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Journal Articles

Targets of BTK and IRAK4 pathways in cns lymphoma: Identification of CXCL10 as a prognostic biomarker in CSF and its receptor, CXCR3, as a mediator of pro-survival signaling

Ming Lu, Huimin Geng, Lingjing Chen, Lisa Drew, Andrew Bloecher, Courtney Andersen, Aylin Saleh, Pasha Fooman, Clifford Lowell, James Rubenstein

Blood (2025) 146 (Supplement 1): 5321.

https://doi.org/10.1182/blood-2025-5321

Published: 2025

Journal Articles

Targeted hyperactivation of oncogenic STAT5-signaling in acute lymphoblastic leukemia

Kohei Kume, Zhangliang Cheng, Jian Xin Lin, Liang Xu, Gang Xiao, Mark Robinson, Etienne Leveille, Eden Bramson, Kadriye Nehir Cosgun, Huimin Geng, Merja Heinäniemi, Thomas Graeber, Janis Abkowitz, Hongbo Chi, Warren Alexander, Roberto Chiarle, Warren Leonard, Markus Müschen

Blood (2025) 146 (Supplement 1): 433.

https://doi.org/10.1182/blood-2025-433

Published: 2025

Journal Articles

Lipid uptake via FATP2 enhances CAR-t therapy resistance in B-cell acute lymphoblastic leukemia

Blood (2025) 146 (Supplement 1): 325.

https://doi.org/10.1182/blood-2025-325

Published: 2025

Journal Articles

Integrative genomic, single-cell, and functional profiling uncovers immune consequences of the CD48–CD244 axis in NK cells in multiple myeloma

Bonell Patino-Escobar, Torsten Steinbrunn, Lucy Perez-Lugo, Sham Rampersaud, Huimin Geng, Fernando Salangsang, Paul Phojanakong, Juan Camara-Serrano, Yan Zeng, Veronica Steri, Oscar Aguilar, Constantine Mitsiades, Arun Wiita

Blood (2025) 146 (Supplement 1): 687.

https://doi.org/10.1182/blood-2025-687

Published: 2025

Journal Articles

Unbiased in-depth surfaceome profiling of Acute Myeloid Leukemia reveals novel immunotherapy targets beyond canonical membrane proteins

Blood (2025) 146 (Supplement 1): 385.

https://doi.org/10.1182/blood-2025-385

Published: 2025

Journal Articles

Tumor-induced dendritic cell dysfunction impairs T-cell proliferation and confers poor prognosis in high-risk acute lymphoblastic leukemia

Blood (2025) 146 (Supplement 1): 5138.

https://doi.org/10.1182/blood-2025-5138

Published: 2025

Journal Articles

Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients

Alastair L. Smith, Nicholas Denny, Catherine Chahrour, Kim Sharp, Marta Arachi, Ana M. Dopico-Fernandez, Natalina Elliott, Joe R. Harman, Thomas Jackson, Huimin Geng, Owen Smith, Jonathan Bond, Irene Roberts, Ronald W. Stam, Nicholas T. Crump, James O. J. Davies, Anindita Roy, Thomas A. Milne

Blood (2025) 146 (17): 2073–2087.

https://doi.org/10.1182/blood.2024028019

Published: 2025

Includes: Supplemental data

Journal Articles

Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR T cells

Blood (2025) 146 (7): 819–833.

https://doi.org/10.1182/blood.2024025536

Published: 2025

Includes: Supplemental data

Journal Articles

Toll-like Receptor 7/8 Pathway Is a Therapeutic Target in Primary CNS Lymphoma

Michael P Randall, Huimin Geng, Lingjing Chen, Aishwarya Ballapuram, Chitoh Yung, Ming Lu, Gregory Chin, Michael Mish, Jamie Bates, James L. Rubenstein

Blood (2024) 144 (Supplement 1): 978.

https://doi.org/10.1182/blood-2024-212194

Published: 2024

Journal Articles

Inhibiting Free Fatty Acid Transport to Improve CAR-T Cell Therapy of Relapsed B-Cell Acute Lymphoblastic Leukemia

Clarissa Garcia, Kaylyn Lyons, Tian Liu, Ilaria Iacobucci, Amanda Novak, Amy Argabright, Alexis Donnelly, Julian Grandvallet Contreras, Huimin Geng, Sabrina Smith, Xin Zhou, Markus Müschen, John Edgar Dick, Julie R Haines, Angelo D'Alessandro, Charles G. Mullighan, Tzu Phang, M. Eric Kohler, Matthew Witkowski

Blood (2024) 144 (Supplement 1): 1446.

https://doi.org/10.1182/blood-2024-201015

Published: 2024

Journal Articles

BTK Degradation As a Novel Therapeutic Strategy in Relapsed CNS Lymphoma: Proof of Concept Studies in Intracranial Patient-Derived, Rodent Models

Jun Ma, Michael P Randall, Ming Lu, Lingjing Chen, Huimin Geng, Aishwarya Kumar, Saloni Malla, Mark Noviski, Ryan Rountree, James L. Rubenstein

Blood (2024) 144 (Supplement 1): 2988.

https://doi.org/10.1182/blood-2024-211266

Published: 2024

Journal Articles

CD48: Friend or Foe in NK-Cell Immunosurveillance of Multiple Myeloma?

Bonell Patiño-Escobar, Lucy Perez-Lugo, Huimin Geng, Fernando Salangsang, Paul Phojanakong, Juan Antonio Camara Serrano, Veronica Steri, Oscar A Aguilar, Arun P Wiita

Blood (2024) 144 (Supplement 1): 4646.

https://doi.org/10.1182/blood-2024-206465

Published: 2024

Journal Articles

Differential Gene Expression in KMT2A::AFF1 Leukemia Is Driven By Enhancer Heterogeneity

Alastair L Smith, Nicholas Denny, Catherine M Chahrour, Natalina Elliott, Thomas Jackson, Joe Harman, Huimin Geng, Irene Roberts, Nicholas Crump, James Oliver Davies, Anindita Roy, Thomas A Milne

Blood (2024) 144 (Supplement 1): 201.

https://doi.org/10.1182/blood-2024-208035

Published: 2024

Journal Articles

PKCδ-Mediated Phosphorylation of CD25 Initiates Feedback Control of Oncogenic Tyrosine Kinases in Acute Lymphoblastic Leukemia

Ruifeng Sun, Jaewoong Lee, Dewan Artadji, Mark E Robinson, Kohei Kume, Zhangliang Cheng, Kadriye Nehir Cosgun, Lai N Chan, Etienne Leveille, Ning Ma, Huimin Geng, Elisabeth Paietta, Nagarajan Vaidehi, Markus Müschen

Blood (2024) 144 (Supplement 1): 632.

https://doi.org/10.1182/blood-2024-211038

Published: 2024

Journal Articles

Targeting the SWI/SNF Chromatin Remodeling Complex Subunit SMARCA4 in ALL

Venkata Sesha Sai Abhinav Ayyadevara, Ashley Paik, Ria Perencsik, Monika Toma, Tomasz Skorski, Rozbeh Jafari, Gerald Wertheim, Huimin Geng, Christian Hurtz

Blood (2024) 144 (Supplement 1): 4216.

https://doi.org/10.1182/blood-2024-205936

Published: 2024

Journal Articles

KMT2A -Rearranged ALL Requires DYRK1A for Regulation of ERK Signaling and Cell Proliferation

Venkata Sesha Sai Abhinav Ayyadevara, Gerald Wertheim, John Chukinas, Joseph Loftus, Sung June Lee, Anil Kumar, Srividya Swaminathan, Rahul S Bhansali, Wayne Childers, Huimin Geng, Thomas A Milne, Xianxin Hua, Kathrin M. Bernt, Thierry Besson, Junwei Shi, John D. Crispino, Martin P Carroll, Sarah K. Tasian, Christian Hurtz

Blood (2024) 144 (Supplement 1): 1455.

https://doi.org/10.1182/blood-2024-206134

Published: 2024

Journal Articles

Trial in Progress: A Phase I/II Study of Tafasitamab Plus Lenalidomide in Patients with Relapsed CNS Lymphoma

Michael P Randall, Andreas Rauschecker, Liam Gima-Lange, Jenai Wilmoth, Lingjing Chen, Ming Lu, Huimin Geng, Haifaa Abdulhaq, James L. Rubenstein

Blood (2023) 142 (Supplement 1): 3104.

https://doi.org/10.1182/blood-2023-190698

Published: 2023

Journal Articles

Affinity Matured CD72 CAR-T Improves Efficacy Versus Low Antigen Density B-Cell Non-Hodgkin Lymphoma Models

Adila Izgutdina, William C Temple, Matthew Andrew Nix, Huimin Geng, Emilio Ramos, Akul Naik, Rebecca Larson, Fernando Salangsang, Paul Phojanakong, Juan Antonio Camara Serrano, Ons Zakraoui, Isa Tariq, Marcela V Maus, Veronica Steri, Arun P Wiita

Blood (2023) 142 (Supplement 1): 2068.

https://doi.org/10.1182/blood-2023-182873

Published: 2023

Journal Articles

Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma

Blood (2023) 142 (Supplement 1): 465.

https://doi.org/10.1182/blood-2023-182578

Published: 2023

Journal Articles

A Phosphatase Membrane-Shuttle Enables Feedback Control of B-Cell Signaling

Blood (2022) 140 (Supplement 1): 1698–1699.

https://doi.org/10.1182/blood-2022-170324

Published: 2022

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Targets of BTK and IRAK4 pathways in cns lymphoma: Identification of CXCL10 as a prognostic biomarker in CSF and its receptor, CXCR3, as a mediator of pro-survival signaling

Targeted hyperactivation of oncogenic STAT5-signaling in acute lymphoblastic leukemia

Lipid uptake via FATP2 enhances CAR-t therapy resistance in B-cell acute lymphoblastic leukemia

Integrative genomic, single-cell, and functional profiling uncovers immune consequences of the CD48–CD244 axis in NK cells in multiple myeloma

Unbiased in-depth surfaceome profiling of Acute Myeloid Leukemia reveals novel immunotherapy targets beyond canonical membrane proteins

Tumor-induced dendritic cell dysfunction impairs T-cell proliferation and confers poor prognosis in high-risk acute lymphoblastic leukemia

Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients

Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR T cells

Toll-like Receptor 7/8 Pathway Is a Therapeutic Target in Primary CNS Lymphoma

Inhibiting Free Fatty Acid Transport to Improve CAR-T Cell Therapy of Relapsed B-Cell Acute Lymphoblastic Leukemia

BTK Degradation As a Novel Therapeutic Strategy in Relapsed CNS Lymphoma: Proof of Concept Studies in Intracranial Patient-Derived, Rodent Models

CD48: Friend or Foe in NK-Cell Immunosurveillance of Multiple Myeloma?

Differential Gene Expression in KMT2A::AFF1 Leukemia Is Driven By Enhancer Heterogeneity

PKCδ-Mediated Phosphorylation of CD25 Initiates Feedback Control of Oncogenic Tyrosine Kinases in Acute Lymphoblastic Leukemia

Targeting the SWI/SNF Chromatin Remodeling Complex Subunit SMARCA4 in ALL

KMT2A -Rearranged ALL Requires DYRK1A for Regulation of ERK Signaling and Cell Proliferation

Trial in Progress: A Phase I/II Study of Tafasitamab Plus Lenalidomide in Patients with Relapsed CNS Lymphoma

Affinity Matured CD72 CAR-T Improves Efficacy Versus Low Antigen Density B-Cell Non-Hodgkin Lymphoma Models

Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma

A Phosphatase Membrane-Shuttle Enables Feedback Control of B-Cell Signaling

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