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Shizuka Yamano
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Journal Articles

Functional genomics studies identify determinants of response vs. resistance to pharmacological inhibitors of KRAS in multiple myeloma

Free
Torsten Steinbrunn, Arnold Bolomsky, Ryosuke Shirasaki, Omar Al-Odat, Olga Dashevsky, Huihui Tang, Shizuka Yamano, Oliver Bohorquez, Brian Glassner, Eleni Anastasakou, Vikas Gupta, Jonathan Licht, Benjamin Barwick, Lawrence Boise, Ricardo De Matos Simoes, James Christensen, Ryan Young, Constantine Mitsiades
Journal: Blood
Blood (2025) 146 (Supplement 1): 327.
https://doi.org/10.1182/blood-2025-327
Published: 2025
Journal Articles

Identification of novel “driver” genes of multiple myeloma through genome-scale CRISPR activation studies

Free
Huihui Tang, Ricardo De Matos Simoes, Torsten Steinbrunn, Ryosuke Shirasaki, Olga Dashevsky, Eleni Anastasakou, Oliver Bohorquez, Shizuka Yamano, Evangelos Papadopoulos, Lisa Leypoldt, Arun Wiita, Olwyn Mahon, Vikas Gupta, Jonathan Licht, Benjamin Barwick, Lawrence Boise, Constantine Mitsiades
Journal: Blood
Blood (2025) 146 (Supplement 1): 2173.
https://doi.org/10.1182/blood-2025-2173
Published: 2025
Journal Articles

Negative regulators of survival and proliferation (NRSPs) identified by CRISPR activation studies in multiple myeloma (MM) vs. other neoplasias: Therapeutic implications

Free
Olga Dashevsky, Ricardo De Matos Simoes, Huihui Tang, Torsten Steinbrunn, Shizuka Yamano, Eleni Anastasakou, Benjamin Barwick, Sara Gandolfi, Ryosuke Shirasaki, Vikas Gupta, Michal Sheffer, Jonathan Licht, Lawrence Boise, Matthew Oser, Constantine Mitsiades
Journal: Blood
Blood (2025) 146 (Supplement 1): 688.
https://doi.org/10.1182/blood-2025-688
Published: 2025
Journal Articles

Functional Genomics Studies Decipher the Genetic Perturbations and Unravel Mechanisms of Response/Resistance upon Mutant-Specific KRAS Inhibition in Multiple Myeloma

Free
Torsten Steinbrunn, Ryosuke Shirasaki, Olga Dashevsky, Huihui Tang, Shizuka Yamano, Phaik Ju Teoh, Lisa Leypoldt, Brian Glassner, Ricardo De Matos Simoes, James Christensen, Constantine S Mitsiades
Journal: Blood
Blood (2024) 144 (Supplement 1): 3286.
https://doi.org/10.1182/blood-2024-211598
Published: 2024
Journal Articles

Targeting Mutant KRAS with Novel Mutant-Specific Pharmacological Inhibitors: Activity Against Myeloma and Other Lymphoid Malignant Cells and Molecular Mechanisms of Resistance

Free
Torsten Steinbrunn, Ryosuke Shirasaki, Olga Dashevsky, Huihui Tang, Shizuka Yamano, Rin Mizuno, Takeru Sugihara, Phaik Ju Teoh, Lisa B Leypoldt, Mariko Kaji, Jeffrey Sorrell, Brian J Glassner, Ricardo De Matos Simoes, James Christensen, Constantine S Mitsiades
Journal: Blood
Blood (2023) 142 (Supplement 1): 4186.
https://doi.org/10.1182/blood-2023-182476
Published: 2023
Journal Articles

Single-Cell Functional Genomics of Natural Killer Cell Interaction with Blood Cancers

Free
Olli Dufva, Sara Gandolfi, Jani Huuhtanen, Olga Dashevsky, Khalid Saeed, Jay Klievink, Petra Johanna Nygren, Jonas Bouhlal, Jenni Lahtela, Anna Näätänen, Bishwa Ghimire, Tiina Hannunen, Pekka Ellonen, Hanna Duàn, Jason Theodoropoulos, Essi Laajala, Aino Häkkinen, Jouni Härkönen, Petri Pölönen, Merja Heinäniemi, Shizuka Yamano, Ryosuke Shirasaki, David Barbie, Jennifer A. Roth, Rizwan Romee, Michal Sheffer, Harri Lähdesmäki, Dean Anthony Lee, Ricardo De Matos Simoes, Matti Kankainen, Constantine S. Mitsiades, Satu Mustjoki
Journal: Blood
Blood (2022) 140 (Supplement 1): 8343–8344.
https://doi.org/10.1182/blood-2022-167535
Published: 2022
Journal Articles

Systematic Functional Characterization for Loss of Function Events Cooperating with TP53 Loss in High-Risk 17p13(del) Multiple Myeloma

Free
Phaik Ju Teoh, Ricardo De Matos Simoes, Tae-Hoon Chung, Mick Lee, Olga Dashevsky, Shizuka Yamano, Roger Foo, Wee Joo Chng, Constantine S. Mitsiades
Journal: Blood
Blood (2022) 140 (Supplement 1): 7110–7111.
https://doi.org/10.1182/blood-2022-159316
Published: 2022
Journal Articles

Functional Genomic Characterization of Endoplasmic Reticulum-Associated Dependencies in Multiple Myeloma - Biologic and Therapeutic Implications

Free
Ryosuke Shirasaki, MD PhD, Ricardo De Matos Simoes, PhD, Shizuka Yamano, Sondra L. Downey-Kopyscinski, PhD, Brian Glassner, PhD, Huihui Tang, PhD, Vikas Gupta, MD PhD, Aviad Tsherniak, PhD, Francisca Vazquez, PhD, Jonathan D. Licht, MD, Larry H. Boise, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
https://doi.org/10.1182/blood-2020-143117
Published: 2020
Journal Articles

Mechanisms Regulating Myeloma Cell Responsiveness to Antisense Oligonucleotides Targeting IRF4

Free
Ryosuke Shirasaki, MD PhD, Esperanza M Algarín, PhD, Ricardo De Matos Simoes, PhD, Sondra L. Downey-Kopyscinski, PhD, Shizuka Yamano, Xiaolin Luo, Youngsoo Kim, PhD, Robert MacLeod, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32.
https://doi.org/10.1182/blood-2020-142518
Published: 2020
Journal Articles

POU2AF1 As a Master Regulator of Oncogenic Transcription Factor Networks in Myeloma

Free
Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD, Huihui Tang, PhD, Shizuka Yamano, Benjamin G Barwick, PhD, Sara Gandolfi, MD, Eugen Dhimolea, PhD, Sondra L. Downey-Kopyscinski, PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Michal Sheffer, PhD, Dhvanir Kansara, Megan Bariteau, BSc, Jeffrey Sorrell, BA, Vikas Gupta, MD PhD, Aedin Culhane, PhD, Aviad Tsherniak, PhD, Francisca Vazquez, PhD, Larry H. Boise, PhD, Jonathan D. Licht, MD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–19.
https://doi.org/10.1182/blood-2020-142580
Published: 2020