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Journal Articles

Sickling kinetics drive genotype-specific impairment of RBC deformability in sickle cell disease

Yuxuan Du, Zoe Sekyonda, Umut Gurkan

Blood (2025) 146 (Supplement 1): 4712.

https://doi.org/10.1182/blood-2025-4712

Published: 2025

Journal Articles

Acidosis and hypoxia cooperatively impair immune cell infiltration in a microengineered tumor microenvironment

Payam Fadaei, William Wulftange, Eamon Kraft, Kayla Klatt, Zoe Sekyonda, Reshmi Parameswaran, Umut Gurkan

Blood (2025) 146 (Supplement 1): 7629.

https://doi.org/10.1182/blood-2025-7629

Published: 2025

Journal Articles

Alpha-thalassemia and red blood cell heterogeneity in sickle cell trait: Interim findings from the achieving understanding of the natural history of sickle cell trait (AUNT) study

Rakhi Naik, Umut Gurkan, Mohan Madisetti, Zoe Sekyonda, Chiara Federic, Najibah Galadanci, Julie Kanter

Blood (2025) 146 (Supplement 1): 533.

https://doi.org/10.1182/blood-2025-533

Published: 2025

Journal Articles

Use of red cell deformability measurements to assess the impact of pyruvate kinase activators on combined drug and transfusion therapies

Abhinav Pasupuleti, Akshay Patwardhan, Ashwin Patel, Solomon Oshabaheebwa, Christopher Deliandes, Zoe Sekyonda, Erica Evans, Lindsey Abel, Michael Suster, Pedram Mohseni, Umut Gurkan, Vivien Sheehan

Blood (2025) 146 (Supplement 1): 6136.

https://doi.org/10.1182/blood-2025-6136

Published: 2025

Journal Articles

Biophysical characterization of red blood cells in sickle cell trait reveals heterogeneous and intermediate pathophysiological profiles

Zoe Sekyonda, Payam Fadaei, Yuxuan Du, Chiara Federici, Mohan Madisetti, Najibah Galadanci, Rakhi Naik, Julie Kanter, Umut Gurkan

Blood (2025) 146 (Supplement 1): 1156.

https://doi.org/10.1182/blood-2025-1156

Published: 2025

Journal Articles

High-throughput oxygen dissociation assay enables rapid screening of hemoglobin oxygen affinity modifying therapies

Zoe Sekyonda, William Wulftange, Ozan Akkus, Umut Gurkan

Blood (2025) 146 (Supplement 1): 6493.

https://doi.org/10.1182/blood-2025-6493

Published: 2025

Journal Articles

Novel microfluidic rheology assay for in vitro-differentiated red blood cells: Enhancing quality control and therapeutic evaluation in sickle cell disease gene therapies

Solomon Oshabaheebwa, Yuxuan Du, Christopher Wirth, Zoe Sekyonda, Bryan Benson, Payam Fadaei, Yusang Ley, Utku Goreke, Nathan Perez, Petros Giannikopoulos, David Nguyen, Michael Suster, Pedram Mohseni, Umut Gurkan

Blood (2025) 146 (Supplement 1): 6489.

https://doi.org/10.1182/blood-2025-6489

Published: 2025

Journal Articles

Clot Strength Is Affected By the Heterogeneity of Red Blood Cells in Sickle Cell Disease

Calvin Abonga, Zoe Sekyonda, Hanif Alizadeh, Michael A. Suster, Umut Gurkan, Pedram Mohseni

Blood (2024) 144 (Supplement 1): 5280.

https://doi.org/10.1182/blood-2024-208517

Published: 2024

Journal Articles

Methods to Assess the Impact of Combined Pharmacologic and Transfusion Therapies on Red Cell Deformability

Abhinav K Pasupuleti, Akshay A Patwardhan, Ashwin P. Patel, Solomon Oshabaheebwa, Christopher A. Delianides, Zoe Sekyonda, Erica N Evans, Lindsey Abel, Michael A. Suster, Pedram Mohseni, Umut Gurkan, Vivien Sheehan

Blood (2024) 144 (Supplement 1): 7510.

https://doi.org/10.1182/blood-2024-207680

Published: 2024

Journal Articles

Proposed Use of the Microfluidic Impedance Red Cell Assay (MIRCA) to Identify Individuals with Sickle Cell Disease in Need of Second Line Therapies

Akshay A Patwardhan, Ashwin P. Patel, Solomon Oshabaheebwa, Christopher A. Delianides, Zoe Sekyonda, Erica N Evans, Abhinav K Pasupuleti, Lindsey Abel, Michael A. Suster, Pedram Mohseni, Umut Gurkan, Vivien Sheehan

Blood (2024) 144 (Supplement 1): 2216.

https://doi.org/10.1182/blood-2024-205913

Published: 2024

Journal Articles

A Whole Blood-Based Assay for Assessing Red Blood Cell-Mediated Microcapillary Occlusion in Sickle Cell Disease

Solomon Oshabaheebwa, Yusang M. Bejarano Ley, Christopher A. Delianides, Zoe Sekyonda, Vivien Sheehan, Michael A. Suster, Pedram Mohseni, Umut Gurkan

Blood (2024) 144 (Supplement 1): 5285.

https://doi.org/10.1182/blood-2024-210645

Published: 2024

Journal Articles

Voxelotor and Red Blood Cell Pyruvate Kinase Activator Enhance Sickle Erythrocyte Deformability By Calcium Efflux

Zoe Sekyonda, Solomon Oshabaheebwa, Ada Chang, Jane A. Little, Umut Gurkan

Blood (2024) 144 (Supplement 1): 1101.

https://doi.org/10.1182/blood-2024-210758

Published: 2024

Journal Articles

The Intracellular Effects of Anti-Polymerizing RNA Aptamers in Sickled Red Blood Cells

Alicia Matthews, Christopher Hu, Zoe Sekyonda, Umut Gurkan, Yolanda Fortenberry

Blood (2024) 144 (Supplement 1): 3873.

https://doi.org/10.1182/blood-2024-210571

Published: 2024

Journal Articles

A Miniaturized, Rapid Technique for Measuring Red Blood Cell-Mediated Microcapillary Occlusion in HbAS, HbSC, and HbSS Sickle Cell Disease Genotypes

Solomon Oshabaheebwa, Christopher A. Delianides, Zoe Sekyonda, Yusang M. Bejarano Ley, Calvin Abonga, Vivien A Sheehan, Michael A. Suster, Pedram Mohseni, Umut A. Gurkan

Blood (2023) 142 (Supplement 1): 5022.

https://doi.org/10.1182/blood-2023-187259

Published: 2023

Journal Articles

Rapid Assessment of Hemoglobin-Oxygen Dissociation

Zoe Sekyonda, Cissy Kityo, Yasmin Elgammal, Theodosia A. Kalfa, Ozan Akkus, Umut A. Gurkan

Blood (2023) 142 (Supplement 1): 2270.

https://doi.org/10.1182/blood-2023-187503

Published: 2023

Journal Articles

Comparison of Devices That Measure Sickle Red Cell Deformability

Akshay A Patwardhan, Solomon Oshabaheebwa, Christopher A. Delianides, Zoe Sekyonda, Ashwin P Patel, Erica N Evans, Justin J Yoo, Lindsey Abel, Michael A. Suster, Pedram Mohseni, Umut A. Gurkan, Vivien A Sheehan

Blood (2023) 142 (Supplement 1): 3669.

https://doi.org/10.1182/blood-2023-187557

Published: 2023

Journal Articles

Voxelotor and Red Blood Cell Pyruvate Kinase Activator Affect Clot Strength in Sickle Cell Disease

Zoe Sekyonda, Calvin Abonga, Christopher A. Delianides, Solomon Oshabaheebwa, Jane A. Little, Michael A. Suster, Pedram Mohseni, Umut A. Gurkan

Blood (2023) 142 (Supplement 1): 1114.

https://doi.org/10.1182/blood-2023-187577

Published: 2023

Journal Articles

Effect of Voxelotor on Red Blood Cell Adhesion Under Normoxia Using an Endothelialized Microfluidic System

Neha J. Desai, Chiara Federici, Aaron Wolfe, Zoe Sekyonda, Allison Bode, Amma Owusu-Ansah, Umut A. Gurkan

Blood (2022) 140 (Supplement 1): 11093–11094.

https://doi.org/10.1182/blood-2022-164818

Published: 2022

Journal Articles

Sickling Dynamics Differ Among the Different Sickle Cell Disease Genotypes

Zoe Sekyonda, Utku Goreke, Ran An, Solomon Oshabaheebwa, Yuncheng Man, Umut A. Gurkan

Blood (2022) 140 (Supplement 1): 5401–5402.

https://doi.org/10.1182/blood-2022-164768

Published: 2022

Journal Articles

Hypoxia Impact on Red Blood Cell-Mediated Microvascular Occlusion and Adhesion in Sickle Cell Disease and Sickle Cell Trait

Yuncheng Man, Zoe Sekyonda, Karamoja Monchamp, Ran An, Erdem Kucukal, Chiara Federici, Lalitha V Nayak, Jane A. Little, Umut A. Gurkan

Blood (2021) 138 (Supplement 1): 966.

https://doi.org/10.1182/blood-2021-149121

Published: 2021

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Sickling kinetics drive genotype-specific impairment of RBC deformability in sickle cell disease

Acidosis and hypoxia cooperatively impair immune cell infiltration in a microengineered tumor microenvironment

Alpha-thalassemia and red blood cell heterogeneity in sickle cell trait: Interim findings from the achieving understanding of the natural history of sickle cell trait (AUNT) study

Use of red cell deformability measurements to assess the impact of pyruvate kinase activators on combined drug and transfusion therapies

Biophysical characterization of red blood cells in sickle cell trait reveals heterogeneous and intermediate pathophysiological profiles

High-throughput oxygen dissociation assay enables rapid screening of hemoglobin oxygen affinity modifying therapies

Novel microfluidic rheology assay for in vitro-differentiated red blood cells: Enhancing quality control and therapeutic evaluation in sickle cell disease gene therapies

Clot Strength Is Affected By the Heterogeneity of Red Blood Cells in Sickle Cell Disease

Methods to Assess the Impact of Combined Pharmacologic and Transfusion Therapies on Red Cell Deformability

Proposed Use of the Microfluidic Impedance Red Cell Assay (MIRCA) to Identify Individuals with Sickle Cell Disease in Need of Second Line Therapies

A Whole Blood-Based Assay for Assessing Red Blood Cell-Mediated Microcapillary Occlusion in Sickle Cell Disease

Voxelotor and Red Blood Cell Pyruvate Kinase Activator Enhance Sickle Erythrocyte Deformability By Calcium Efflux

The Intracellular Effects of Anti-Polymerizing RNA Aptamers in Sickled Red Blood Cells

A Miniaturized, Rapid Technique for Measuring Red Blood Cell-Mediated Microcapillary Occlusion in HbAS, HbSC, and HbSS Sickle Cell Disease Genotypes

Rapid Assessment of Hemoglobin-Oxygen Dissociation

Comparison of Devices That Measure Sickle Red Cell Deformability

Voxelotor and Red Blood Cell Pyruvate Kinase Activator Affect Clot Strength in Sickle Cell Disease

Effect of Voxelotor on Red Blood Cell Adhesion Under Normoxia Using an Endothelialized Microfluidic System

Sickling Dynamics Differ Among the Different Sickle Cell Disease Genotypes

Hypoxia Impact on Red Blood Cell-Mediated Microvascular Occlusion and Adhesion in Sickle Cell Disease and Sickle Cell Trait

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American Society of Hematology

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ASH Publications

American Society of Hematology

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