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Wendy Beguelin
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Journal Articles

EZH2 oncogenic mutation disrupts germinal center B cell dynamics and promotes early lymphomagenic behaviors

Free
Kibaek Choe, Chanhong Min, Ioannis Karagiannidis, Nikita Sivakumar, Chris Xu, Ari Melnick, Jude Phillip, Wendy Béguelin
Journal: Blood
Blood (2025) 146 (Supplement 1): 1479.
https://doi.org/10.1182/blood-2025-1479
Published: 2025
Journal Articles

A phase 1b trial of the EZH2 inhibitor tazemetostat combined with CAR T cell therapy in B cell lymphomas

Free
Samuel Yamshon, Caitlin Gribbin, Yusuke Isshiki, Ioannis Karagiannidis, Sunjae Lee, Jizhi Yan, Gwynne Ozkan, Anna Alperovich, Barbara Ma, Christopher Hackett, Mateo Mejia-Saldarriaga, Daniel Choi, Selina Chen-Kiang, John Leonard, Ari Melnick, Juliet Barker, Giorgio Inghirami, Wendy Béguelin, Peter Martin
Journal: Blood
Blood (2025) 146 (Supplement 1): 1011.
https://doi.org/10.1182/blood-2025-1011
Published: 2025
Journal Articles

Spen loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and TLR pathway therapeutic vulnerabilities

Free
Benedikt Pelzer, Cem Meydan, Isaac Spiegel, Ioannis Karagiannidis, Min Xia, Matthew Teater, Emma Welter, Zowie Searcy, Laura Hilton, Darko Barisic, Pengyan Fa, Shenon Sethi, Irem Isgor, Jessie Fielding, Alireza Karbalyhareh, Colin Burdette, Sravya Tumuluru, Sonia Debek, Sunjae Lee, Ramon Massoni-Badosa, Ceyda Durmaz, Eralda Salataj, Prasath Pararajalingam, Zhengming Chen, Richard Pelzl, Sanket Shah, Martin Rivas, Kenneth Hoehn, Coraline Mlynarczyk, Hannah Isles, Ahmet Dogan, Kojo Elenitoba-Johnson, David Scott, Kostiantyn Dreval, Ryan Morin, Christina Leslie, Rishi Puri, Jacob Geri, Christopher Chin, Amy Chadburn, Christopher Mason, Hans Christian Reinhardt, Montserrat Anguera, Wendy Béguelin, Leandro Venturutti, Ari Melnick
Journal: Blood
Blood (2025) 146 (Supplement 1): 140.
https://doi.org/10.1182/blood-2025-140
Published: 2025
Journal Articles

Sasp-driven immune evasion defines a novel African ancestry-associated DLBCL subtype with distinctive molecular and immune vulnerabilities

Free
Sanket Shah, Meng Li, Michelle Lee, Matthew Teater, Kumudha Balakrishnan, Vishal Sahu, Vignesh Shanmugam, Sunjae Lee, Isabella Kong, Ioannis Karagiannidis, Tania Sainz, Wilfred Leung, Andrea Orlando, Jongkuen Lee, Benedikt Pelzer, Dejauwne Young, Sravya Tumuluru, David Jaye, Mohamed Moustafa, Deniz Peker, Yusuke Isshiki, Daniela Magliulo, Hao Shen, Piali Mukherjee, Anthony Santella, Maneeza Bilal, Pengyan Fa, Lisa Roth, Giorgio Inghirami, Victoria Alagiozian-Angelova, Leandro Cerchietti, Simone Sidoli, Paul Rubinstein, Roberta Zappasodi, Wendy Béguelin, Yuri Fedoriw, Francisco Vega, Jean Koff, Christopher Flowers, Ari Melnick
Journal: Blood
Blood (2025) 146 (Supplement 1): 3.
https://doi.org/10.1182/blood-2025-3
Published: 2025
Journal Articles

Biology as vulnerability in follicular lymphoma: genetics, epigenetics, and immunogenetics

Available to Purchase
Ferran Araujo-Ayala, Wendy Béguelin
Journal: Blood
Blood (2025) 146 (15): 1759–1769.
https://doi.org/10.1182/blood.2024026020
Published: 2025
Journal Articles

Synergistic antitumor effect of combined EZH2 and DOT1L inhibition in B-cell lymphoma

Available to Purchase
Van Thuy Mai Nguyen, Hiroe Namba, Hayley Porter, Daria Shlyueva, Ernesto Lopez, Alan Melcher, Wendy Béguelin, Ari M. Melnick, Kristian Helin
Journal: Blood
Blood (2025) 145 (24): 2873–2886.
https://doi.org/10.1182/blood.2024026534
Published: 2025
Includes: Supplemental data
Journal Articles

Follicular Dendritic Cells Represent a Therapeutic Vulnerability in Early Follicular Lymphoma

Free
Caitlin Gribbin, Dylan McNally, Ioannis Karagiannidis, Henna S. Nam, Hiranmayi Ravichandran, Baptiste Brauge, Karin Tarte, Amy Chadburn, Madhu M Ouseph, Sebastian Carrasco, Christian Steidl, David W. Scott, Ari M Melnick, Wendy Béguelin
Journal: Blood
Blood (2024) 144 (Supplement 1): 739.
https://doi.org/10.1182/blood-2024-198542
Published: 2024
Journal Articles

DTX1 Controls Germinal Center B-Cell Development and Lymphomagenesis

Free
Atish Kizhakeyil, Sreejoyee Ghosh, Estela Rojas-Neira, Qing Deng, Jared Henderson, Jordan Showell, Ari Melnick, Wendy Beguelin, Francisco Vega, Loretta J. Nastoupil, Michael R Green
Journal: Blood
Blood (2022) 140 (Supplement 1): 1700–1701.
https://doi.org/10.1182/blood-2022-167086
Published: 2022
Journal Articles

Evolution of the Tumor Microenvironment throughout Progression and Transformation of EZH2 Mutant Follicular Lymphoma

Free
Yusuke Isshiki, Dylan McNally, Ari M. Melnick, Wendy Béguelin
Journal: Blood
Blood (2021) 138 (Supplement 1): 446.
https://doi.org/10.1182/blood-2021-148996
Published: 2021
Journal Articles

Aging-Associated Epigenetic Reprogramming Alters the Germinal Center Reaction and Targets Pathways Related to Lymphomagenesis

Free
Rossella Marullo, Maria Victoria Revuelta, Wendy Béguelin, Juan Lara-Garcia, Leandro Cerchietti
Journal: Blood
Blood (2021) 138 (Supplement 1): 676.
https://doi.org/10.1182/blood-2021-152684
Published: 2021
Journal Articles

The Tumor Associated Antigen PRAME Exhibits Dualistic Functions That Are Targetable in Diffuse Large B-Cell Lymphoma

Free
Katsuyoshi Takata, MD PhD, Lauren C. Chong, MSc, Daisuke Ennishi, MD PhD, Avinash Thakur, PhD, Shannon Healy, PhD, Elena Viganò, PhD, Tao Dao, MD PhD, Julie S Nielsen, Susana Ben-Neriah, BSc, Tomohiro Aoki, MD PhD, Ethan Tse, Stacy Hung, Michael Y. Li, BS, Merrill Boyle, BSc, Sung Soo Mun, Christopher Bourne, Bruce W Woolcock, Adele Telenius, Allen Zhang, Ali Bashashati, Saeed Saberi, Gianluca D' Antonio, Brad H Nelson, Sohrab P Shah, Pamela Hoodless, Ari Melnick, MD, Randy D. Gascoyne, MD, Joseph M Connors, MD, David A. Scheinberg, MD PhD, Wendy Béguelin, PhD, David W. Scott, MBChB, PhD, Christian Steidl, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34.
https://doi.org/10.1182/blood-2020-141168
Published: 2020
Journal Articles

EZH2 Gain-of-Function Mutations Generate a Lymphoma-Permissive Immune Niche

Free
Wendy Béguelin, PhD, Matthew R Teater, PhD, Cem Meydan, PhD, Jude M Phillip, PhD, Ari Melnick, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2768.
https://doi.org/10.1182/blood-2019-132263
Published: 2019
Journal Articles

Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 As a Therapeutic Target for Restoring MHC Expression in Diffuse Large B-Cell Lymphoma

Free
Daisuke Ennishi, MDPhD, Katsuyoshi Takata, MD PhD, Wendy Béguelin, PhD, Gerben Duns, PhD, Anja Mottok, Pedro Farinha, MD PhD, Ali Bashashati, David Scott, Merrill Boyle, BSc, Barbara Meissner, PhD, Susana Ben-Neriah, BSc, Bruce W Woolcock, Adele Telenius, Daniel Lai, Matthew R Teater, PhD, Robert Kridel, PhD MD, Kerry J Savage, BSc, MD MSc, Laurie H Sehn, MD MPH, Ryan D. Morin, PhD BSc MSc, Marco A. Marra, PhD, Sohrab P Shah, Joseph M. Connors, MD, Randy D. Gascoyne, MD, David W. Scott, PhD MD FRACP FRCPA, Ari M Melnick, MD, Christian Steidl, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1560.
https://doi.org/10.1182/blood-2018-99-112010
Published: 2018
Journal Articles

EZH2 Enables the Proliferation of Germinal Center B Cells and DLBCL through a Rb-E2F1 Positive Feedback Loop Involving Repression of CDKN1A

Free
Wendy Béguelin, PhD, Martin A Rivas, PhD, María Teresa Calvo Fernández, Ari Melnick, MD
Journal: Blood
Blood (2016) 128 (22): 734.
https://doi.org/10.1182/blood.V128.22.734.734
Published: 2016
Journal Articles

A Chromatin Reader That Acts As a Key to Lock in and Coordinate Recruitment of Transcription Factors and a Novel Polycomb Complex to Bivalent Chromatin Thus Driving Formation of Germinal Centers and B-Cell Lymphomas

Free
Wendy Béguelin, Matt Teater, Connie Corcoran, Michelle Hamline, Randy D. Gascoyne, Ross L. Levine, MD, Omar Abdel-Wahab, Rita Shaknovich, Olivier Elemento, Vivian J. Bardwell, Ari Melnick, MD
Journal: Blood
Blood (2015) 126 (23): 434.
https://doi.org/10.1182/blood.V126.23.434.434
Published: 2015
Journal Articles

BAP1 Loss Results in EZH2-Dependent Transformation in Myelodysplastic Syndromes

Free
Lindsay M LaFave, PhD, Wendy Béguelin, PhD, Richard Koche, PhD, Matt Teater, Efthymia Papalexi, Barbara Spitzer, MD, Sarah Knutson, PhD, John Campbell, PhD, Heike Keilhack, PhD, Paul M Thomas, PhD, Neil L Kelleher, PhD, Omar Abdel-Wahab, Ari M. Melnick, MD, Scott A. Armstrong, MD PhD, Ross L. Levine, MD
Journal: Blood
Blood (2015) 126 (23): 713.
https://doi.org/10.1182/blood.V126.23.713.713
Published: 2015
Journal Articles

EZH2 and BCL6 Cooperate To Create The Germinal Center B-Cell Phenotype and Induce Lymphomas Through Formation and Repression Of Bivalent Chromatin Domains

Free
Wendy Béguelin, PhD, Matt R. Teater, MS, Katerina Hatzi, PhD, Relja Popovich, PhD, Yanwen Jiang, PhD, Karen L. Bunting, PhD, Monica Rosen, Hao Shen, MD, Shao Ning Yang, Young Rock Chung, MSc, Rita Shaknovich, MD/PhD, Caretha Creasy, Randy D. Gascoyne, MD, Leandro Cerchietti, MD, Ross L. Levine, MD, Omar Abdel-Wahab, MD, Jonathan D. Licht, MD, Olivier Elemento, PhD, Ari M. Melnick, MD
Journal: Blood
Blood (2013) 122 (21): 1.
https://doi.org/10.1182/blood.V122.21.1.1
Published: 2013
Journal Articles

IL10 Receptor a Is a Novel Therapeutic Target That Is Epigenetically Disregulated in Low Grade Lymphomas with Plasmacytic Differentiation.

Free
Wendy Beguelin, Ph.D., Alisa Chalmers, Lucas Tsikitas, Wayne Tam, MD, PhD, Govind Bhagat, MD, Rita Shaknovich, MD/PhD
Journal: Blood
Blood (2012) 120 (21): 2383.
https://doi.org/10.1182/blood.V120.21.2383.2383
Published: 2012