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Nicholas Haradhvala
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Journal Articles

Pre-existing cytotoxic capacity of CD8+ and CD4+ T cells is a hallmark of richter transformation and favors response to anti-PD-1 therapy

Free
Johan Gustafsson, Chiara Tomasoni, Graydon Moorhead, Gabriela Brunsting Hoffmann, Erik Landolsi, Wesley Lu, Ruitong Li, Shuqiang Li, Nicholas Haradhvala, Connor Johnson, Stephanie Deng, Donna Neuberg, Xia Bu, Gordon Freeman, Othman Al-Sawaf, Barbara Eichhorst, Erin Parry, Gad Getz, Catherine Wu, Elisa Ten Hacken
Journal: Blood
Blood (2025) 146 (Supplement 1): 243.
https://doi.org/10.1182/blood-2025-243
Published: 2025
Journal Articles

Triple base-edited dual targeting CD70/33 CAR T cells to avoid cytokine-mediated resistance in Acute Myeloid Leukemia

Free
Alexandra Bratt, Grace Martin, Merle Phillips, Sophia Nigrovic, Filippo Birocchi, Cassiddy Ho, Andrew Hwang, Adele Mucci, Nicholas Haradhvala, Magdi Elsallab, Marcela Maus, Mark Leick
Journal: Blood
Blood (2025) 146 (Supplement 1): 5879.
https://doi.org/10.1182/blood-2025-5879
Published: 2025
Journal Articles

Single-cell transcriptomics reveal mechanisms of efficacy and toxicity in anti-BCMA CAR-T cell therapies for multiple myeloma

Free
Xiaomeng Sun, Charlotte Graham, Aiyana Parker, Maria Dolaher, Kevin Lindell, Deshea L Harris, Won-Ho Lee, Kiana Graham, Hannah Nolan, Viktoria Blumenberg, David Bozym, Diana Cirstea, Andrew Branagan, Andrew Yee, Noopur Raje, Mark Leick, Matthew Frigault, Kathleen ME Gallagher, Nicholas Haradhvala, Gad Getz, Marcela Maus
Journal: Blood
Blood (2025) 146 (Supplement 1): 503.
https://doi.org/10.1182/blood-2025-503
Published: 2025
Journal Articles

Polyfunctional Effector PD-1 + CD8 + T Cells and M1 Macrophages Promote Immune Checkpoint Blockade Response in Richter Syndrome Mouse Models

Free
Elisa Ten Hacken, Johan Gustafsson, Chiara Tomasoni, Gabriela Brunsting Hoffmann, Kayla Cruz, Wesley S Lu, Shuqiang Li, Nicholas Haradhvala, Connor Johnson, Stephanie Deng, Xia Bu, Donna S. Neuberg, Othman Al-Sawaf, Barbara F. Eichhorst, Clare Sun, Erin M. Parry, Gordon J. Freeman, Gad Getz, Catherine J. Wu
Journal: Blood
Blood (2024) 144 (Supplement 1): 761.
https://doi.org/10.1182/blood-2024-201006
Published: 2024
Journal Articles

Single Cell Characterization of Myeloma and Its Precursor Conditions Reveals Transcriptional Signatures of Early Tumorigenesis

Free
Rebecca Boiarsky, Nicholas Haradhvala, Romanos Sklavenitis-Pistofidis, Tarek H Mouhieddine, Jean-Baptiste Alberge, Oksana Zavidij, Danielle Firer, Shankara Anand, Habib El-Khoury, François Aguet, David Sontag, Irene M. Ghobrial, Gad Getz
Journal: Blood
Blood (2021) 138 (Supplement 1): 2219.
https://doi.org/10.1182/blood-2021-150889
Published: 2021
Journal Articles

Single-Cell RNA-Sequencing Identifies Immune Biomarkers of Response to Immunotherapy in Patients with High-Risk Smoldering Myeloma

Free
Romanos Sklavenitis-Pistofidis, Ankit K. Dutta, Sylvia Ujwary, Robert A. Redd, Alexandra Savell, Léa Fléchon, François Aguet, Nicholas Haradhvala, Oksana Zavidij, Mark Bustoros, Sabrin Tahri, Tarek H Mouhieddine, Nang K. Su, Lily Ardente, Shankara Anand, Jacalyn Rosenblatt, Jeffrey A. Zonder, James J. Vredenburgh, Adam Boruchov, Manisha Bhutani, Saad Z. Usmani, Jeffrey V. Matous, Andrew J. Yee, Andrzej Jakubowiak, Claudia E. Paba-Prada, Julia Prescott, Jacob P. Laubach, Salomon Manier, Omar Nadeem, Paul G. Richardson, Ashraf Z. Badros, Lorenzo Trippa, Maria-Victoria Mateos, Gad Getz, Irene M. Ghobrial
Journal: Blood
Blood (2021) 138 (Supplement 1): 330.
https://doi.org/10.1182/blood-2021-147623
Published: 2021
Journal Articles

Dissecting the Epigenetic Landscape of Smoldering, Newly Diagnosed and Relapsed Multiple Myeloma Revealed IRAK3 As a Marker of Disease Progression

Free
Mahshid Rahmat, PhD, Nicholas Haradhvala, BA, Romanos Sklavenitis-Pistofidis, MD, Jihye Park, PhD, Daisy Huynh, MS, Mark Bustoros, MD, Brianna Berrios, BS, Mairead Reidy, PhD, Adriana Perilla-Glen, Bradley Rivotto, BS, Kalvis Hornburg, BA, David M. Dorfman, MD, PhD, Jonathan D. Licht, MD, Gad Getz, PhD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3896.
https://doi.org/10.1182/blood-2018-99-115046
Published: 2018
Journal Articles

Single-Cell RNA Sequencing Reveals Compromised Immune Microenvironment in Precursor Stages of Multiple Myeloma

Free
Oksana Zavidij, PhD, Nicholas Haradhvala, BA, Tarek H Mouhieddine, MD, Jihye Park, PhD, Romanos Pistofidis, MD, Mairead Reidy, PhD, Daisy Huynh, MS, Marzia Capelletti, PhD, Brianna Berrios, BS, Mahshid Rahmat, PhD, Mark Bustoros, MD, Chia-Jen Liu, MD, Meng Xiao He, AB, Yosef Maruvka, PhD, Bradley Rivotto, BS, Kalvis Hornburg, BA, Melissa Goldman, PhD, Eliezer Van Allen, MD, Steven A McCarroll, PhD, Jamil Azzi, MD, Gad Getz, PhD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2603.
https://doi.org/10.1182/blood-2018-99-114145
Published: 2018