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Journal Articles

Cd39 overexpression in AML blasts elicits an immune suppressive bone barrow microenvironment via G3/G4 neutrophils and Th1 cells

Hanheng Mai, Hui Yuan, Yunqing Liu, Tan Sang, Zonghong Li, Xiuyan Chen, Jinming Yu, Y. Lynn Wang, Lili Feng

Blood (2025) 146 (Supplement 1): 1469.

https://doi.org/10.1182/blood-2025-1469

Published: 2025

Journal Articles

Pharmacokinetic failure of obinutuzumab due to massive third-space sequestration in a patient with high-burden follicular lymphoma: A rationale for therapeutic drug monitoring and dose intensification

Rong Xie, Qiang He, Hanheng Mai, Lili Feng, Yiwen Huang, Li Zhang, Ziqing Ma, Yuhong Ba, Kuntong Liu, Y. Lynn Wang, Ji Ma

Blood (2025) 146 (Supplement 1): 7131.

https://doi.org/10.1182/blood-2025-7131

Published: 2025

Journal Articles

Harnessing BCL2 inhibition with BTK inhibition in follicular lymphoma: A translational trial with mechanistic insights from single cell analysis

Pin Lu, Tingwei Guo, YunYun Zhou, Cosimo Lobello, Bryant Schultz, Yinfei Tan, Johanna James, Denise Connolly, Shazia Nakhoda, Marcus Messmer, Y. Lynn Wang

Blood (2025) 146 (Supplement 1): 3313.

https://doi.org/10.1182/blood-2025-3313

Published: 2025

Journal Articles

Clinical efficacy and safety of polatuzumab vedotin, rituximab, and zanubrutinib (POLA-Z-R) therapy in treatment of super-elderly patients with DLBCL: A real-world retrospective study

Rong Xie, Qiang He, Linna Xie, Lili Feng, Qi Kong, Kuntong Liu, Ziqing Ma, Yuhong Ba, Zonghong Li, Qian Wu, Tan Sang, Y. Lynn Wang, Ji Ma

Blood (2025) 146 (Supplement 1): 7221.

https://doi.org/10.1182/blood-2025-7221

Published: 2025

Journal Articles

Clinical Validation of a Personalized NHL-TME Model System: One-on-One Comparison between Modeled Drug Responses and Patients' Clinical Responses

Shazia K. Nakhoda, Pin Lu, Tingwei Guo, Denise Connelly, Marcus Messmer, Zachary AK Frosch, Henry C. Fung, Asya Varshavsky Yanovsky, Y. Lynn Wang

Blood (2024) 144 (Supplement 1): 2214.

https://doi.org/10.1182/blood-2024-203843

Published: 2024

Journal Articles

Inosine Monophosphate Dehydrogenase-2 (IMPDH2) As the Potential Novel Therapeutic Target in Mantle Cell Lymphoma (MCL): The Underlying Tyrosine Phosphorylation-Based Activation Mechanism and Translational Implications

Johnvesly Basappa, Shengchun Wang, Cosimo Lobello, David Rushmore, Olga Melnikov, Neil Sen, Vinay Mallikarjuna, Priyanka Jain, Pin Lu, Y. Lynn Wang, Kathy Cai, Reza Nejati, Aaron Goldman, Mariusz Wasik

Blood (2024) 144 (Supplement 1): 1602.

https://doi.org/10.1182/blood-2024-203257

Published: 2024

Journal Articles

Uncovering Therapeutic Resistance in BPDCN through Single-Cell Transcriptome Profiling

Ji Ma, Qiang He, Qian Wu, Lili Feng, Y. Lynn Wang, Linna Xie

Blood (2024) 144 (Supplement 1): 1557.

https://doi.org/10.1182/blood-2024-204227

Published: 2024

Journal Articles

Live Lymphoma and CLL Cells inside the Bone Marrow Fibroblasts: Implication in Residual Disease Persistence

Y. Lynn Wang, Carrie Frazen, Andrey Efimov, Priyal Patel, Pin Lu, Shuo Ma, Katherine Amira Carrol, Edna Cukierman, Marcus R. Messmer, Janusz Franco-Barraza, Juehua Gao, Aldana Vistarop

Blood (2023) 142 (Supplement 1): 6506.

https://doi.org/10.1182/blood-2023-179994

Published: 2023

Journal Articles

Molecular Monitoring with Tumor DNA and Nivolumab Maintenance: A Pilot Study in Diffuse Large B-Cell Lymphoma

Shazia Nakhoda, Tamarrah Sklarz, Cheyenne Pagan, Matthew Matasar, Marcus Messmer, Zachary AK Frosch, Y. Lynn Wang, Asya Varshavsky Yanovsky, Rashmi Khanal, Carlyn Rose Tan, Henry C. Fung, Eli Mikkelsen, Kevin A. David, Mark Roschewski, Eric Ross, Allison P. Jacob, Erin Ahn, Nadia Khan

Blood (2023) 142 (Supplement 1): 6231.

https://doi.org/10.1182/blood-2023-179980

Published: 2023

Journal Articles

Zanubrutinib PLUS RCHOP(ZR-CHOP) Regimen Achieves High Complete Response Rate in the Treatment of Newly-Diagnosed Double-Expression Diffuse Large B Cell Lymphoma

Qiang He, Linna Xie, Rongrong Zhao, Ji Ma, Hui Wang, Jie Li, Chuanli Zhao, Y. Lynn Wang, Zengjun Li

Blood (2022) 140 (Supplement 1): 6614–6615.

https://doi.org/10.1182/blood-2022-168859

Published: 2022

Journal Articles

SHP1 Loss Augments DLBCL Cellular Response to Ibrutinib: A Candidate Predictive Biomarker

Y. Lynn Wang, Ji Ma, Vinay Mallikarjuna, Pin Lu, Shengchun Wang, Sahar Poureghbali, Mariusz A Wasik, Reza Nejati, Wenjun Wu

Blood (2021) 138 (Supplement 1): 3490.

https://doi.org/10.1182/blood-2021-146086

Published: 2021

Journal Articles

XPO1 Inhibitor Selinexor Overcomes Ibrutinib Resistance in Mantle Cell Lymphoma Via Nuclear Retention of IκB

Y. Lynn Wang, MD PhD, Mei Ming, PhD, Bingqing Xie, Madina Sukhanova, Weige Wang, MD, Sabah Kadri, PhD, Shruti Sharma, Jimmy Lee, Sharon Shacham, PhD MBA, Yosef Landesman, PhD, Natalia Maltsev, Pin Lu, PhD

Blood (2017) 130 (Supplement 1): 3837.

https://doi.org/10.1182/blood.V130.Suppl_1.3837.3837

Published: 2017

Journal Articles

PET-CT Invisible Diffuse Large B-Cell Lymphoma Features a Silent B-Cell Receptor Signaling

Dong Sheng, MD, Ting Li, MD, Xiangnan Jiang, MD, Weige Wang, MD, Y. Lynn Wang, MD PhD, Xiaoqiu Li

Blood (2017) 130 (Supplement 1): 2853.

https://doi.org/10.1182/blood.V130.Suppl_1.2853.2853

Published: 2017

Journal Articles

RAC2 Links B-Cell Receptor Signaling and Cell Adhesion in Mantle Cell Lymphoma

Weige Wang, Franzen Carrie, Madina Sukhanova, Venkataraman Girish, Ming Mei, Guo Ailin, Pin Lu, PhD, Dong Sheng, MD, Gao Anhui, Xia Chunmei, Li Jia, Zhou Xiaoyan, Y Lynn Wang

Blood (2017) 130 (Supplement 1): 2752.

https://doi.org/10.1182/blood.V130.Suppl_1.2752.2752

Published: 2017

Journal Articles

Clonal Evolution Pattern of Leukemia Progression and Richter Transformation in Ibrutinib-Relapsed CLL Patients

Blood (2016) 128 (22): 3961.

https://doi.org/10.1182/blood.V128.22.3961.3961

Published: 2016

Journal Articles

Genetic or CD40L-Mediated Loss of Iκbα Is Associated with Resistance to the Dual SYK/JAK Inhibitor Cerdulatinib in DLBCL Cell Lines

Greg P Coffey, PhD, Jiajia Feng, MD, Sabah Kadri, PhD, Y. Lynn Wang, MD PhD, Pin Lu, PhD, Shruti Sharma, PhD, Jeremy Segal, PhD, Glenn Michelson, MD, Anjali Pandey, PhD, John T. Curnutte, MD PhD, Pamela B. Conley, PhD

Blood (2016) 128 (22): 2768.

https://doi.org/10.1182/blood.V128.22.2768.2768

Published: 2016

Journal Articles

SYK and STAT3 Are Active in Diffuse Large B-Cell Lymphoma: Activity of Cerdulatinib, a Dual SYK/JAK Inhibitor

Y. Lynn Wang, MD PhD, Jiao Ma, PhD, Wei Xing, PhD, Pin Lu, MD PhD, Karen Dresser, Ailin Guo, PhDMD, Anjali Pandey, PhD, Pamela B. Conley, PhD, Hongbo Yu, MD PhD, Greg Coffey, PhD

Blood (2014) 124 (21): 926.

https://doi.org/10.1182/blood.V124.21.926.926

Published: 2014

Journal Articles

A Novel Mutation In Bruton Tyrosine Kinase Confers Acquired Resistance To Ibrutinib (PCI-32765) In CLL

Richard R. Furman, MD, Shuhua Cheng, PhD, Pin Lu, MD, PhD, Menu Setty, Alexandar Perez, Ailin Guo, MD, PhD, Joelle Racchumi, BS, Jiao Ma, PhD, Morton Coleman, MD, Kabaleeswaran Venkataraman, PhD, Guozhou Xu, PhD, Wei Chen, PhD, Hao Wu, PhD, Betty Y. Chang, PhD, Christina Leslie, PhD, Y. Lynn Wang, MD, PhD

Blood (2013) 122 (21): 4914.

https://doi.org/10.1182/blood.V122.21.4914.4914

Published: 2013

Journal Articles

Dual SYK/JAK Inhibition Has a Broader Anti-Tumor Activity In Both ABC and GCB Types Of Diffuse Large B Cell Lymphoma

Jiao Ma, PhD, Greg Coffey, PhD, Pin Lu, MD, PhD, Shuhua Cheng, PhD, Ailin Guo, MD, PhD, Anjali Pandey, PhD, Y. Lynn Wang, MD, PhD

Blood (2013) 122 (21): 1833.

https://doi.org/10.1182/blood.V122.21.1833.1833

Published: 2013

Journal Articles

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies

Utthara Nayar, Pin Lu, Rebecca L. Goldstein, Jelena Vider, Gianna Ballon, Anna Rodina, Tony Taldone, Hediye Erdjument-Bromage, Max Chomet, Ronald Blasberg, Ari Melnick, Leandro Cerchietti, Gabriela Chiosis, Y. Lynn Wang, Ethel Cesarman

Blood (2013) 122 (16): 2837–2847.

https://doi.org/10.1182/blood-2013-01-479972

Published: 2013

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Cd39 overexpression in AML blasts elicits an immune suppressive bone barrow microenvironment via G3/G4 neutrophils and Th1 cells

Pharmacokinetic failure of obinutuzumab due to massive third-space sequestration in a patient with high-burden follicular lymphoma: A rationale for therapeutic drug monitoring and dose intensification

Harnessing BCL2 inhibition with BTK inhibition in follicular lymphoma: A translational trial with mechanistic insights from single cell analysis

Clinical efficacy and safety of polatuzumab vedotin, rituximab, and zanubrutinib (POLA-Z-R) therapy in treatment of super-elderly patients with DLBCL: A real-world retrospective study

Clinical Validation of a Personalized NHL-TME Model System: One-on-One Comparison between Modeled Drug Responses and Patients' Clinical Responses

Inosine Monophosphate Dehydrogenase-2 (IMPDH2) As the Potential Novel Therapeutic Target in Mantle Cell Lymphoma (MCL): The Underlying Tyrosine Phosphorylation-Based Activation Mechanism and Translational Implications

Uncovering Therapeutic Resistance in BPDCN through Single-Cell Transcriptome Profiling

Live Lymphoma and CLL Cells inside the Bone Marrow Fibroblasts: Implication in Residual Disease Persistence

Molecular Monitoring with Tumor DNA and Nivolumab Maintenance: A Pilot Study in Diffuse Large B-Cell Lymphoma

Zanubrutinib PLUS RCHOP(ZR-CHOP) Regimen Achieves High Complete Response Rate in the Treatment of Newly-Diagnosed Double-Expression Diffuse Large B Cell Lymphoma

SHP1 Loss Augments DLBCL Cellular Response to Ibrutinib: A Candidate Predictive Biomarker

XPO1 Inhibitor Selinexor Overcomes Ibrutinib Resistance in Mantle Cell Lymphoma Via Nuclear Retention of IκB

PET-CT Invisible Diffuse Large B-Cell Lymphoma Features a Silent B-Cell Receptor Signaling

RAC2 Links B-Cell Receptor Signaling and Cell Adhesion in Mantle Cell Lymphoma

Clonal Evolution Pattern of Leukemia Progression and Richter Transformation in Ibrutinib-Relapsed CLL Patients

Genetic or CD40L-Mediated Loss of Iκbα Is Associated with Resistance to the Dual SYK/JAK Inhibitor Cerdulatinib in DLBCL Cell Lines

SYK and STAT3 Are Active in Diffuse Large B-Cell Lymphoma: Activity of Cerdulatinib, a Dual SYK/JAK Inhibitor

A Novel Mutation In Bruton Tyrosine Kinase Confers Acquired Resistance To Ibrutinib (PCI-32765) In CLL

Dual SYK/JAK Inhibition Has a Broader Anti-Tumor Activity In Both ABC and GCB Types Of Diffuse Large B Cell Lymphoma

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies

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