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Journal Articles

A structural spotlight on extrinsic Xase complex

Lacramioara Ivanciu

Blood (2025) 146 (23): 2742–2743.

https://doi.org/10.1182/blood.2025030904

Published: 2025

Journal Articles

Identification of genetic loci regulating plasma and platelet factor v expression in mice

Arina Rodionova, Adrianna Jurek, Kailey MacFadyen, Marisa Brake, Lacramioara Ivanciu, Rodney Camire, Randal Westrick

Blood (2025) 146 (Supplement 1): 6607.

https://doi.org/10.1182/blood-2025-6607

Published: 2025

Journal Articles

Hepatic plasminogen lowering with a galnac-conjugated siRNA reduces plasmin generation and fibrinolysis but has no effect on thrombin generation in rats and mice

Caitlin Cevasco, Lacramioara Ivanciu, John Gansner, Rodney Camire, Martina Lundberg Slingsby

Blood (2025) 146 (Supplement 1): 3058.

https://doi.org/10.1182/blood-2025-3058

Published: 2025

Journal Articles

Comparison of hemostatic dosing of factor IX wild-type and padua (R338L) in multiple hemophilia B mouse models

Julia Chau, Sebastian Leyes Porello, Lacramioara Ivanciu, Ben Samelson-Jones

Blood (2025) 146 (Supplement 1): 4831.

https://doi.org/10.1182/blood-2025-4831

Published: 2025

Journal Articles

Mim8 improves the In Vivo hemostasis of select hemophilia B causing factor IX variants

Sebastian Leyes Porello, Kyumin Lee, Julia Chau, Lacramioara Ivanciu, Shelley Nakaya Fletcher, Jill Johnsen, Jacob Lund, Ben Samelson-Jones

Blood (2025) 146 (Supplement 1): 4830.

https://doi.org/10.1182/blood-2025-4830

Published: 2025

Journal Articles

Factor IXa variants resistant to plasma inhibitors enhance clot formation in vivo

Lacramioara Ivanciu, Valder R. Arruda, Rodney M. Camire

Blood (2023) 141 (16): 2022–2032.

https://doi.org/10.1182/blood.2022018083

Published: 2023

Includes: Multimedia, Supplemental data

Journal Articles

An Antibody Targeting Human FV Promotes Thrombin Generation and Reduces Bleeding in a Hemophilic Mouse Model

Sean Quinn, Lacramioara Ivanciu, Robert J. Davidson, Francis Ayombil, Rodney M. Camire

Blood (2022) 140 (Supplement 1): 963–964.

https://doi.org/10.1182/blood-2022-157997

Published: 2022

Journal Articles

Protection of Human Factor V from Activated Protein C Using a Monoclonal Antibody-Biochemical Characterization and Evaluation Using a Mouse Injury Model

Sean Quinn, Lacramioara Ivanciu, Robert J. Davidson, Francis Ayombil, Jeffrey Crosby, Alexey Revenko, Robert A. MacLeod, Brett P Monia, Rodney M. Camire

Blood (2021) 138 (Supplement 1): 2092.

https://doi.org/10.1182/blood-2021-153527

Published: 2021

Journal Articles

Differential Role of Plasma and Platelet-Derived Factor V In Vivo

Lacramioara Ivanciu, PhD, Jeffrey Crosby, PhD, Alexey Revenko, PhD, A. Robert MacLeod, PhD, Brett P. Monia, PhD, Robert J. Davidson, BS, Rodney M Camire, PhD

Blood (2017) 130 (Supplement 1): 364.

https://doi.org/10.1182/blood.V130.Suppl_1.364.364

Published: 2017

Journal Articles

Design and characterization of an APC-specific serpin for the treatment of hemophilia

Stéphanie G. I. Polderdijk, Ty E. Adams, Lacramioara Ivanciu, Rodney M. Camire, Trevor P. Baglin, James A. Huntington

Blood (2017) 129 (1): 105–113.

https://doi.org/10.1182/blood-2016-05-718635

Published: 2017

Includes: Supplemental data

Journal Articles

A Single Amino Acid in the Gla Domain Mouse FVIIa Allows Its Binding to the Endothelial Protein C Receptor and Enhances Its Coagulant Activity In Vivo

Giulia Pavani, PhD, Lacramioara Ivanciu, PhD, Katherine A. Stafford, Paris Margaritis, DPhil

Blood (2015) 126 (23): 3489.

https://doi.org/10.1182/blood.V126.23.3489.3489

Published: 2015

Journal Articles

Hemostatic agents of broad applicability produced by selective tuning of factor Xa zymogenicity

Lacramioara Ivanciu, Rodney M. Camire

Blood (2015) 126 (1): 94–102.

https://doi.org/10.1182/blood-2015-03-634329

Published: 2015

Includes: Supplemental data

Journal Articles

Zymogen-like FXa Is a Potent Bypassing Agent for Reversal of Direct FXa Inhibitors in Vivo

Nabil K. Thalji, BS, Lacramioara Ivanciu, PhD, Reema Jasuja, Sunita Patel-Hett, PhD, Joachim Fruebis, PhD, Debra Pittman, Rodney M. Camire, PhD

Blood (2014) 124 (21): 582.

https://doi.org/10.1182/blood.V124.21.582.582

Published: 2014

Journal Articles

New insights into the spatiotemporal localization of prothrombinase in vivo

Lacramioara Ivanciu, Sriram Krishnaswamy, Rodney M. Camire

Blood (2014) 124 (11): 1705–1714.

https://doi.org/10.1182/blood-2014-03-565010

Published: 2014

Includes: Multimedia, Supplemental data

Journal Articles

The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo

Giulia Pavani, Lacramioara Ivanciu, Armida Faella, Oscar A. Marcos-Contreras, Paris Margaritis

Blood (2014) 124 (7): 1157–1165.

https://doi.org/10.1182/blood-2014-04-567297

Published: 2014

Includes: Supplemental data

Journal Articles

Bioengineering Factor VIII B-Domain Sequences Improves Function and Efficacy in Hemophilia A Models.

Joshua I Siner, Nicholas P Iacobelli, Lacramioara Ivanciu, Ph.D., Denise E. Sabatino, Ph.D., Mortimer Poncz, MD, Rodney M. Camire, PhD, Valder R Arruda, MD, PhD

Blood (2012) 120 (21): 2208.

https://doi.org/10.1182/blood.V120.21.2208.2208

Published: 2012

Journal Articles

FVIIa Binding to the Endothelial Protein C Receptor Reduces Protein Recovery in Vivo

Giulia Pavani, MS, Lacramioara Ivanciu, PhD, Paris Margaritis, DPhil

Blood (2012) 120 (21): 18.

https://doi.org/10.1182/blood.V120.21.18.18

Published: 2012

Journal Articles

Engineered factor IX variants bypass FVIII and correct hemophilia A phenotype in mice

Peter Milanov, Lacramioara Ivanciu, Daniela Abriss, Patricia Quade-Lyssy, Wolfgang Miesbach, Sonja Alesci, Torsten Tonn, Manuel Grez, Erhard Seifried, Jörg Schüttrumpf

Blood (2012) 119 (2): 602–611.

https://doi.org/10.1182/blood-2011-05-353672

Published: 2012

Journal Articles

Selective Alteration of FXa Zymogenicity Provides a Dynamic Range of Variants that Improve Hemostasis in Hemophilia

Lacramioara Ivanciu, PhD, Rodney M. Camire, PhD

Blood (2011) 118 (21): 201.

https://doi.org/10.1182/blood.V118.21.201.201

Published: 2011

Journal Articles

Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo

Paris Margaritis, Elise Roy, Armida Faella, Harre D. Downey, Lacramioara Ivanciu, Giulia Pavani, Shangzhen Zhou, Ralph M. Bunte, Katherine A. High

Blood (2011) 117 (15): 3974–3982.

https://doi.org/10.1182/blood-2010-09-309732

Published: 2011

Includes: Supplemental data

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A structural spotlight on extrinsic Xase complex

Identification of genetic loci regulating plasma and platelet factor v expression in mice

Hepatic plasminogen lowering with a galnac-conjugated siRNA reduces plasmin generation and fibrinolysis but has no effect on thrombin generation in rats and mice

Comparison of hemostatic dosing of factor IX wild-type and padua (R338L) in multiple hemophilia B mouse models

Mim8 improves the In Vivo hemostasis of select hemophilia B causing factor IX variants

Factor IXa variants resistant to plasma inhibitors enhance clot formation in vivo

An Antibody Targeting Human FV Promotes Thrombin Generation and Reduces Bleeding in a Hemophilic Mouse Model

Protection of Human Factor V from Activated Protein C Using a Monoclonal Antibody-Biochemical Characterization and Evaluation Using a Mouse Injury Model

Differential Role of Plasma and Platelet-Derived Factor V In Vivo

Design and characterization of an APC-specific serpin for the treatment of hemophilia

A Single Amino Acid in the Gla Domain Mouse FVIIa Allows Its Binding to the Endothelial Protein C Receptor and Enhances Its Coagulant Activity In Vivo

Hemostatic agents of broad applicability produced by selective tuning of factor Xa zymogenicity

Zymogen-like FXa Is a Potent Bypassing Agent for Reversal of Direct FXa Inhibitors in Vivo

New insights into the spatiotemporal localization of prothrombinase in vivo

The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo

Bioengineering Factor VIII B-Domain Sequences Improves Function and Efficacy in Hemophilia A Models.

FVIIa Binding to the Endothelial Protein C Receptor Reduces Protein Recovery in Vivo

Engineered factor IX variants bypass FVIII and correct hemophilia A phenotype in mice

Selective Alteration of FXa Zymogenicity Provides a Dynamic Range of Variants that Improve Hemostasis in Hemophilia

Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo

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American Society of Hematology

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