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Journal Articles

Medical and perioperative management of acute and subacute heparin-induced thrombocytopenia in adults requiring urgent cardiopulmonary bypass surgery.

Jimmy Lee, Allison M. Herzfeld, Maria Paz, Ming Lim, Grace Lee, Gowthami Arepally, Ian J. Welsby, Sean G. Yates, Taha Bat

Blood (2025) 146 (Supplement 1): 4889.

https://doi.org/10.1182/blood-2025-4889

Published: 2025

Journal Articles

HIT immune complexes activate the inflammasome pathway in a complement-dependent manner

James Michael, Sanjay Khandelwal, Antonios Tawk, Sophia Lazar, C. Garren Hester, Trenton Hiatt, Gowthami Arepally, Steven McKenzie

Blood (2025) 146 (Supplement 1): 3099.

https://doi.org/10.1182/blood-2025-3099

Published: 2025

Journal Articles

A Novel Adenovirus (Adv)-Vaccinated Murine Model Simulates the Prothrombotic Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) Clinical Disorder

Lubica Rauova, Jenna Oberg, Nate Levine, Khalil Bdeir, Douglas B. Cines, Sarah Gilbert, Mortimer Poncz, Gowthami Arepally

Blood (2023) 142 (Supplement 1): 2631.

https://doi.org/10.1182/blood-2023-186729

Published: 2023

Journal Articles

PIEZO1-TMEM16F Interplay in Hereditary Xerocytosis

Pengfei Liang, Yang Zhang, Yui Chun Serena Wan, Shang Ma, Ping Dong, Augustus Lowry, Samuel Francis, Sanjay Khandelwal, Martha Delahunty, Marilyn J. Telen, John J Strouse, Gowthami Arepally, Huanghe Yang

Blood (2023) 142 (Supplement 1): 3818.

https://doi.org/10.1182/blood-2023-178911

Published: 2023

Journal Articles

Transfusion-Dependent Anemia and Coagulopathy in a Porcine Model of Pediatric Extracorporeal Membrane Oxygenation (ECMO)

Christopher Robert Reed, MD, Desiree Bonadonna, MPS, Jeffrey R Everitt, DVM, Victoria Robinson, BA, James Otto, PhD, Gowthami Arepally, MD, Elisabeth T Tracy, MD

Blood (2019) 134 (Supplement_1): 1164.

https://doi.org/10.1182/blood-2019-124524

Published: 2019

Journal Articles

Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis

Kandace Gollomp, MD, Amrita Sarkar, PhD, Gowthami Arepally, MD, Douglas B. Cines, MD, M. Anna Kowalska, PhD, Lubica Rauova, MD PhD, Mortimer Poncz, MD

Blood (2019) 134 (Supplement_1): 10.

https://doi.org/10.1182/blood-2019-123132

Published: 2019

Journal Articles

Antibody Stabilization of Neutrophil Extracellular Trap-Platelet Factor 4 Complexes Is Therapeutic in a Murine Model of Endotoxemia

Amrita Sarkar, PhD, Gowthami Arepally, MD, M. Anna Kowalska, PhD, Douglas B. Cines, MD, Lubica Rauova, MD PhD, Mortimer Poncz, MD, Kandace Gollomp, MD

Blood (2018) 132 (Supplement 1): 271.

https://doi.org/10.1182/blood-2018-99-111381

Published: 2018

Journal Articles

In Vitro Complement Activation By PF4/Heparin Complexes Is Mediated By Plasma IgM

Sanjay Khandelwal, PhD, Lubica Rauova, MD PhD, Mortimer Poncz, MD, Michael Frank, MD, Douglas B. Cines, MD, Gowthami Arepally, MD

Blood (2017) 130 (Supplement 1): 3617.

https://doi.org/10.1182/blood.V130.Suppl_1.3617.3617

Published: 2017

Journal Articles

A Point-of-Care Quartz Biosensor Chip for Detection of PF4/Heparin Complexes

Jennifer Minjia Chang, Gowthami Arepally, MD, Stefan Zauscher, PhD, Zehra Parlak, PhD

Blood (2017) 130 (Supplement 1): 2327.

https://doi.org/10.1182/blood.V130.Suppl_1.2327.2327

Published: 2017

Journal Articles

Critical role for mouse marginal zone B cells in PF4/heparin antibody production

Yongwei Zheng, Mei Yu, Andrew Podd, Liudi Yuan, Debra K. Newman, Renren Wen, Gowthami Arepally, Demin Wang

Blood (2013) 121 (17): 3484–3492.

https://doi.org/10.1182/blood-2013-01-477091

Published: 2013

Journal Articles

Advantages wth Using the Levonorgestrel-Releasing Intrauterine System in Females with Hemostatic Disorders.

Andrea S. Lukes, MD, MHSc, Gowthami Arepally, MD

Blood (2006) 108 (11): 3303.

https://doi.org/10.1182/blood.V108.11.3303.3303

Published: 2006

Journal Articles

Immunoregulatory Mechanisms of PF4/Heparin Antibody Production In Vivo.

Gowthami Arepally, MD, Rui Qi, Shayela Suvarna, PhD

Blood (2006) 108 (11): 1050.

https://doi.org/10.1182/blood.V108.11.1050.1050

Published: 2006

Journal Articles

Dietary Hypercholesterolemia Enhances Heparin-Induced Thrombocytopenia/Thrombosis: A Prothrombotic Risk Factor in a Transgenic Mouse Model.

Michael P. Reilly, PhD, Scott K. Dessain, MD, PhD, Scott M. Taylor, MS, M. Anna Kowalska, PhD, Mortimer Poncz, MD, Bruce S. Sachais, MD, PhD, Douglas B. Cines, MD, Gowthami Arepally, MD, Kevin Jon Williams, MD, Steven E. McKenzie, MD, PhD

Blood (2005) 106 (11): 56.

https://doi.org/10.1182/blood.V106.11.56.56

Published: 2005

Journal Articles

PF4/heparin complexes are T cell–dependent antigens

Shayela Suvarna, Lubica Rauova, Emily K. E. McCracken, Christina M. Goss, Bruce S. Sachais, Steven E. McKenzie, Michael P. Reilly, Michael Dee Gunn, Douglas B. Cines, Mortimer Poncz, Gowthami Arepally

Blood (2005) 106 (3): 929–931.

https://doi.org/10.1182/blood-2004-12-4955

Published: 2005

Journal Articles

Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia

Lubica Rauova, Mortimer Poncz, Steven E. McKenzie, Michael P. Reilly, Gowthami Arepally, John W. Weisel, Chandrasekaran Nagaswami, Douglas B. Cines, Bruce S. Sachais

Blood (2005) 105 (1): 131–138.

https://doi.org/10.1182/blood-2004-04-1544

Published: 2005

Journal Articles

Players in the sandbox of childhood ITP

Gowthami Arepally

Blood (2004) 104 (7): 1916–1917.

https://doi.org/10.1182/blood-2004-07-2670

Published: 2004

Journal Articles

Evidence for Genetic Homogeneity in a Familial Platelet Disorder With Predisposition to Acute Myelogenous Leukemia (FPD/AML)

Gowthami Arepally, Timothy R. Rebbeck, Woojoo Song, Gary Gilliland, John M. Maris, Mortimer Poncz

Blood (1998) 92 (7): 2600–2602.

https://doi.org/10.1182/blood.V92.7.2600

Published: 1998

Journal Articles

FcγRIIA H/R 131 Polymorphism, Subclass-Specific IgG Anti-Heparin/Platelet Factor 4 Antibodies and Clinical Course in Patients With Heparin-Induced Thrombocytopenia and Thrombosis

Gowthami Arepally, Steven E. McKenzie, Xiao-Ming Jiang, Mortimer Poncz, Douglas B. Cines

Blood (1997) 89 (2): 370–375.

https://doi.org/10.1182/blood.V89.2.370

Published: 1997

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Medical and perioperative management of acute and subacute heparin-induced thrombocytopenia in adults requiring urgent cardiopulmonary bypass surgery.

HIT immune complexes activate the inflammasome pathway in a complement-dependent manner

A Novel Adenovirus (Adv)-Vaccinated Murine Model Simulates the Prothrombotic Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) Clinical Disorder

PIEZO1-TMEM16F Interplay in Hereditary Xerocytosis

Transfusion-Dependent Anemia and Coagulopathy in a Porcine Model of Pediatric Extracorporeal Membrane Oxygenation (ECMO)

Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis

Antibody Stabilization of Neutrophil Extracellular Trap-Platelet Factor 4 Complexes Is Therapeutic in a Murine Model of Endotoxemia

In Vitro Complement Activation By PF4/Heparin Complexes Is Mediated By Plasma IgM

A Point-of-Care Quartz Biosensor Chip for Detection of PF4/Heparin Complexes

Critical role for mouse marginal zone B cells in PF4/heparin antibody production

Advantages wth Using the Levonorgestrel-Releasing Intrauterine System in Females with Hemostatic Disorders.

Immunoregulatory Mechanisms of PF4/Heparin Antibody Production In Vivo.

Dietary Hypercholesterolemia Enhances Heparin-Induced Thrombocytopenia/Thrombosis: A Prothrombotic Risk Factor in a Transgenic Mouse Model.

PF4/heparin complexes are T cell–dependent antigens

Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia

Players in the sandbox of childhood ITP

Evidence for Genetic Homogeneity in a Familial Platelet Disorder With Predisposition to Acute Myelogenous Leukemia (FPD/AML)

FcγRIIA H/R 131 Polymorphism, Subclass-Specific IgG Anti-Heparin/Platelet Factor 4 Antibodies and Clinical Course in Patients With Heparin-Induced Thrombocytopenia and Thrombosis

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