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Research Article October 1 2025

The single-cell atlas of bone marrow B cells reveals defective central B-cell tolerance in immune thrombocytopenia

Zi Sheng,Nan Jiang,Yan Gao,Yuhan Zhang,Xiaoyu Zhang,Nailin Li,Qi Feng,Yanqi Zhang,Limei Wang,John W. Semple,Shuwen Wang,Song Li,Jun Peng

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Research Article October 1 2025

Mucosal calprotectin is associated with severity of aGI-GVHD and poor outcomes after allogeneic stem cell transplantation

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Research Article October 1 2025

Domain and Residue Mapping of Autoantibodies to β2GPI Reveals Differences Among Antiphospholipid Syndrome Phenotypes

Suresh Kumar,Deepesh Vaid,Paola Adele Lonati,Arianna Da Via,Marta Tonello,Pier Luigi Luigi Meroni,Vittorio Pengo,Nicola Pozzi

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Research Article October 1 2025

Fetal context conveys heritable protection against MLL-rearranged AML that depends on MLL3

Jonny Mendoza-Castrejon,Wei Yang,Elisabeth D Denby,Helen C. Wang,Emily B. Casey,Rohini Muthukumar,Riddhi M. Patel,Jihye Yoon,Yanan Li,J. Michael White,Ran Chen,Luis Francisco Zirnberger Batista,Jeffrey A Magee

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Review Article September 30 2025

The Biology of MZL subtypes: Challenge and Relevance of Classification

Camille Laurent,Francesco Bertoni

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Brief Report September 30 2025

Genome-wide analysis defines genetic determinants of MPN subtypes and identifies a sex-specific association at CDH22/CD40

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Research Article September 30 2025

Mechanisms of immune escape and extramedullary tropism in leukemia cutis

Livius Penter,Katie Maurer,Nicoletta Cieri,Wesley Lu,Haoxiang Lyu,Mischa Selig,Maria Joosten,Jana Ihlow,Shuqiang Li,Kenneth J Livak,Lars Bullinger,Jerome Ritz,Pavan Bachireddy,Matthew S. Davids,Jacqueline S. Garcia,Robert J. Soiffer,Catherine J Wu

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Research Article September 25 2025

USP25-Mediated Talin-1 Stabilization in Platelets: A Novel Mechanism of Hyperreactivity and Thrombosis Risk During Aging

Xuemei Jia,Shuoyi Jiang,Hong Cheng,zhicheng wang,Zhihan Chen,weiguo Dong,Haoxuan Zhong,Qi Zhang,Xianmin Song,Si Zhang,Rong Xia

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Research Article September 25 2025

Interplay of procoagulatory and neutrophil-derived anticoagulatory proteins in C1q-NET-driven blood coagulation

Minnah Thomas,Davor Frleta,KehDih Lai,John O'Brien,Aditi Khatri Patel,Yuanqi Zhao,Keith Adam Kobylarz,Naxin Tu,Gabor Halasz,Chunguang Guo,Lynn Macdonald,Lori Morton,Dan Chalothorn,Kishor B Devalaraja-Narashimha

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Research Article September 25 2025

PROs vs clinician-reported adverse events in a large clinical trial: findings from the phase 3 POLARIX study

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Research Article September 25 2025

Genomic landscape of IgM-MGUS and patients with stable or progressive asymptomatic Waldenström macroglobulinemia

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Research Article September 24 2025

CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias

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Research Article September 24 2025

High-risk genomic consensus validation for patients with newly diagnosed multiple myeloma using next-generation sequencing

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Research Article September 24 2025

Fusion Gene Depletion Eliminates Stemness and Induces Bidirectional Differentiation of Acute Myeloid Leukemia

Polina K Derevyanko,Laura E Swart,L. Daniel Mata Casimiro,Anita van Oort,Manisha Du Plessis,Luca van den Brink,Minoo Ashtiani,C. Michel Zwaan,Anja Krippner-Heidenreich,Constanze Bonifer,Ray Michel Schiffelers,Josef Josef Vormoor,Sophie Kellaway,Olaf Heidenreich

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Research Article September 24 2025

Prognostic value of premaintenance FDG PET/CT response in patients with newly diagnosed myeloma from the CASSIOPEIA trial

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Research Article September 22 2025

Target antigen and plasma cell phenotype are critical factors for sensitivity to response-adapted daratumumab therapy

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Research Article September 22 2025

INCREASED LEF1 PROTEIN LEVELS AND ISOFORM SWITCHING DRIVE CELL PROLIFERATION IN CHRONIC LYMPHOCYTIC LEUKEMIA

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Research Article September 22 2025

Alternative AAV gene therapy for hemophilia A using expression of Bi8, a novel single-chain FVIII-mimetic antibody

Vincent Muczynski,Olivier D. Christophe,Lewis Tanner,Charlotte Vayssiere,Alice Guérin,Caterina Casari,Jenny Hazel McIntosh,Doyoung Lee,Gavin Ling,Satyen Harish Gohil,Peter J Lenting,Edward G Tuddenham,Amit C Nathwani

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Review Article September 22 2025

Clonal tracing of blood stem cells across mouse and human lifespans

Alejo E Rodriguez-Fraticelli

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Research Article September 22 2025

Determining telomere content and genomics of myeloid neoplasia by whole-genome sequencing

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Research Article September 22 2025

Talquetamab plus daratumumab for the treatment of relapsed or refractory multiple myeloma in the TRIMM-2 study

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Brief Report September 22 2025

Tissue transglutaminase drives fibrin β-chain cross-linking: a novel fibrin modification observed in trauma patients

Nana Kwame Kwabi Boateng,Riley Marie Wimberley,Jacob P Rose,Angelo D'Alessandro,Mitchell J Cohen,Ernest E Moore,Lauren Schmitt,Lauren Poole,James P. Luyendyk,Kirk C Hansen

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Research Article September 22 2025

Hematopoietic stem cell transplantation for purine nucleoside phosphorylase deficiency: an EBMT-IEWP retrospective study

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Research Article September 19 2025

Reprogramming glutamine metabolism enhances BCMA-CART cell fitness and therapeutic efficacy in multiple myeloma

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Research Article September 19 2025

VEXAS anemia is a mosaic erythroblastopenia

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Letter September 19 2025

FLAG-IDA plus venetoclax for children, adolescents, and young adults with newly diagnosed AML

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Research Article September 19 2025

The watch-and-wait approach for patients with juvenile myelomonocytic leukemia: results of the French cohort

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Review Article September 17 2025

Drug development in MZL: caring for the forgotten child

Catherine Thieblemont,Sylvain Carras,Côme Bommier

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Research Article September 17 2025

Rbm38 Deficiency Impairs Erythroid Heme Biosynthesis and Induces Porphyria via Reduced Ferrochelatase Expression

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Research Article September 17 2025

A genome-wide screen identifies Runx2 as a novel regulator of hematopoietic stem cell expansion and T-cell commitment

Grace A Meaker,Matthew Nicholls,Catherine Chahrour,Ian Hsu,Alastair Smith,Yavor Bozhilov,Maurice Ga Hay Leung,Hugo Vassort, Mr,Leonid Olender,Oliver Beaven,Xinran Huang,Elizabeth J Brown,Marlies Vanden Bempt,Hwei Minn Khoo,Joydeep Bhadury,Thomas A Milne,Adam C. Wilkinson

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Research Article September 17 2025

Sclerotic GVHD and Scleroderma Share Dysregulated Gene Expression that is Ameliorated by EREG Therapeutic Antibody

Nathan M Newton,Kriti Agrawal,Anahi V Odell,Timothy Scott Tracy,Craig Stanway Hackett,Anne B. Eldrup,Michael Whitfield,Viktor Martyanov,Michael Girardi,Esen Sefik,Richard A. Flavell,Ian D Odell

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Letter September 12 2025

Human herpesvirus 6 viremia and encephalitis in CAR T-cell recipients

Stephanie Teresa Isaac,David C Bishop,Fahad Shaikh,Kenneth P Micklethwaite,David J Gottlieb,Emily Blyth

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Brief Report September 12 2025

Impact of immunochemotherapy regimens on outcomes of patients with primary mediastinal B-cell lymphoma in the IELSG37 trial

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Research Article September 12 2025

Targeting STK17B kinase activates ferroptosis and suppresses drug resistance in multiple myeloma

Zhibo Yan,Zhannan Han,Yihui Wang,Maja Beus,Yu Zhang,Alfredo Picado,Carrow I. Wells,Jian Wu,Loren B. Weidenhammer,Karla M. Pires,Elizabeth A. Leibold,Liang Liu,David M. Gooden,Ivan Spasojevic,Erik Soderblom,Yubin Kang,Lawrence H Boise,Timothy M. Willson,Mikhail A. Nikiforov

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Research Article September 9 2025

Isatuximab for Relapsed and/or Refractory AL Amyloidosis: Results of a Prospective Phase 2 Trial (SWOG S1702)

Terri Parker,Adam Landon Rosenthal,Vaishali Sanchorawala,Heather J Landau,Erica L. Campagnaro,Prashant Kapoor,Natalia Neparidze,Saulius K. Girnius,Patrick Hagen,Emma C Scott,Antje Hoering,Brian G.M. Durie,Robert Z Orlowski

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Brief Report September 9 2025

Intestinal hepcidin overexpression promotes iron deficiency anemia and counteracts iron overload via DMT1 downregulation

Marion Falabrègue,Candice Aurrand,Léa Cazaulon,Nadia Boussetta,Sara Zumerle,Zoubida Karim,Nouzha Djebrani-Oussedik,Joel POUPON,Sandra Guilmeau,Emeric Dupe,Anne Aucouturier,Philippe Langella,Luis G Bermudez-Humaran,Sophie Vaulont,Carole Peyssonnaux

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Research Article September 8 2025

Nuclear respiratory factor 1 promotes cell survival in multiple myeloma under proteasome inhibition therapy

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Research Article September 8 2025

Fixed-Duration Epcoritamab Plus R2 Drives Favorable Outcomes in Relapsed or Refractory Follicular Lymphoma

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Research Article September 8 2025

CUX1 restrains latent hematopoietic stem cell plasticity by suppressing stem cell-intrinsic inflammatory pathways

Tanner C Martinez,Matthew R. M. Jotte,Saira Khan,Angela Stoddart,Hunter Z. Blaylock,Ankit Malik,Megan E. McNerney

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Research Article September 8 2025

Platelet Factor 4 (PF4) Regulates Hematopoietic Stem Cell Aging

Sen Zhang,Charles E. Ayemoba,Anna M. Di Staulo,Kenneth Joves,Chandani M. Patel,Eva Hin Wa Leung,Maura Lima Pereira Bueno,Xiaoping Du,Mortimer Poncz,Sang-Ging Ong,Claus Nerlov,Maria Maryanovich,Constantinos Chronis,Sandra Pinho

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Research Article September 4 2025

Leukemia escapes immunity by imposing a type 1 regulatory program on neoantigen-specific CD4+ T cells

Hrishi Venkatesh,Enoc Granados Centeno,Qianyun Luo,Miriam Arroyo,Lynn M Heltemes Harris,Todd Philip Knutson,Yinjie Qiu,Allison Haaning,Beau R Webber,Veronika Bachanova,Michael A Farrar,Sean I Tracy

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Research Article September 4 2025

Innate lymphoid cells prevent graft-versus-host disease via IL-9-driven T-cell senescence

Dejene Milkessa Tufa,Eric Hoffmeyer,Kristin L Schaller,Ben Kooiman,Elena Woods,Dong Wang,Dallas Clinton Jones,Spencer C Hall,Joselyn Cruz Cruz,Michael Vernaris

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Research Article September 4 2025

Acalabrutinib treatment for older (≥80 years old) and/or frail patients with CLL: primary end point analysis of the CLL-Frail trial

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Review Article September 4 2025

Platelet heterogeneity in disease: the many and the diverse?

Rainer Kaiser,Afra Anjum,Leo Nicolai

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Research Article September 4 2025

A bispecific nanobody for the treatment of von Willebrand disease type 1

Ivan Peyron,Caterina Casari,Genevieve McCluskey,Stéphanie Roullet,Vincent N Licari,Emilie Bocquet,Claire Auditeau,Melanie Y Daniel,Sophie Susen,Olivier D. Christophe,Peter J Lenting,Cécile V. Denis

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Research Article September 3 2025

Off-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk KMT2A-rearranged leukemia

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Research Article September 2 2025

The Origin, Diagnosis, and Prognosis of Oligomannose-Type Diffuse Large B-Cell Lymphoma

Dylan James Tatterton,Maddy L Newby,Joel D Allen,Benjamin J Sale,Giorgia Chiodin,Patrick J Duriez,John Butler,Katy J McCann,David W. Scott,Ryan D Morin,Kostiantyn Dreval,Andrew J Davies,Dean Bryant,Max Crispin,Francesco Forconi

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Research Article September 2 2025

Nanoromidepsin, a Polymer Nanoparticle of the HDAC Inhibitor, Improves Safety and Efficacy in Models of T-cell Lymphoma

Ipsita Pal,Anuradha Illendula,Andrea Megan Joyner,John Sanil Manavalan,Tess M Deddens,Ariana Sabzevari,Deepthi P Damera,Samir Zuberi,Enrica Marchi,Todd E Fox,Marya Dunlap Brown,Kallesh Danappa Jayappa,Jihane Khalife,Jeffrey W. Craig,Thomas P Loughran,David J. Feith,Owen A. O'Connor

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Research Article September 2 2025

Impact of ASXL1 at diagnosis in patients with CML receiving frontline potent TKIs: high risk of kinase domain mutations

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Research Article August 27 2025

Targeting FXR in Hepatocytes: A Promising Approach to Enhance Fibrinolysis and Reduce Deep Vein Thrombosis Risk

Bolin Li,Heze Fan,Hao Wu,Yiqiong Zhang,Ning Ding,Peining Liu,Qi Wang,Miaomiao Cao,Zixuan Meng,Xinxin Feng,Xiaozhen Zhuo,Wei Wu,Ying Xiong,Kai Deng,Ting Li,Junhui Liu,Yue Wu

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