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John Goulding
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Journal Articles

The development of FT839: An off-the-shelf CD19xCD38 dual-CAR T cell for the treatment of multiple myeloma

Free
Spas Markov, John Reiser, Brian Groff, Shilpi Chandra, Soheila Shirinbak, Carissa Dege, Bryan Hancock, Dan Lu, Alma Gutierrez, Angela Gentile, Tom Lee, Ramzey Abujarour, Betsy Rezner, John Goulding, Karl-Johan Malmberg, Maksim Mamonkin, Bahram Valamehr, Jode Goodridge, Martin Hosking, Alex Garcia
Journal: Blood
Blood (2025) 146 (Supplement 1): 7631.
https://doi.org/10.1182/blood-2025-7631
Published: 2025
Journal Articles

Targeting of tumor antigen CD38 and stress antigens MICA/B by CAR T cells provides a unique approach for the comprehensive treatment of multiple myeloma

Free
Soheila Shirinbak, Shilpi Chandra, Brian Groff, Samad Ibitokou, Spas Markov, John Reiser, Bryan Hancock, Tom Daily, Alma Gutierrez, Miguel Meza, Tom Lee, Betsy Rezner, Ramzey Abujarour, Raedun Clarke, John Goulding, Karl-Johan Malmberg, Maksim Mamonkin, Kai Wucherpfennig, Bahram Valamehr, Jode Goodridge, Alex Garcia, Martin Hosking
Journal: Blood
Blood (2025) 146 (Supplement 1): 2350.
https://doi.org/10.1182/blood-2025-2350
Published: 2025
Journal Articles

Development of next generation multi-antigen targeting off-the-shelf CAR T cells for conditioning-free treatment of B-cell lymphoma

Free
Shilpi Chandra, John Reiser, Brian Groff, Carissa Dege, Bryan Hancock, Alison O'Connor, Alma Gutierrez, Angela Gentile, Tom Lee, Ramzey Abujarour, Raedun Clarke, Betsy Rezner, John Goulding, Jode Goodridge, Karl-Johan Malmberg, Maksim Mamonkin, Bahram Valamehr, Alex Garcia, Martin Hosking
Journal: Blood
Blood (2025) 146 (Supplement 1): 4121.
https://doi.org/10.1182/blood-2025-4121
Published: 2025
Journal Articles

The development of an off-the-shelf CAR T-cell therapy co-targeting CD19 and CD38 for broad application in autoimmune disease

Free
Mark Jelcic, Daniel Morales-Mantilla, John Reiser, Brian Groff, Alma Gutierrez, Rina Ngalame, Alan Williams, Carissa Dege, Shilpi Chandra, Spas Markov, Soheila Shirinbak, Bjoern Gaertner, Mochtar Pribadi, Karina Palomares, Loraine Campanati, Amanda Yzaguirre, Stephanie Kennedy, Angela Macia, Alison O'Connor, Bryan Hancock, Pei-Fang Tsai, Ramzey Abujarour, Tom Lee, Raedun Clarke, Karl-Johan Malmberg, Maksim Mamonkin, Bahram Valamehr, Vaneet Sandhu, Alex Garcia, Martin Hosking, John Goulding, Jode Goodridge
Journal: Blood
Blood (2025) 146 (Supplement 1): 5895.
https://doi.org/10.1182/blood-2025-5895
Published: 2025
Journal Articles

Alloimmune Defense Receptor Combined with Genetic Ablation of Adhesion Ligand CD58 Is a Comprehensive Approach to Promote Functional Persistence of Allogeneic Cell Therapies without Conditioning Chemotherapy

Free
Alan Williams, Rina Mbofung, Daniel Morales-Mantilla, Brian Groff, Alison O'Connor, Binzhong Li, Ramesh Janani, Betsy Rezner, Mark Jelcic, Yijia Pan, Tom Lee, Karl-Johan Malmberg, Maksim Mamonkin, John Goulding, Jode Goodridge, Bahram Valamehr
Journal: Blood
Blood (2024) 144 (Supplement 1): 503.
https://doi.org/10.1182/blood-2024-210846
Published: 2024
Journal Articles

Next-Generation Off-the-Shelf CAR T-Cell Therapy Developed to Eliminate a Broad Spectrum of Pathogenic Cells in Hematological Diseases in the Absence of Conditioning Chemotherapy

Free
John Goulding, Mark Jelcic, Daniel Morales-Mantilla, John Reiser, Alison O'Connor, Rina Mbofung, Alan Williams, Dan Lu, Bi-Huei Yang, Alma Gutierrez, Miguel Meza, Yijia Pan, Jonatan Tuncel, Bryan Hancock, Sean Sherman, Alec Witty, Eigen Peralta, Martin Hosking, Lilly Wong, Tom Lee, Jode Goodridge, Bahram Valamehr
Journal: Blood
Blood (2024) 144 (Supplement 1): 4801.
https://doi.org/10.1182/blood-2024-209465
Published: 2024
Journal Articles

Development of Induced Pluripotent Stem Cell-Derived T Cells Exhibiting Phenotypic and Functional Attributes of Primary CAR T Cells

Free
Bryan Hancock, Jonatan Tuncel, Kyla Omilusik, Alison O'Connor, Bi-Huei Yang, Matthew Haynes, Amanda Yzaguirre, Karina Palomares, Sandeep Kothapally Hanok, Matthew Denholtz, Martin Hosking, Eigen Peralta, Tom Lee, Raedun Clarke, Sjoukje Van Der Stegen, John Goulding, Jode Goodridge, Michel Sadelain, Bahram Valamehr
Journal: Blood
Blood (2024) 144 (Supplement 1): 3474.
https://doi.org/10.1182/blood-2024-210786
Published: 2024
Journal Articles

A Novel Dual-Antigen Targeting Approach Enables Off-the-Shelf CAR NK Cells to Effectively Recognize and Eliminate the Heterogenous Population Associated with AML

Free
Zachary Davis, Frank Cichocki, Martin Felices, Hongbo Wang, Peter Hinderlie, Mark Juckett, Joseph Maakaron, Gregory I. Berk, Bryan Hancock, John Goulding, Ryan Bjordahl, Bahram Valamehr, Jeffrey S. Miller, MD
Journal: Blood
Blood (2022) 140 (Supplement 1): 10288–10289.
https://doi.org/10.1182/blood-2022-168981
Published: 2022
Journal Articles

Dual Chimeric Antigen Receptor Approach Combining Novel Tumor Targeting Strategies Circumvents Antigen Escape in Multiple Myeloma

Free
John Reiser, Ketan Mathavan, Sajid Mahmood, Yijia Pan, Bryan Hancock, Robert Blum, Wen-I Yeh, Andrew Houk, Chia-Wei Chang, Tom Lee, Uta Hopken, John Goulding, Armin Rehm, Kai W. Wucherpfennig, Jode P Goodridge, Ryan Bjordahl, Bahram Valamehr
Journal: Blood
Blood (2021) 138 (Supplement 1): 1718.
https://doi.org/10.1182/blood-2021-154025
Published: 2021
Journal Articles

Development of a Novel MICA/B-Specific CAR As a Pan-Tumor Targeting Strategy for Off-the-Shelf, Cell-Based Cancer Immunotherapy

Free
Ryan Bjordahl, PhD, John Goulding, PhD, Mochtar Pribadi, PhD, Robert Blum, MS, Chiawei Chang, Yijia Pan, PhD, Lucas Ferrari de Andrade, PhD, Kai W. Wucherpfennig, Yu-Waye Chu, MD, Hui-yi Chu, PhD, Wen-I Yeh, PhD, Svetlana Gaidarova, MS, Ellen Liu, PhD, Shohreh Sikaroodi, PhD, Lauren Fong, PhD, Janel Huffman, MS, Tom Lee, PhD, Bahram Valamehr, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-141095
Published: 2020