treatment Results in a Higher Rate of MRD Negativity in IGHV Unmutated Than Mutated CLL: Updated Interim Analysis of FLAIR Study

Free
Talha Munir, Alexandra Pitchford, Adrian Bloor, Andrew Pettitt, Piers E.M. Patten, Francesco Forconi, Anna Schuh, Christopher P Fox, Simona Gatto, Ben Kennedy, John Gribben, Nicholas Pemberton, Oonagh Sheehy, Gavin Preston, Dena Howard, Anna Hockaday, David Cairns, Sharon Jackson, Natasha Greatorex, Nichola McWhirter, Jane Shingles, Kate Cwynarski, Shankara Paneesha, David Allsup, Andrew Rawstron, Peter Hillmen
Journal: Blood
Blood (2022) 140 (Supplement 1): 231–233.
https://doi.org/10.1182/blood-2022-170463
Published: 2022
Journal Articles

The Impact of Lymphocyte Composition in the Stem Cell Harvest on Blood Lymphocytes 1-2 Weeks Post-Autologous Stem Cell Transplant for Newly Diagnosed Myeloma

Free
Benjamin Dimbleby, Tatiana Zhelezniakova, Alex G Richter, Charlotte Pawlyn, John R Jones, Matthew W Jenner, David Cairns, Tom Menzies, Walter Martin Gregory, Martin F. Kaiser, Gordon Cook, Roger G Owen, Graham Jackson, Faith E Davies, Gareth J. Morgan, Mark T Drayson
Journal: Blood
Blood (2022) 140 (Supplement 1): 4299–4300.
https://doi.org/10.1182/blood-2022-169774
Published: 2022
Journal Articles

Second Primary Malignancy Incidence in Patients Receiving Lenalidomide at Induction and Maintenance; Long-Term Follow up of 4358 Patients Enrolled to the Myeloma XI Trial

Free
John R Jones, David Cairns, Tom Menzies, Charlotte Pawlyn, Faith E. Davies, Rachel Sigsworth, Matthew W Jenner, Martin F. Kaiser, Rebecca Mottram, Mark T Drayson, Walter Martin Gregory, Roger G Owen, Kevin Boyd, Gordon Cook, Graham Jackson, Gareth J. Morgan
Journal: Blood
Blood (2022) 140 (Supplement 1): 1823–1825.
https://doi.org/10.1182/blood-2022-168723
Published: 2022
Journal Articles

Risk-Adapted Therapy Directed According to Response (RADAR, UK-MRA Myeloma XV) - Comparing MRD-Guided Treatment Escalation and De-Escalation Strategies in Patients with Newly Diagnosed Myeloma Suitable for Stem Cell Transplantation

Free
Kwee Yong, Kara-Louise Royle, Karthik Ramasamy, Christopher Parrish, Anna Hockaday, Samir Asher, Mark T Drayson, Ruth M. de Tute, Matthew W Jenner, Martin F. Kaiser, Guy Pratt, Jonathan Sive, Ceri Bygrave, Gordon Cook, Rakesh Popat, Dean Smith, Catherine Olivier, Lorna Barnard, Doina Levinte, Bryony Dawkins, Michael A Chapman, Andrew D Chantry, Graham Jackson, Sergio A Quezada, Roger G Owen, David Cairns
Journal: Blood
Blood (2022) 140 (Supplement 1): 1844–1846.
https://doi.org/10.1182/blood-2022-168842
Published: 2022
Journal Articles

The Impact of Autologous Stem Cell Transplantation on the Genetics of High-Risk Relapsed Multiple Myeloma

Free
Mohamed Shahin, Charlotte Pawlyn, Niels Weinhold, Timothy Cody Ashby, Brian A. Walker, Christopher P. Wardell, David Cairns, Tom Menzies, Walter Martin Gregory, Martin F. Kaiser, Gordon Cook, Mark T Drayson, Roger G Owen, Graham Jackson, Faith E Davies, Gareth J. Morgan, John R Jones
Journal: Blood
Blood (2022) 140 (Supplement 1): 4232–4233.
https://doi.org/10.1182/blood-2022-169628
Published: 2022
Journal Articles

Defining the Optimal Duration of Lenalidomide Maintenance after Autologous Stem Cell Transplant - Data from the Myeloma XI Trial

Free
Charlotte Pawlyn, Tom Menzies, Faith E Davies, Ruth M. de Tute, Rowena Henderson, Gordon Cook, Matthew W Jenner, John R Jones, Martin F. Kaiser, Mark T Drayson, Roger G Owen, David Cairns, Gareth J. Morgan, Graham Jackson
Journal: Blood
Blood (2022) 140 (Supplement 1): 1371–1372.
https://doi.org/10.1182/blood-2022-165376
Published: 2022
Journal Articles

Co-Occurrence of High-Risk Lesions Is a Consistent Predictor of Ultra-High Risk Multiple Myeloma in Newly Diagnosed and Relapsed/Refractory Patients - Meta-Analysis of 5,808 Trial Patients

Free
Martin F. Kaiser, Pieter Sonneveld, David Cairns, Marc S Raab, Alessandra Larocca, Sarah R Brown, Marc-A. Baertsch, Cong Li, Pellegrino Musto, Kwee Yong, Elias K Mai, Andrea Capra, Gordon Cook, Hartmut Goldschmidt, Mario Boccadoro, Graham Jackson, Niels Weinhold, Francesca Gay
Journal: Blood
Blood (2022) 140 (Supplement 1): 1556–1558.
https://doi.org/10.1182/blood-2022-160130
Published: 2022
Journal Articles

Fitness, a UK Myeloma Research Alliance (UK-MRA) Frailty-Adjusted Therapy Study, Supports the Feasibility of Recruiting Frail Newly Diagnosed Myeloma Patients to Large Clinical Trials

Free
Gordon Cook, Charlotte Pawlyn, Kara-Louise Royle, Amy Beth Coulson, Jennifer Bird, Stella Bowcock, Matthew W Jenner, Bhuvan Kishore, Christopher Parrish, Neil K Rabin, Phillip Best, Sharon Gillson, Rowena Henderson, Catherine Olivier, Martin F. Kaiser, Ruth M. de Tute, Roger G Owen, Mark T Drayson, John R Jones, Bryony Dawkins, David Meads, David Cairns, Graham Jackson
Journal: Blood
Blood (2021) 138 (Supplement 1): 81.
https://doi.org/10.1182/blood-2021-146650
Published: 2021
Journal Articles

Sudden or Cardiac Deaths on Ibrutinib-Based Therapy Were Associated with a Prior History of Hypertension or Cardiac Disease and the Use of ACE-Inhibitors at Study Entry: Analysis from the Phase III NCRI FLAIR Trial

Free
Talha Munir, Alexandra Pitchford, Adrian Bloor, Angus Broom, Moya Young, Ben Kennedy, Renata Walewska, Michelle Furtado, Gavin Preston, Jeffrey R. Neilson, Nicholas Pemberton, Gamal Sidra, Nicholas Morley, Kate Cwynarski, Anna Schuh, Francesco Forconi, Simona Gatto, Shankara Paneesha, Christopher P. Fox, Dena Howard, Anna Hockaday, David Cairns, Sharon Jackson, Natasha Greatorex, Piers EM Patten, David Allsup, Peter Hillmen
Journal: Blood
Blood (2021) 138 (Supplement 1): 2636.
https://doi.org/10.1182/blood-2021-152167
Published: 2021
Journal Articles

The Impact of gain1q on Mutational Structure and Clonal Evolution in a Uniformly Treated High-Risk Series of Patients at First Relapse

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John R Jones, Charlotte Pawlyn, Niels Weinhold, Timothy Cody Ashby, Brian A Walker, Christopher P. Wardell, David Cairns, Walter Martin Gregory, Martin F. Kaiser, Gordon Cook, Mark T Drayson, Roger G Owen, Graham Jackson, Faith E Davies, Gareth J. Morgan
Journal: Blood
Blood (2021) 138 (Supplement 1): 2683.
https://doi.org/10.1182/blood-2021-152123
Published: 2021
Journal Articles

Phenotypic High-Risk Disease in the Context of Carfilzomib and Lenalidomide Combination Induction Therapy for Newly Diagnosed Transplant-Eligible Myeloma Patients

Free
Charlotte Pawlyn, Faith E Davies, Tom Menzies, Rowena Henderson, Gordon Cook, Matthew W Jenner, John R Jones, Martin F. Kaiser, Roger G Owen, Mark T Drayson, David Cairns, Gareth J. Morgan, Graham Jackson
Journal: Blood
Blood (2021) 138 (Supplement 1): 2907.
https://doi.org/10.1182/blood-2021-151102
Published: 2021
Journal Articles

Enrolment and Outcomes of Ethnic Minorities with Multiple Myeloma Treated in UK Myeloma Research Alliance (UK-MRA) Clinical Trials over 18 Years

Free
Rakesh Popat, Zoe Craig, Faith E Davies, David Cairns, Catherine Olivier, J Anthony Child, Gareth J. Morgan, Gordon Cook, Graham H Jackson
Journal: Blood
Blood (2021) 138 (Supplement 1): 4118.
https://doi.org/10.1182/blood-2021-149148
Published: 2021
Journal Articles

Residual Monoclonal Free Light Chain Positivity By Mass Spectrometry Identifies Patients at Increased Risk of Early Relapse Following First-Line Anti-Myeloma Treatment

Free
Hannah Victoria Giles, Mark T Drayson, Nicola Wright, Gordon Cook, Faith E. Davies, Gareth J Morgan, Ruth M. de Tute, Roger G Owen, David Cairns, Anna Hockaday, Tom Menzies, Martin F. Kaiser, Charlotte Pawlyn, Graham Jackson, Guy Pratt
Journal: Blood
Blood (2021) 138 (Supplement 1): 820.
https://doi.org/10.1182/blood-2021-150479
Published: 2021
Journal Articles

Multistate Models Demonstrate That Lenalidomide Maintenance Enhances Survival By Prolonging Time in First Remission for Patients Treated in the UK NCRI Myeloma XI Randomised Trial

Free
Zoe Craig, Christopher Parrish, Charlotte Pawlyn, Martin F. Kaiser, Catherine Olivier, John R Jones, Mark T Drayson, Roger G Owen, Matthew W Jenner, Gordon Cook, Walter Martin Gregory, Faith E Davies, Gareth J. Morgan, Graham Jackson, David Cairns
Journal: Blood
Blood (2021) 138 (Supplement 1): 3758.
https://doi.org/10.1182/blood-2021-150631
Published: 2021