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James Christensen
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Journal Articles

Functional genomics studies identify determinants of response vs. resistance to pharmacological inhibitors of KRAS in multiple myeloma

Free
Torsten Steinbrunn, Arnold Bolomsky, Ryosuke Shirasaki, Omar Al-Odat, Olga Dashevsky, Huihui Tang, Shizuka Yamano, Oliver Bohorquez, Brian Glassner, Eleni Anastasakou, Vikas Gupta, Jonathan Licht, Benjamin Barwick, Lawrence Boise, Ricardo De Matos Simoes, James Christensen, Ryan Young, Constantine Mitsiades
Journal: Blood
Blood (2025) 146 (Supplement 1): 327.
https://doi.org/10.1182/blood-2025-327
Published: 2025
Journal Articles

Functional Genomics Studies Decipher the Genetic Perturbations and Unravel Mechanisms of Response/Resistance upon Mutant-Specific KRAS Inhibition in Multiple Myeloma

Free
Torsten Steinbrunn, Ryosuke Shirasaki, Olga Dashevsky, Huihui Tang, Shizuka Yamano, Phaik Ju Teoh, Lisa Leypoldt, Brian Glassner, Ricardo De Matos Simoes, James Christensen, Constantine S Mitsiades
Journal: Blood
Blood (2024) 144 (Supplement 1): 3286.
https://doi.org/10.1182/blood-2024-211598
Published: 2024
Journal Articles

Targeting Mutant KRAS with Novel Mutant-Specific Pharmacological Inhibitors: Activity Against Myeloma and Other Lymphoid Malignant Cells and Molecular Mechanisms of Resistance

Free
Torsten Steinbrunn, Ryosuke Shirasaki, Olga Dashevsky, Huihui Tang, Shizuka Yamano, Rin Mizuno, Takeru Sugihara, Phaik Ju Teoh, Lisa B Leypoldt, Mariko Kaji, Jeffrey Sorrell, Brian J Glassner, Ricardo De Matos Simoes, James Christensen, Constantine S Mitsiades
Journal: Blood
Blood (2023) 142 (Supplement 1): 4186.
https://doi.org/10.1182/blood-2023-182476
Published: 2023
Journal Articles

Combined Targeting of the MET and FGF Receptor Tyrosine Kinases Induces Sustained AML Cell Death by Preventing Compensatory Upregulation of HGF in Response to MET Kinase Inhibition

Free
Alex Kentsis, MD, PhD, Takaomi Sanda, MD, PhD, Casie Reed, BS, Scott J. Rodig, MD, PhD, Eleni Tholouli, PhD, MRCPath, Vu Ngo, PhD, Jeffery Lorne Kutok, MD, PhD, Suzanne E. Dahlberg, PhD, Lisa A Moreau, PhD, George Vande Woude, PhD, James Christensen, MD, Richard Byers, PhD, MBChB, FRCPath, Andrew L. Kung, MD, PhD, Louis M. Staudt, MD., Ph.D., Thomas Look, MD
Journal: Blood
Blood (2011) 118 (21): 1405.
https://doi.org/10.1182/blood.V118.21.1405.1405
Published: 2011
Journal Articles

Enhanced c-Met activity promotes G-CSF–induced mobilization of hematopoietic progenitor cells via ROS signaling

Free
Melania Tesio, Karin Golan, Simona Corso, Silvia Giordano, Amir Schajnovitz, Yaron Vagima, Shoham Shivtiel, Alexander Kalinkovich, Luisa Caione, Loretta Gammaitoni, Elisa Laurenti, Eike C. Buss, Elias Shezen, Tomer Itkin, Orit Kollet, Isabelle Petit, Andreas Trumpp, James Christensen, Massimo Aglietta, Wanda Piacibello, Tsvee Lapidot
Journal: Blood
Blood (2011) 117 (2): 419–428.
https://doi.org/10.1182/blood-2009-06-230359
Published: 2011
Includes: Supplemental data