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Journal Articles

Impact of ASXL1 at diagnosis in patients with CML receiving frontline potent TKIs: high risk of kinase domain mutations

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Naranie Shanmuganathan, David T. Yeung, Carol Wadham, Adelina Fernandes, Muneeza Maqsood, NurHezrin Shahrin, Verity Saunders, Rosalie R. Kenyon, Ming Lin, John Toubia, Joe McConnell, Dominic Kaczorowski, David M. Ross, Agnes S. M. Yong, Lynette Chee, Jake Shortt, Nicholas Viiala, Jodi Braley, Chung Hoow Kok, Timothy P. Hughes, Susan Branford
Journal: Blood
Blood (2025) 146 (23): 2821–2832.
https://doi.org/10.1182/blood.2025030259
Published: 2025
Includes: Supplemental data
Journal Articles

Somatic mutations at diagnosis in patients with chronic Phase CML receiving frontline imatinib are associated with a higher rate of treatment failure: First analysis from the international CML foundation (iCMLf) genomics alliance on the harmony platform

Free
Susan Branford, Ali Albeer, Ángela Villaverde Ramiro, Joe McConnell, María Abáigar, Jenny Rinke, Katerina Machova Polakova, Jiri Mayer, Ruth Stuckey, Mohamed Yassin, Lee-Yung Shih, Ahmad Alhuraiji, Carlo Gambacorti-Passerini, Dennis Kim, Sin Tiong Ong, Tomasz Stoklosa, Jitka Krizkova, Adam Laznicka, Ivana Jeziskova, María Teresa Gómez Casares, Susanna Akiki, Mahmoud Hasaneen, Federica Colombo, Charles Chuah, Monika Pępek, Ángela Rodríguez, Ana Garcia, Markus Pfirrmann, Nicola Evans, Andreas Hochhaus, Timothy Hughes, Chung Hoow Kok, Thomas Ernst
Journal: Blood
Blood (2025) 146 (Supplement 1): 75.
https://doi.org/10.1182/blood-2025-75
Published: 2025
Journal Articles

Integrated prognostic model for TP53‑mutated myeloid neoplasms across all myeloid neoplasm subtypes

Free
Devendra Hiwase, Steven Tessier, Kevin Hung, Rong He, Maymona Abdelmagid, Danielle Rud, Michelle Maritz, Aref Al-Kali, Naseema Gangat, Mrinal Patnaik, Abhishek Mangaonkar, Hosein Anani, Antoine Saliba, Nathan Punwani, James Foran, Dong Chen, Emmanuel Gnanamanickam, Hassan Alkhateeb, Dariusz Ladon, Monika Kutyna, Kebede Begna, Hamish Scott, Mehrdad Hefazi Torghabeh, Aasiya Matin, Kaaren Reichard, Cinthya Zepeda, Chris Hahn, William Hogan, Attilio Orazi, Daniel Arber, Chung Hoow Kok, Mithun Shah, Ayalew Tefferi
Journal: Blood
Blood (2025) 146 (Supplement 1): 2087.
https://doi.org/10.1182/blood-2025-2087
Published: 2025
Journal Articles

Strong Association between Cancer Gene Variants at Diagnosis, Especially ASXL1 , and Emergence of Kinase Domain Mutation-Driven Resistance in CML Patients Despite Frontline Treatment with More Potent BCR::ABL1 Inhibitors

Free
Naranie Shanmuganathan, Carol Wadham, David T Yeung, Nur Hezrin Shahrin, Adelina Fernandes, Muneeza Maqsood, Chung Hoow Kok, Verity A Saunders, Ilaria Stefania Pagani, Rosalie Kenyon, Ming Lin, David M Ross, Timothy P Hughes, Susan Branford
Journal: Blood
Blood (2024) 144 (Supplement 1): 991.
https://doi.org/10.1182/blood-2024-199899
Published: 2024
Journal Articles

Longitudinal Clonal Tracking Reveals That Early and Sensitive Detection of Blood Cancer-Related Gene Variants in Patients with Chronic Myeloid Leukemia Predicts Treatment Failure

Free
Susan Branford, Adelina Fernandes, Carol Wadham, Muneeza Maqsood, Nur Hezrin Shahrin, David M Ross, Agnes S. M. Yong, Ming Lin, Rosalie Kenyon, Dominik Kaczorowski, Verity A Saunders, Ilaria Stefania Pagani, John Toubia, Joe McConnell, David T Yeung, Chung Hoow Kok, Timothy P Hughes, Naranie Shanmuganathan
Journal: Blood
Blood (2024) 144 (Supplement 1): 996.
https://doi.org/10.1182/blood-2024-198827
Published: 2024
Journal Articles

Evidence-Based Risk Stratification of TP53 -Mutated Myeloid Neoplasms

Free
Mithun V Shah, Kevin Hung, Anmol Baranwal, Zoe Price, Aref Al-Kali, Carla Toop, Patricia Greipp, Anna Brown, Dariusz Ladon, Dong Chen, Kebede Begna, Monika Kutyna, Danielle Rud, Mark R. Litzow, William J. Hogan, Peter Bardy, Talha Badar, Sharad Kumar, David T Yeung, Mrinal M. Patnaik, James M. Foran, Rong He, Naseema Gangat, Hamish S Scott, Cecilia Y. Arana Yi, Hassan B Alkhateeb, Abhishek A. Mangaonkar, Daniel Thomas, Christopher N. Hahn, Attilio Orazi, Daniel A. Arber, Chung Hoow Kok, Ayalew Tefferi, Devendra Hiwase
Journal: Blood
Blood (2024) 144 (Supplement 1): 3213.
https://doi.org/10.1182/blood-2024-198269
Published: 2024
Journal Articles

TP53 -Mutated Therapy-Related Myeloid Neoplasms Are Associated with a Long Latency and Are More Prevalent in Patients with Primary Hematological Cancers Compared to Solid Tumors

Free
Kevin Hung, Aref Al-Kali, Carla Toop, Mrinal M. Patnaik, Zoe Price, Taxiarchis Kourelis, Daniel Thomas, Morie A. Gertz, Hossein Anani, Wilson I. Gonsalves, Chung Hoow Kok, Ayalew Tefferi, Devendra Hiwase, Mithun V Shah
Journal: Blood
Blood (2024) 144 (Supplement 1): 4594.
https://doi.org/10.1182/blood-2024-211931
Published: 2024
Journal Articles

Increased Inflammatory Cytokines in Plasma Are Associated with Sustained Treatment-Free Remission in Chronic Myeloid Leukaemia

Free
Chung Hoow Kok, Verity A Saunders, Naranie Shanmuganathan, Liu Liu, Yazad Daruis Irani, Jade Clarson, Phuong Dang, David T Yeung, Agnes S. M. Yong, Susan Branford, Javier Pinilla-Ibarz, Richard A. Larson, Jorge E. Cortes, Michael J. Mauro, James E Thompson, Neil P. Shah, Martha Wadleigh, Ehab L. Atallah, Jerald P. Radich, Timothy P Hughes, David M Ross
Journal: Blood
Blood (2024) 144 (Supplement 1): 993.
https://doi.org/10.1182/blood-2024-201881
Published: 2024
Journal Articles

IDH -mutant myeloid neoplasms are associated with seronegative rheumatoid arthritis and innate immune activation

Free
Lih En Hong, Mihir D. Wechalekar, Monika Kutyna, Annabelle Small, Kelly Lim, Chloe Thompson-Peach, Joule J. Li, Rakchha Chhetri, Hamish S. Scott, Anna Brown, Christopher N. Hahn, David T. Yeung, Salvia Sajid, Nirmal Robinson, Ranjeny Thomas, Susan Branford, Richard J. D’Andrea, Saumya E. Samaraweera, Mrinal Patnaik, Susanna Proudman, Daniel Thomas, Chung Hoow Kok, Mithun V. Shah, Devendra K. Hiwase
Journal: Blood
Blood (2024) 143 (18): 1873–1877.
https://doi.org/10.1182/blood.2023023593
Published: 2024
Includes: Supplemental data
Journal Articles

Comparison of World Health Organization and International Consensus Classification Guidelines for Myeloid Neoplasms Harboring TP53 -Mutations Using an Independent International Cohort

Free
Mithun V Shah, Monika Kutyna, Syed Shah, Elizabeth Ngoc Hoa Tran, Anmol Baranwal, Dariusz Ladon, Aref Al-Kali, Anna Brown, Dong Chen, Patricia Greipp, Kebede Begna, Mark R. Litzow, William J. Hogan, Peter Bardy, Sharad Kumar, David T Yeung, Mrinal M. Patnaik, James M. Foran, Rong He, Naseema Gangat, Hamish S Scott, Cecilia Y. Arana Yi, Hassan Alkhateeb, Abhishek A Mangaonkar, Daniel Thomas, Christopher Norman Hahn, Attilio Orazi, Daniel A. Arber, Chung Hoow Kok, Ayalew Tefferi, Devendra Hiwase
Journal: Blood
Blood (2023) 142 (Supplement 1): 3243.
https://doi.org/10.1182/blood-2023-187860
Published: 2023
Journal Articles

Age-Related Clonal Hematopoiesis Mutations Detected at the Time of Stopping Tyrosine Kinase Inhibitor Therapy Predict the Achievement of Treatment-Free Remission for Patients with CML

Free
Susan Branford, Carol Wadham, Naranie Shanmuganathan, Adelina Fernandes, Nur Hezrin Shahrin, Jinghua Feng, John Toubia, Paul Wang, Chung Hoow Kok, Muneeza Maqsood, Verity Saunders, Rob King, Ming Lin, Rosalie Kenyon, Ilaria Stefania Pagani, David T Yeung, David M. Ross, Agnes S. M. Yong, Timothy P Hughes
Journal: Blood
Blood (2023) 142 (Supplement 1): 447.
https://doi.org/10.1182/blood-2023-174425
Published: 2023
Journal Articles

High Prevalence of IDH Mutation in Myeloid Neoplasm with Concomitant Autoimmune Rheumatic Disorders

Free
Lih En Hong, Chung Hoow Kok, Monika Kutyna, Joule J Li, Rakchha Chhetri, David M. Ross, Susan Branford, Hamish S Scott, Anna Brown, Christopher Norman Hahn, David T Yeung, Mrinal M. Patnaik, Mithun V Shah, Susanna Proudman, Mihir Wechalekar, Devendra Hiwase
Journal: Blood
Blood (2023) 142 (Supplement 1): 4621.
https://doi.org/10.1182/blood-2023-190809
Published: 2023
Journal Articles

Single-Hit TP53 mut Is Associated with Poor Outcomes in Therapy-Related but Not De Novo Myelodysplastic Syndromes: Importance of Clinical History

Free
Devendra Hiwase, Anmol Baranwal, Syed Shah, Monika Kutyna, Christopher Norman Hahn, Maymona Abdelmajid, Danielle Rud, Rakchha Chhetri, Kaaren K. Reichard, Dong Chen, Thomas Wiseman, Anna Brown, Hamish S Scott, David T Yeung, David M. Ross, Daniel Thomas, Aref Al-Kali, Hassan Alkhateeb, James M. Foran, Cecilia Y. Arana Yi, Naseema Gangat, Mrinal M. Patnaik, Ayalew Tefferi, Chung Hoow Kok, Rong He, Mithun V Shah
Journal: Blood
Blood (2023) 142 (Supplement 1): 4608.
https://doi.org/10.1182/blood-2023-187905
Published: 2023
Journal Articles

Clonal Hematopoiesis Detected at the Time of Tyrosine Kinase Inhibitor Cessation Is Associated with Delayed Molecular Recurrence after Treatment-Free Remission in Patients with CML

Free
Susan Branford, Naranie Shanmuganathan, Carol Wadham, Nur Hezrin Shahrin, Adelina Fernandes, Jinghua Feng, Andreas W Schreiber, Chung Hoow Kok, Verity A Saunders, Rob King, Ming Lin, Ilaria S Pagani, David T Yeung, David M Ross, Agnes S.M. Yong, Timothy Hughes
Journal: Blood
Blood (2022) 140 (Supplement 1): 3916–3917.
https://doi.org/10.1182/blood-2022-158735
Published: 2022
Journal Articles

TP53 Mutation Status Defines a Distinct Clinicopathological Entity of Therapy-Related Myeloid Neoplasm, Characterized By Genomic Instability and Extremely Poor Outcome

Free
Mithun V. Shah, Christopher N Hahn, Elizabeth Ngoc Hoa Tran, Kirsty M Sharplin, Rakchha Chhetri, Anmol Baranwal, Monika M Kutyna, Paul Wang, Dariusz Ladon, Aref Al-Kali, Hassan B. Alkhateeb, David M Ross, David T Yeung, Naranie Shanmuganathan, Mark R. Litzow, Abhishek A. Mangaonkar, William J. Hogan, Naseema Gangat, Mrinal M.M. Patnaik, Begna Kebede, Sharad Kumar, Deepak Singhal, Anna L. Brown, Hamish S Scott, Daniel Thomas, Chung Hoow Kok, Ayalew Tefferi, Devendra Hiwase
Journal: Blood
Blood (2022) 140 (Supplement 1): 9798–9799.
https://doi.org/10.1182/blood-2022-165859
Published: 2022
Journal Articles

A Risk Model for CML Patients with COVID-19: Importance of Molecular Response in the Context of Age, Comorbidities and Country Income

Free
Jerald P. Radich, Chung Hoow Kok, Ekaterina Yu. Chelysheva, Jorge E. Cortes, Qian Jiang, Michael Mauro, Dragana Milojkovic, Beatriz Moiraghi, Franck E. Nicolini, Matilda Ongondi, Katia B Pagnano, Daniela Žácková, Delphine Rea, Nicola Evans, Timothy Hughes
Journal: Blood
Blood (2022) 140 (Supplement 1): 9617–9619.
https://doi.org/10.1182/blood-2022-165855
Published: 2022
Journal Articles

Integrated Personalized Prediction Model Identifies a Subgroup of Wild-Type TP53 therapy-Related Myeloid Neoplasm Patients with Poor Outcome

Free
Mithun V. Shah, Christopher N Hahn, Rakchha Chhetri, Elizabeth Ngoc Hoa Tran, Deepak Singhal, William J. Hogan, Monika M Kutyna, Hassan B. Alkhateeb, Aref Al-Kali, Naseema Gangat, Mark R. Litzow, Begna Kebede, Abhishek A. Mangaonkar, Mrinal M. Patnaik, Ayalew Tefferi, Anmol Baranwal, Naranie Shanmuganathan, Sharad Kumar, Daniel Thomas, Chung Hoow Kok, Devendra Hiwase
Journal: Blood
Blood (2022) 140 (Supplement 1): 6964–6965.
https://doi.org/10.1182/blood-2022-168349
Published: 2022
Journal Articles

Personalized Prediction Model to Risk Stratify Patients with Therapy-Related Myeloid Neoplasms

Free
Chung Hoow Kok, Elizabeth Ngoc Hoa Tran, Dariusz Ladon, Rakchha Chhetri, Anmol Baranwal, Kirsty M Sharplin, Hassan B. Alkhateeb, Deepak Singhal, Aref Al-Kali, Naseema Gangat, David T Yeung, Mark R. Litzow, David M Ross, William J. Hogan, Ashanka Begna Kebede, Abhishek A. Mangaonkar, Mrinal M. Patnaik, Ayalew Tefferi, Naranie Shanmuganathan, Sharad Kumar, Daniel Thomas, Mithun V. Shah, Devendra Hiwase
Journal: Blood
Blood (2022) 140 (Supplement 1): 6962–6963.
https://doi.org/10.1182/blood-2022-167978
Published: 2022
Journal Articles

Senolytic Therapy Can Reverse Senescent Bone Marrow Stroma of Therapy-Related Myeloid Neoplasm

Free
Monika M Kutyna, Chung Hoow Kok, Yoon Lim, David Campbell, Sharon Paton, Chloe AL Thompson-Peach, Kelly SY Lim, Timothy Hughes, Sharad Kumar, Daniel Thomas, Stan Gronthos, Devendra Hiwase
Journal: Blood
Blood (2022) 140 (Supplement 1): 9755–9756.
https://doi.org/10.1182/blood-2022-167994
Published: 2022
Journal Articles

Highly Sensitive Droplet Digital PCR to Identify CML Patients with a High Probability of Achieving Treatment-Free Remission

Free
Liu Lu, Phuong Dang, Chung Hoow Kok, Verity A Saunders, Susan Branford, Timothy P. Hughes, David T Yeung
Journal: Blood
Blood (2021) 138 (Supplement 1): 2559.
https://doi.org/10.1182/blood-2021-151966
Published: 2021