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Journal Articles

Upregulation of BCMA expression by selinexor

Free
Christina Verbruggen, Umair Munawar, Seungbin Han, Julia Mersi, Emma Besant, Shilpa Kurian, Silvia Nerreter, Nina Rein, Johanna Lehmann, Max Koeppel, Hermann Einsele, Leo Rasche, Johannes Waldschmidt, K. Martin Kortüm
Journal: Blood
Blood (2025) 146 (Supplement 1): 6102.
https://doi.org/10.1182/blood-2025-6102
Published: 2025
Journal Articles

Modeling of a hyper-inflammatory hematopoietic niche ex vivo reveals a multi-step process driving CAR T- cell associated myeloid leukemia in multiple myeloma

Free
Max Köppel, Umair Munawar, Shilpa Kurian, Manja Meggendorfer, Marietta Truger, Silvia Nerreter, Seungbin Han, Christina Verbruggen, Emma Besant, Nina Rein, Johanna Lehmann, Ann-Sophie Hainold, Torsten Steinbrunn, Jennifer Wing Lam Cheung, Dominic Grün, Michael Hudecek, Satu Mustjoki, Mikko Myllymäki, Konstantin Matjusinski, Hermann Einsele, Leo Rasche, K. Martin Kortüm, Johannes Waldschmidt
Journal: Blood
Blood (2025) 146 (Supplement 1): 2152.
https://doi.org/10.1182/blood-2025-2152
Published: 2025
Journal Articles

Short survival with BCMA and GPRC5D dual antigen exposed relapsed myeloma- an international myeloma working group immunotherapy database analysis

Free
Murali Janakiram, Thomas Martin, Mrugakshi Dave, Chiung-Yu Huang, Sireesha Asoori, Myo Htut, Andre De Menezes Silva Corraes, Prashant Kapoor, Chris Lau Wai Pan, Carlyn Tan, Saad Usmani, Hira Mian, Roman Hajek, Efstathios Kastritis, Susan Bal, Joaquin Martinez-Lopez, Andrew Cowan, Chandramouli Nagarajan, Wee-Joo Chng, Allison Tso, Hermann Einsele, Amrita Krishnan, Rakesh Popat, Yi Lin, Darren Pan
Journal: Blood
Blood (2025) 146 (Supplement 1): 4598.
https://doi.org/10.1182/blood-2025-4598
Published: 2025
Journal Articles

Plasmapheresis facilitates soluble BCMA clearance and contributes to reversing primary resistance to anti-BCMA immunotherapy in multiple myeloma

Free
Umair Munawar, Sven Neubert, Julia Mersi, Julia Norderer, Silvia Nerreter, Shilpa Kurian, Seungbin Han, Christina Verbruggen, Emma Besant, Nina Rein, Max Koeppel, Johanna Lehmann, Tabea Koehler, Hannah Labinsky, Sigrun Haeusl, Yoko Tamamushi, Xiang Zhou, Jule Pinter, Anna Laura Herzog, Kai Lopau, Elion Hoxha, Christoph Rummelt, Elena Gerhard-Hartmann, Andreas Rosenwald, Torsten Steinbrunn, Thomas Nerreter, Michael Hudecek, Hermann Einsele, Leo Rasche, K. Martin Kortüm, Johannes Waldschmidt
Journal: Blood
Blood (2025) 146 (Supplement 1): 7465.
https://doi.org/10.1182/blood-2025-7465
Published: 2025
Journal Articles

Antigen-dependent clonal sweep with sequential or combinatory anti-myeloma T cell engagers

Free
Holly Lee, Sungwoo Ahn, Deeksha Vishwamitra, Sheri Skerget, Mansour Poorebrahim, Noemie Leblay, Elham Hasheminasabgo, Sacha Benaoudia, David Jung, Sejal Chikhale, Kostantina Taouxi, Hermann Einsele, Efstathios Kastritis, Marc Raab, Francesco Maura, Leo Rasche, Jill Corre, Herve Avet-Loiseau, Paola Neri, Nizar Bahlis
Journal: Blood
Blood (2025) 146 (Supplement 1): 1030.
https://doi.org/10.1182/blood-2025-1030
Published: 2025
Journal Articles

An acquired immune-metabolic shift to common chemotherapy confers resistance to immunotherapies in relapsed, high-risk multiple myeloma

Free
Mara John, Nazia Afrin, Emilia Stanojkovska, Hanna Fischer, Maximilian Krämer, Werner Schmitz, Lars Grundheber, Moutaz Helal, Silvia Nerreter, Cornelia Vogt, Shilpa Kurian, Xiang Zhou, Max Steinhardt, Benedict Engel, Anni Hofmann, Julia Mersi, Johannes Waldschmidt, Hermann Einsele, K. Martin Kortüm, Leo Rasche, Angela Riedel
Journal: Blood
Blood (2025) 146 (Supplement 1): 3938.
https://doi.org/10.1182/blood-2025-3938
Published: 2025
Journal Articles

Clinical, anatomic, and histologic determinants of gastrointestinal disease burden and survival in systemic AL amyloidosis: A cohort study of 560 patients

Free
Max Steinhardt, Eli Muchtar, Taxiarchis Kourelis, Rahma Warsame, Michelle Mauermann, Francis Buadi, David Dingli, Nelson Leung, Joselle Cook, Ronald Go, Suzanne Hayman, Wilson Gonsalves, Prashant Kapoor, Saurabh Zanwar, Moritz Binder, Tamer Hellou, Melinda Tan, Amie Fonder, Miriam Hobbs, Nadine Abdallah, Yi Lin, Mustaqeem Siddiqui, Robert Kyle, Hermann Einsele, S. Vincent Rajkumar, Shaji Kumar, K. Martin Kortüm, Morie Gertz, Angela Dispenzieri
Journal: Blood
Blood (2025) 146 (Supplement 1): 3962.
https://doi.org/10.1182/blood-2025-3962
Published: 2025
Journal Articles

Single-cell profiling reveals teclistamab-induced reshaping of nasopharyngeal immunity in multiple myeloma

Free
Sofie-Katrin Kadel, Alexander Leipold, Philipp Weis, Tobias Krammer, Lukas Scheller, Julia Mersi, Nazia Afrin, Johannes Waldschmidt, K. Martin Kortüm, Hermann Einsele, Antoine-Emmanuel Saliba, Leo Rasche
Journal: Blood
Blood (2025) 146 (Supplement 1): 5698.
https://doi.org/10.1182/blood-2025-5698
Published: 2025
Journal Articles

Reprogrammed regulatory T cells as cytotoxic effectors drive anti-tumor immunity under bispecific T cell engager therapy

Free
Julius Michel, Jan Frenking, Anna Metzler, Erin Meermeier, Antonia Schach, Vera Thiel, Tim Wagner, Niklas Kehl, Stefanie Huhn, Alexander Brobeil, Carsten Müller-Tidow, P. Leif Bergsagel, Hartmut Goldschmidt, Hermann Einsele, Leo Rasche, Marta Chesi, Marc Raab, Niels Weinhold, Mirco Friedrich
Journal: Blood
Blood (2025) 146 (Supplement 1): 3951.
https://doi.org/10.1182/blood-2025-3951
Published: 2025
Journal Articles

NQO1 modulates CD38 surface expression in multiple myeloma

Free
Seungbin Han, Christina Verbruggen, Silvia Nerreter, Umair Munawar, Shilpa Kurian, Emma Besant, Ann-Sophie Hainold, Cornelia Vogt, Xiang Zhou, Hermann Einsele, Leo Rasche, Markus Sauer, Johannes Waldschmidt, K. Martin Kortüm
Journal: Blood
Blood (2025) 146 (Supplement 1): 5718.
https://doi.org/10.1182/blood-2025-5718
Published: 2025
Journal Articles

Talquetamab alters T cell transcriptome in presence of GPRC5D on MM cells

Free
Umair Munawar, Alexander Leipold, Silvia Nerreter, Seungbin Han, Shilpa Kurian, Emma Besant, Nina Rein, Max Koeppel, Johanna Lehmann, Xiang Zhou, Hermann Einsele, Leo Rasche, Emmanuel Saliba, Johannes Waldschmidt, K. Martin Kortüm
Journal: Blood
Blood (2025) 146 (Supplement 1): 5701.
https://doi.org/10.1182/blood-2025-5701
Published: 2025
Journal Articles

Lattice light-sheet microscopy reveals patient specific responses to CD20-directed antibodies in B cell malignancies

Free
Julia Weingart, Patrick Eiring, Umair Munawar, Seungbin Han, Christina Verbruggen, Silvia Nerreter, Shilpa Kurian, Max Steinhardt, Leo Rasche, Hermann Einsele, Johannes Waldschmidt, K. Martin Kortüm, Markus Sauer
Journal: Blood
Blood (2025) 146 (Supplement 1): 4343.
https://doi.org/10.1182/blood-2025-4343
Published: 2025
Journal Articles

LIME: A first-in-class of live bacterial immune engagers for cancer immunotherapy

Free
Anna Clara Bader, Shaobo Yang, Ashley Hu, Stephanie Sendker, Daniel Chen, Michal Sheffer, Eden Bobilev, Fuguo Liu, Xingyu Deng, Hetal Nath, Isabel Kaplan, Maily Nyugen, Mila Stanojevic, Mubin Tarannum, Alaa Ali, Roman Shapiro, Young Rock Chung, Erin Parry, Nathalie Javidi-Sharifi, Julissa Tello, Stephanie Dougan, Hermann Einsele, Evelyn Ullrich, John Koreth, Robert Soiffer, Catherine Wu, Jerome Ritz, Rizwan Romee
Journal: Blood
Blood (2025) 146 (Supplement 1): 264.
https://doi.org/10.1182/blood-2025-264
Published: 2025
Journal Articles

Tumor intrinsic mechanisms leading to cevostamab resistance in multiple myeloma

Free
Cecilia Bonolo De Campos, Umair Munawar, Christina Verbruggen, David Scott, Dor Abelman, Silvia Nerreter, Johanna Lehmann, Seungbin Han, Mariano Arribas, Esther Masih-Khan, Laura Bruins, Ding Wang, Jeffrey Bruce, Zhihua Li, Safa Abdulsalam, Gregory Ahmann, Shaji Kumar, Esteban Braggio, Trevor Pugh, Rafael Fonseca, Leo Rasche, Hermann Einsele, Johannes Waldschmidt, K. Martin Kortüm, Keith Stewart, Suzanne Trudel
Journal: Blood
Blood (2025) 146 (Supplement 1): 2178.
https://doi.org/10.1182/blood-2025-2178
Published: 2025
Journal Articles

Impact of bortezomib on T-cell subsets and immune checkpoints under bispecific antibody therapy in multiple myeloma

Free
Xiang Zhou, Umair Munawar, Shilpa Kurian, Seungbin Han, Mara John, Hanna Fischer, Silvia Nerreter, Lenka Besse, Andrej Besse, Christoph Driessen, Marc Schmalzing, Johannes Waldschmidt, Hermann Einsele, Leo Rasche, K. Martin Kortüm
Journal: Blood
Blood (2025) 146 (Supplement 1): 2174.
https://doi.org/10.1182/blood-2025-2174
Published: 2025
Journal Articles

Novel insights in therapeutic antibody therapies using advanced microscopy techniques

Free
Christina Verbruggen, Patrick Eiring, Max Steinhardt, Julia Weingart, Umair Munawar, Seungbin Han, Sven Neubert, Emma Besant, Cornelia Vogt, Silvia Nerreter, Shilpa Kurian, Nina Rein, Johanna Lehmann, Max Koeppel, Hermann Einsele, Johannes Waldschmidt, Markus Sauer, K. Martin Kortüm
Journal: Blood
Blood (2025) 146 (Supplement 1): 6111.
https://doi.org/10.1182/blood-2025-6111
Published: 2025
Journal Articles

Endothelial dysfunction and proinflammatory state determine severe hematotoxicity and adverse outcome of CAR-T therapy

Free
Lukas Scheller, Xiang Zhou, Markus Kreuz, Henry Loeffler-Wirth, Sofie-Katrin Kadel, Sven Schimanski, Hannah Schulze, Anna Marie Ruckdeschel, Florian Eisele, Verena Konetzki, Maria Jornet Culubret, Julia Mersi, Johannes Waldschmidt, Sophia Danhof, Maximilian Merz, Ulrike Koehl, K. Martin Kortüm, Leo Rasche, Hermann Einsele, Johannes Duell, Prof. Dr. Max S Topp, Michael Hudecek, Kristin Reiche, Miriam Alb
Journal: Blood
Blood (2025) 146 (Supplement 1): 809.
https://doi.org/10.1182/blood-2025-809
Published: 2025
Journal Articles

Increased teclistamab dosing interval improves T-cell diversity and reduces infection risk, while T-cell exhaustion remains minimal irrespective of schedule

Free
Nazia Afrin, Florian Eisele, Emilia Stanojkovska, Mara John, Hanna Fischer, Moutaz Helal, Carolin Köchel, Niklas Kehl, Lars Grundheber, Philipp Weis, Christine Riedhammer, Sofie-Katrin Kadel, Julia Mersi, Torsten Steinbrunn, Johannes Waldschmidt, Sabrina Kraus, Johannes Duell, K. Martin Kortüm, Mirco Friedrich, Hermann Einsele, Angela Riedel, Leo Rasche
Journal: Blood
Blood (2025) 146 (Supplement 1): 802.
https://doi.org/10.1182/blood-2025-802
Published: 2025
Journal Articles

Real world efficacy and safety of elranatamab, a BCMA bispecific antibody for patients with relapsed and refractory multiple myeloma: An international myeloma working group immunotherapy database analysis

Free
Rakesh Popat, Oliver Morjaria, Carlyn Tan, Saad Usmani, Alissa Visram, Susan Bal, Luciano Costa, Roman Hajek, Jana Mihalyova, Joaquin Martinez-Lopez, Adolfo Sáez Marín, Meletios Dimopoulos, Efstathios Kastritis, Chandramouli Nagarajan, Shimin Jasmine Chung, Myo Htut, Wee-Joo Chng, Allison Tso, Thomas Martin, Mrugakshi Dave, Chiung-Yu Huang, Andrew Cowan, Hermann Einsele, Yi Lin, Hira Mian
Journal: Blood
Blood (2025) 146 (Supplement 1): 4588.
https://doi.org/10.1182/blood-2025-4588
Published: 2025
Journal Articles

Long-term outcomes of syngeneic transplantation in multiple myeloma: Valuable legacy or obsolete option? a study from the chronic malignancies working party of the EBMT

Free
Iman Abou Dalle, Luuk Gras, Linda Koster, Hermann Einsele, Rodrigo Martino, Peter Pal Remenyi, Montserrat Rovira, Robert Zeiser, Francesca Bonifazi, Andreas Burchert, Jennifer Byrne, Yves Chalandon, Peter Dreger, Marija Elez, Martin Kaufmann, Francesca Kinsella, Stephan Mielke, Ioanna Sakellari, Jaime Sanz, Joanna Drozd-Sokolowska, Kavita Raj, Laurent Garderet, Meral Beksac, Ibrahim Yakoub-Agha, Patrick Hayden, Donal McLornan
Journal: Blood
Blood (2025) 146 (Supplement 1): 6357.
https://doi.org/10.1182/blood-2025-6357
Published: 2025