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David Fandrei
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Journal Articles

Spatiotemporal and genetic tracking of long-term persisting CAR-T cells following ciltacabtagene autoleucel treatment for multiple myeloma reveals molecular insights into late-onset toxicities

Free
David Fandrei, Sabine Seiffert, Christina Kuhn, Michael Rade, Esmée van Vliet, Vera von Landenberg-Roberg, Manja Meggendorfer, Luise Fischer, Markus Kreuz, Dennis Löffler, Conny Blumert, Anja Grahnert, Maik Friedrich, Patrick Born, Thomas Wiemers, Emilie-Charlot Skerbek, Kathrin Jäger, Sebastian Greiser, Ronny Baber, Song-Yau Wang, Simone Heyn, Georg-Nikolaus Franke, Andreas Boldt, Dominik Schmiedel, Sebastian Böttcher, Marco Herling, Jurgen Kuball, Marietta Truger, Torsten Haferlach, Jan Krönke, Uwe Platzbecker, Klaus Metzeler, Ulrike Koehl, Vladan Vucinic, Zsolt Sebestyen, Kristin Reiche, Maximillian Merz
Journal: Blood
Blood (2025) 146 (Supplement 1): 690.
https://doi.org/10.1182/blood-2025-690
Published: 2025
Journal Articles

Clonal persistence of BRAFV600E under MEK inhibition in histiocytosis

Free
Marzieh Nashvi, David Fandrei, Florian Houdu, Paul Quentric, Irena Ungureanu, Matthias Papo, Lise Drouart, Marion Peyre, Jessica Rengassamy, Zofia Hélias-Rodzewicz, Nathalie Droin, Rémy Jélin, Cyril Quivoron, Stephane De Botton, Jean Donadieu, Jean-Francois Emile, Elsa Bernard, Sébastien Héritier, Julien Haroche, Camille Bigenwald
Journal: Blood
Blood (2025) 146 (Supplement 1): 1495.
https://doi.org/10.1182/blood-2025-1495
Published: 2025
Journal Articles

Sarcopenia and body composition predict survival and reveal immunometabolic dysfunction via single-cell profiling in anti-BCMA CAR T-treated myeloma

Free
Thomas Wiemers, Michael Rade, Nora Grieb, Maximilian Ferle, Tihomir Dermendzhiev, David Fandrei, Patrick Born, Sabine Seiffert, Anja Grahnert, Maik Friedrich, Ronny Baber, Markus Kreuz, Klaus Metzeler, Marco Herling, Carmen Herling, Madlen Jentzsch, Georg-Nikolaus Franke, Andreas Boldt, Ulrike Koehl, Kristin Reiche, Timm Denecke, Urvi Shah, Uwe Platzbecker, Vladan Vucinic, Hans-Jonas Meyer, Maximilian Merz
Journal: Blood
Blood (2025) 146 (Supplement 1): 7676.
https://doi.org/10.1182/blood-2025-7676
Published: 2025
Journal Articles

Impact of renal impairment and lymphodepletion regimen on outcomes after CAR T-cell therapy in relapsed/refractory multiple myeloma

Free
Nora Grieb, Thomas Wiemers, Patrick Born, David Fandrei, Luise Fischer, Maximilian Ferle, Song-Yau Wang, Madlen Jentzsch, Carmen Herling, Klaus Metzeler, Marco Herling, Simone Heyn, Uwe Platzbecker, Vladan Vucinic, Thomas Neumuth, Georg-Nikolaus Franke, Maximilian Merz
Journal: Blood
Blood (2025) 146 (Supplement 1): 5853.
https://doi.org/10.1182/blood-2025-5853
Published: 2025
Journal Articles

CAR T-cells or bispecific antibodies for relapsed/refractory multiple myeloma: Head-to-head real-world european comparison

Free
Maximilian Merz, Tomas Jelinek, Thomas Pabst, Raphael Teipel, Anca-Maria Albici, Bastian von Tresckow, Marcel Teichert, Uta Demel, Antonia Busse, Marie Wesener, Tobias A.W. Holderried, Friederike Schmitz, Fabian Müller, Friedrich-Linus Roessiger, Barbara Jeker, Michele Hoffmann, Natalie Schub, Natalia Tovar, Ben-Niklas Baermann, Stork Martin, Alexandra Jungova, Jiri Minarik, Jakub Radocha, Ivan Špička, Ludek Pour, Polona Novak, Klara Slajpah, Karla Rener, Matjaz Sever, Ulrich Keller, Stephan Bohl, Francis Ayuk, David Fandrei, Patrick Born, Vladan Vucinic, Nicolaus Kroeger, Irene Strassl, Friedrich Stoelzel, Roman Hajek, Carlos Fernandez de Larrea, Nico Gagelmann
Journal: Blood
Blood (2025) 146 (Supplement 1): 4590.
https://doi.org/10.1182/blood-2025-4590
Published: 2025
Journal Articles

Prospective monitoring of 591 cancer patients with clonal hematopoiesis detected in daily practice

Free
Mégane Tanguay, David Fandrei, Michael Degaud, Ahmadreza Arbab, Romain Loyaux, Damien Vasseur, Arnaud Bayle, Mihaela Aldea, Véronique Vergé, Gérôme Jules-Clément, Sofiane Taleb, Christophe Willekens, Florence Pasquier, Cristina Castilla-Llorente, Camille Bigenwald, David Ghez, Alice Fievet, Eric Solary, Stephane De Botton, Fabrice Barlesi, Fabrice André, Ludovic Lacroix, Etienne Rouleau, Antoine Italiano, Christophe Marzac, Elsa Bernard, Aline Renneville, Jean-Baptiste Micol
Journal: Blood
Blood (2025) 146 (Supplement 1): 6708.
https://doi.org/10.1182/blood-2025-6708
Published: 2025
Journal Articles

Sequential targeting in multiple myeloma: talquetamab, a GPRC5D bispecific antibody, as a bridge to BCMA CAR-T therapy

Available to Purchase
Clinical Trials & Observations
Binod Dhakal, Othman S. Akhtar, David Fandrei, Alexandria Jensen, Rahul Banerjee, Darren Pan, Shambavi Richard, Reed Friend, Matthew Rees, Patrick Costello, Mariola Vazquez Martinez, Oren Pasvolsky, Charlotte Wagner, James A. Davis, Omar Castaneda Puglianini, Ran Reshef, Aimaz Afrough, Danai Dima, Manisha Bhutani, Omar Nadeem, Ricardo Parrondo, Ciara Freeman, Lekha Mikkilineni, Shahzad Raza, Larry D. Anderson Jr, Prashant Kapoor, Hitomi Hosoya, Saurabh Chhabra, Ariel Grajales-Cruz, Mahmoud Gaballa, Shonali Midha, Melissa Alsina, Douglas Sborov, Krina Patel, Yi Lin, Christopher Ferreri, Nico Gagelmann, Anupama Kumar, Doris Hansen, Andrew Cowan, Luciano J. Costa, Maximilian Merz, Surbhi Sidana
Journal: Blood
Blood (2025) 146 (17): 2063–2072.
https://doi.org/10.1182/blood.2025029773
Published: 2025
Includes: Supplemental data
Journal Articles

Prevalence and Mutational Make-up of Secondary Hematologic Neoplasms in Multiple Myeloma Patients after CAR-T Cell Therapy

Free
Johannes Waldschmidt, Maximilian Merz, Judith S. Hecker, Franz Reinhard, Benjamin GT Shibru, Marion Hoegner, Anna Gebauer, David Fandrei, Manja Meggendorfer, Marietta Truger, Johannes Jung, Daniel Teschner, Max S. Topp, Anna Purcarea, Vladan Vucinic, Martin K. Kortüm, Torsten Haferlach, Florian Bassermann, Uwe Platzbecker, Hermann Einsele, Claudia Haferlach, Klaus H Metzeler, Katharina S. S. Götze, Leo Rasche
Journal: Blood
Blood (2024) 144 (Supplement 1): 4688.
https://doi.org/10.1182/blood-2024-210233
Published: 2024
Journal Articles

Persistent Thrombocytopenia and Neutropenia Are Associated with Increased Mortality in Patients Treated with Anti-BCMA CAR T Cells for Relapsed/Refractory Multiple Myeloma

Free
Thomas C Wiemers, David Fandrei, Sabine Seiffert, Michael Rade, Susanne Rieprecht, Patrick Born, Markus Kreuz, Luise Fischer, Ronny Baber, Song Yau Wang, Enrica Bach, Sandra Hoffmann, Klaus H Metzeler, Marco Herling, Madlen Jentzsch, Georg-Nikolaus Franke, Ulrike Köhl, Maik Friedrich, Andreas Boldt, Kristin Reiche, Uwe Platzbecker, Vladan Vucinic, Maximilian Merz
Journal: Blood
Blood (2024) 144 (Supplement 1): 7095.
https://doi.org/10.1182/blood-2024-202101
Published: 2024
Journal Articles

Cellular Composition and Clinical Factors Influencing Manufacturing Outcomes for Anti-BCMA CAR T Cell Therapy in a Large Real-World Cohort of Relapsed/Refractory Multiple Myeloma

Free
Vladan Vucinic, David Fandrei, Janine Kirchberg, Enrica Bach, Mandy Brueckner, Kathleen Friedrich, Carmen Herling, Madlen Jentzsch, Georg-Nikolaus Franke, Simone Heyn, Uwe Platzbecker, Maximilian Merz
Journal: Blood
Blood (2024) 144 (Supplement 1): 2094.
https://doi.org/10.1182/blood-2024-207117
Published: 2024
Journal Articles

Efficacy of Anti-BCMA CAR-T Cell Therapies in Multiple Myeloma Patients with Prior Exposure to Bispecific Antibodies- Results from a Retrospective Multi-Center Registry Analysis

Free
Johannes Waldschmidt, David Fandrei, Vladan Vucinic, Ralph Wäsch, Axel Nogai, Winfried Alsdorf, Annamaria Brioli, Evgenii Shumilov, Fabian Mueller, Raphael Teipel, Nico Gagelmann, Monika Engelhardt, Jan Krönke, Julia Mersi, Michael Hudecek, Martin K. Kortüm, Uwe Platzbecker, Hermann Einsele, Max S. Topp, Leo Rasche, Maximilian Merz
Journal: Blood
Blood (2024) 144 (Supplement 1): 2007.
https://doi.org/10.1182/blood-2024-210451
Published: 2024
Journal Articles

The Differences between Ide-Cel and Cilta-Cel in Relapsed Myeloma at Single Cell Resolution

Free
David Fandrei, Michael Rade, Markus Kreuz, Luise Fischer, Patrick Born, Sabine Seiffert, Andreas Boldt, Jonathan Scolnick, Lakshmi Venkatraman, Stacy Xu, Ronny Baber, Song Yau Wang, Enrica Bach, Sandra Hoffmann, Klaus H Metzeler, Marco Herling, Madlen Jentzsch, Georg-Nikolaus Franke, Ulrike Köhl, Uwe Platzbecker, Vladan Vucinic, Kristin Reiche, Maximilian Merz
Journal: Blood
Blood (2024) 144 (Supplement 1): 1877.
https://doi.org/10.1182/blood-2024-210746
Published: 2024
Journal Articles

Mutational Profile and Dynamics of PPM1D -Mutant Clones in the Spectrum of Myeloid Disorders

Free
Jean Pegliasco, David Fandrei, Florence Pasquier, Nathalie Ibrahim, Maria Kfoury, Guillemette Imbert-De-Tremiolles, Nourhan Lizziek, Céline Berthon, Mael Heiblig, Delphine Lebon, Ambroise Marcais, Mathieu Meunier, Ahmad Aljijakli, Emilie Lemasle, Sylvain Chantepie, Cécile Pautas, Pierre-Yves Dumas, Stephanie Haiat, Cyril Quivoron, Ileana antony-Debre, Sophie Cotteret, Raphael Itzykson, Hervé Dombret, Nicolas Duployez, Nathalie Droin, Christophe Marzac, Elsa Bernard, Jean-Baptiste Micol
Journal: Blood
Blood (2023) 142 (Supplement 1): 4064.
https://doi.org/10.1182/blood-2023-189428
Published: 2023
Journal Articles

Lymphopenia Confers Poorer Prognosis in Myelodysplastic Neoplasms (MDS) with Very Low and Low IPSS-M

Free
David Fandrei, Tony Huynh, Marie Sebert, Lorea Aguinaga, Valeria Bisio, Marion Espéli, Karl Balabanian, Hélène Moins-Teisserenc, Antoine Toubert, Nicolas Dulphy, Pierre Fenaux, Lionel Ades, Lin-Pierre Zhao
Journal: Blood
Blood (2023) 142 (Supplement 1): 4597.
https://doi.org/10.1182/blood-2023-187707
Published: 2023