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Johanna Rausch
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Journal Articles

Menin-inhibition boosts CAR-T cell therapy against NPM1 mutated and KMT2A-rearranged acute myeloid leukemia

Free
Johanna Rausch, Philipp Wendel, Viktor Fetsch, Marie Kuhmann, Lilian Viehböck, Fenja Gierschek, Najla Abassi, Margarita Dzama, Nadezda Dolgikh, Lea Knapp, Jan Habermann, Catharina Lahrmann, Ann-Katrin Gebel, Matthias Klein, Michael Delacher, Catherine Wölfel, Hakim Echchannaoui, Matthias Theobald, Daniel Sasca, Federico Marini, Robert Zeiser, Evelyn Ullrich, Michael Kühn
Journal: Blood
Blood (2025) 146 (Supplement 1): 866.
https://doi.org/10.1182/blood-2025-866
Published: 2025
Journal Articles

Synergistic Efficacy of Dual Menin and PRMT5 Targeting Against NPM1 mutated and KMT2A- rearranged Leukemia

Free
Nadezda Dolgikh, Johanna Rausch, Marlene Steiner, Jonas Schönfeld, Catharina Lahrmann, Nina Hilke, Maria Alejandra Vila Molerio, Simon Weisemann, Maria Saura-Pañella, Aarón Gallego-Crespo, Matthias Theobald, Daniel Sasca, Chun-Wei David Chen, Michael W.M. Kühn
Journal: Blood
Blood (2024) 144 (Supplement 1): 206.
https://doi.org/10.1182/blood-2024-202460
Published: 2024
Journal Articles

The Menin Inhibitor Ziftomenib (KO-539) Synergizes with Agents Targeting Chromatin Regulation or Apoptosis and Sensitizes AML with MLL Rearrangement or NPM1 Mutation to Venetoclax

Free
Johanna Rausch, Margarita M. Dzama, Nadezda Dolgikh, Hanna Stiller, Stephan Bohl, Catharina Lahrmann, Kerstin Kunz, Linda Kessler, Hakim Echchannaoui, Chun-Wei David Chen, Thomas Kindler, Francis Burrows, Matthias Theobald, Daniel Sasca, Scott A. Armstrong, Michael Kuehn
Journal: Blood
Blood (2022) 140 (Supplement 1): 6226–6227.
https://doi.org/10.1182/blood-2022-167566
Published: 2022
Journal Articles

Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition

Free
Margarita M. Dzama, Marlene Steiner, Johanna Rausch, Daniel Sasca, Jonas Schönfeld, Kerstin Kunz, Martha C. Taubert, Gerard M. McGeehan, Chun-Wei Chen, Annalisa Mupo, Patricia Hähnel, Matthias Theobald, Thomas Kindler, Richard P. Koche, George S. Vassiliou, Scott A. Armstrong, Michael W. M. Kühn
Journal: Blood
Blood (2020) 136 (21): 2442–2456.
https://doi.org/10.1182/blood.2020005037
Published: 2020
Includes: Supplemental data
Journal Articles

Combined Targeting of the Menin-MLL1 Chromatin Complex and FLT3 As a Novel Therapeutic Concept Against NPM1 Mutant or MLL -Rearranged AML with Mutated FLT3

Free
Margarita M. Dzama, MSc, Martha C. Taubert, MSc, Kerstin Kunz, Johanna Rausch, MD, Chun-Wei David Chen, PhD, Annalisa Mupo, PhD, Patricia Hähnel, PhD, Matthias Theobald, MD PhD, Thomas Kindler, MD, Richard P. Koche, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Scott A. Armstrong, MD PhD, Michael W.M. Kühn, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1441.
https://doi.org/10.1182/blood-2019-122847
Published: 2019