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Journal Articles

Plek2 as a novel downstream effector of p53: Targeting Plek2 ameliorates disease progression in p53-deficient myeloid malignancies

Free
Pan Wang, Xu Han, Honghao Bi, Ermin Li, Kehan Ren, Inci Aydemir, Wenjie Cai, Laya Soleimani, Peng Ji
Journal: Blood
Blood (2025) 146 (Supplement 1): 216.
https://doi.org/10.1182/blood-2025-216
Published: 2025
Journal Articles

Spatial transcriptomic dissection of the myeloproliferative neoplasm niche uncovers mutant clone interactions and microenvironmental rewiring

Free
Honghao Bi, Pan Wang, Ching Man Wai, Kehan Ren, Xu Han, Ermin Li, Laya Soleimani, Inci Aydemir, Wenjie Cai, Johanna Melo-Cardenas, Peng Ji
Journal: Blood
Blood (2025) 146 (Supplement 1): 3761.
https://doi.org/10.1182/blood-2025-3761
Published: 2025
Journal Articles

DHODH-driven pyrimidine metabolism is a targetable vulnerability in myeloproliferative neoplasms

Free
Pan Wang, Xu Han, Inci Aydemir, Ermin Li, Honghao Bi, Kehan Ren, Wenjie Cai, Laya Soleimani, Peng Ji
Journal: Blood
Blood (2025) 146 (Supplement 1): 69.
https://doi.org/10.1182/blood-2025-69
Published: 2025
Journal Articles

Protein Tyrosine Phosphatase PRL2 Promotes MLL -Rearranged Acute Myeloid Leukemia Development through Inhibiting the p53 Pathway

Free
Shiyu Xiao, Hongxia Chen, Michihiro Kobayashi, Yunpeng Bai, Sergio Barajas, Wenjie Cai, Zhong-Yin Zhang, Yan Liu
Journal: Blood
Blood (2024) 144 (Supplement 1): 4109.
https://doi.org/10.1182/blood-2024-198244
Published: 2024
Journal Articles

Polycom Group Protein Mel18 Inhibits Hematopoietic Stem Cell Self-Renewal through Repressing the Expression of Genes Important for Cellular Senescence and Proliferation

Free
Wenjie Cai, Sisi Chen, Xicheng Liu, Xintong Chen, Sergio Barajas, Shiyu Xiao, Hongxia Chen, Rongwen Xi, Zhonghua Gao, Feng Yue, Yan Liu
Journal: Blood
Blood (2023) 142 (Supplement 1): 1310.
https://doi.org/10.1182/blood-2023-180201
Published: 2023
Journal Articles

Mutant p53 Drives the Development of Myelodysplastic Syndromes Via Dysregulating Pre-mRNA Splicing in Hematopoietic Stem and Progenitor Cells

Free
Sergio Barajas, Sisi Chen, Sasidhar Vemula, Yuxia Yang, Edward Simpson, Wenjie Cai, Shiyu Xiao, Hongxia Chen, Stephanie Halene, Madina Sukhanova, Yunlong Liu, Omar Abdel-Wahab, Yan Liu
Journal: Blood
Blood (2023) 142 (Supplement 1): 4582.
https://doi.org/10.1182/blood-2023-180382
Published: 2023
Journal Articles

PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371

Free
Hongxia Chen, Yunpeng Bai, Michihiro Kobayashi, Shiyu Xiao, Wenjie Cai, Sergio Barajas, Sisi Chen, Jinmin Miao, Frederick Nguele Meke, Sasidhar Vemula, James P. Ropa, James M. Croop, H. Scott Boswell, Jun Wan, Yuzhi Jia, Huiping Liu, Loretta S. Li, Jessica K. Altman, Elizabeth A. Eklund, Peng Ji, Wei Tong, Hamid Band, Danny T. Huang, Leonidas C. Platanias, Zhong-Yin Zhang, Yan Liu
Journal: Blood
Blood (2023) 141 (3): 244–259.
https://doi.org/10.1182/blood.2022016580
Published: 2023
Includes: Supplemental data
Journal Articles

Chronic Inflammation Drives p53 Mutant Clonal Hematopoiesis Via Activating the NLRP1 Inflammasome

Free
Sergio of Barajas, Sasidhar Vemula, Sisi Chen, Hongxia Chen, Wenjie Cai, Shiyu Xiao, Stephanie Halene, Omar Abdel-Wahab, Linsey Mayo, Sharon A. Savage, Yan Liu
Journal: Blood
Blood (2022) 140 (Supplement 1): 5743–5744.
https://doi.org/10.1182/blood-2022-169754
Published: 2022