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David Sermer
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Journal Articles

Surovatamig (AZD0486), a CD19xCD3 T-cell engager (TCE), demonstrates high rate of minimal residual disease (MRD)–Negative complete responses in Relapsed/Refractory (R/R) diffuse large B-cell lymphoma (DLBCL), including in patients who previously progressed on CD20 TCE and CD19 CAR T-cell therapies

Free
Tae Min Kim, Jing-Zhou Hou, Sameh Gaballa, Ranjit Nair, Dai Maruyama, Koji Izutsu, Sumana Devata, Dok Hyun Yoon, Won-Seog Kim, Yazeed Sawalha, Ryan Jacobs, Eliza Hawkes, Ming-Chung Wang, Constantine Tam, Don Stevens, Hisayuki Yokoyama, Jin Seok Kim, Matthew Matasar, Aravind Ramakrishnan, Denise Brennan, David Sermer, Robin Lesley, Xu (Sue) Zhu, Mihail Obrocea, Seok-Goo Cho
Journal: Blood
Blood (2025) 146 (Supplement 1): 5514.
https://doi.org/10.1182/blood-2025-5514
Published: 2025
Journal Articles

Integrated dissociated and spatial single-cell profiling reveals that HDAC inhibition restores anti-PD-1 sensitivity in Hodgkin lymphoma by disrupting monocyte-Hodgkin-reed-sternberg cell-driven immunosuppressive niches.

Free
Amira Marouf, Sneha Mitra, Robert Stuver, Nivetha Ganesan, Jahan Rahman, Alexander Boardman, Philip Caron, Tiffany Chang, Kevin David, Zachary Epstein-Peterson, Lorenzo Falchi, Paola Ghione, Paul Hamlin, Francisco Hernandez-Ilizaliturri, Steven Horwitz, Andrew Intlekofer, William Johnson, Reem Karmali, Jennifer Lue, Anita Kumar, Efrat Luttwak, Neena Mahajan, Ariela Noy, Colette Owens, Lia Palomba, Heiko Schoder, David Sermer, Venkatraman Seshan, Raphael Steiner, Pallawi Torka, Andrew Zelenetz, Gottfried von Keudell, Gilles Salles, Christina Leslie, Alison Moskowitz, Santosha Vardhana
Journal: Blood
Blood (2025) 146 (Supplement 1): 150.
https://doi.org/10.1182/blood-2025-150
Published: 2025
Journal Articles

Three-year follow-up of the Phase 1 first-in-human study investigating surovatamig, a novel CD19xCD3 T-cell engager, in patients with Relapsed/Refractory (R/R) follicular lymphoma (FL)

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Jing-Zhou Hou, Tae Min Kim, Seok-Goo Cho, Sameh Gaballa, Ranjit Nair, Koji Izutsu, Sumana Devata, Dok Hyun Yoon, Won-Seog Kim, Yazeed Sawalha, Ryan Jacobs, Eliza Hawkes, Ming-Chung Wang, Constantine Tam, Don Stevens, Hisayuki Yokoyama, Jin Seok Kim, Matthew Matasar, Aravind Ramakrishnan, Denise Brennan, David Sermer, Robin Lesley, Mihail Obrocea, Dai Maruyama
Journal: Blood
Blood (2025) 146 (Supplement 1): 1005.
https://doi.org/10.1182/blood-2025-1005
Published: 2025
Journal Articles

Exposure-Response Analysis and Quantitative Systems Pharmacology Modeling for Optimal RP2D Selection of AZD0486 in Follicular Lymphoma Patients

Free
Xu (Sue) Zhu, Damilola Olabode, Massimo Lai, Cesar Pichardo-Almarza, Kevin Smart, Denise Brennan, David Sermer, Robin Lesley
Journal: Blood
Blood (2024) 144 (Supplement 1): 2794.
https://doi.org/10.1182/blood-2024-197995
Published: 2024
Journal Articles

Final Response and Survival Results from a Phase II Trial of Pembrolizumab and Entinostat in Relapsed/Refractory Hodgkin Lymphoma

Free
Robert Stuver, Santosha A. Vardhana, Nivetha Ganesan, Alexander P. Boardman, Philip Caron, Tiffany Chang, Kevin A. David, Zachary D. Epstein-Peterson, Lorenzo Falchi, Paola Ghione, Paul A. Hamlin, Francisco Hernandez-Ilizaliturri, Steven Horwitz, Andrew M. Intlekofer, William T. Johnson, Reem Karmali, Jennifer Kimberly Lue, Anita Kumar, Efrat Luttwak, Neena Mahajan, Amira Marouf, Ariela Noy, Colette Owens, Maria Lia Palomba, Gilles Salles, Heiko Schoder, David Sermer, Venkatraman Seshan, Raphael E. Steiner, Pallawi Torka, Andrew D. Zelenetz, Gottfried von Keudell, Alison Moskowitz
Journal: Blood
Blood (2024) 144 (Supplement 1): 3053.
https://doi.org/10.1182/blood-2024-210053
Published: 2024
Journal Articles

Evaluation of AZD0486, a Novel CD19xCD3 T-Cell Engager, in Relapsed/Refractory Diffuse Large B-Cell Lymphoma in an Ongoing First-in-Human Phase 1 Study: High Complete Responses Seen in CAR-T-Naive and CAR-T-Exposed Patients

Free
Sameh Gaballa, Jing-Zhou Hou, Sumana Devata, Seok-Goo Cho, Ranjit Nair, Dok Hyun Yoon, Ryan Jacobs, Koji Izutsu, Don A. Stevens, Dai Maruyama, Constantine S. Tam, Yazeed Sawalha, Aravind Ramakrishnan, Matthew Matasar, Denise Brennan, Sue Zhu, Robin Lesley, Yasuhiro Oki, David Sermer, Tae Min Kim
Journal: Blood
Blood (2024) 144 (Supplement 1): 868.
https://doi.org/10.1182/blood-2024-193681
Published: 2024
Journal Articles

Escalating Doses of AZD0486, a Novel CD19xCD3 T-Cell Engager, Result in High Complete Remissions with Rapid Clearance of Minimal Residual Disease in Patients with Relapsed/Refractory Follicular Lymphoma

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Jing-Zhou Hou, Ranjit Nair, Ryan Jacobs, Tae Min Kim, Seok-Goo Cho, Dai Maruyama, Sumana Devata, Yazeed Sawalha, Dok Hyun Yoon, Constantine S. Tam, Koji Izutsu, Matthew Matasar, Don A. Stevens, Aravind Ramakrishnan, Denise Brennan, Xu Zhu, Robin Lesley, Yasuhiro Oki, David Sermer, Sameh Gaballa
Journal: Blood
Blood (2024) 144 (Supplement 1): 341.
https://doi.org/10.1182/blood-2024-193589
Published: 2024
Journal Articles

Ibrutinib and venetoclax as primary therapy in symptomatic, treatment-naïve Waldenström macroglobulinemia

Free
Clinical Trials & Observations
Jorge J. Castillo, Andrew R. Branagan, David Sermer, Catherine A. Flynn, Kirsten Meid, Megan Little, Katherine Stockman, Timothy White, Alexa Canning, Maria L. Guerrera, Amanda Kofides, Shirong Liu, Xia Liu, Kris Richardson, Nicholas Tsakmaklis, Christopher J. Patterson, Zachary R. Hunter, Steven P. Treon, Shayna Sarosiek
Journal: Blood
Blood (2024) 143 (7): 582–591.
https://doi.org/10.1182/blood.2023022420
Published: 2024
Includes: Supplemental data
Journal Articles

Double Step-up Dosing (2SUD) Regimen Mitigates Severe Icans and CRS While Maintaining High Efficacy in Subjects with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (NHL) Treated with AZD0486, a Novel CD19xCD3 T-Cell Engager (TCE): Updated Safety and Efficacy Data from the Ongoing First-in-Human (FIH) Phase 1 Trial

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Sameh Gaballa, Ranjit Nair, Ryan W Jacobs, Sumana Devata, Seok-Goo Cho, Don A. Stevens, Dok Hyun Yoon, Nirav N. Shah, Denise Brennan, Jason Law, Robert Chen, David Sermer, Robin Lesley, Ben Buelow, Alessandra Forcina, Jing-Zhou Hou
Journal: Blood
Blood (2023) 142 (Supplement 1): 1662.
https://doi.org/10.1182/blood-2023-174668
Published: 2023
Journal Articles

Clinical characteristics and outcomes of extranodal stage I diffuse large B-cell lymphoma in the rituximab era

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Sabela Bobillo, Erel Joffe, Jessica A. Lavery, David Sermer, Paola Ghione, Ariela Noy, Philip C. Caron, Audrey Hamilton, Paul A. Hamlin, Steven M. Horwitz, Anita Kumar, Matthew J. Matasar, Alison Moskowitz, Collette N. Owens, M. Lia Palomba, Connie L. Batlevi, David Straus, Gottfried von Keudell, Andrew D. Zelenetz, Joachim Yahalom, Ahmet Dogan, Venkatraman E. Seshan, Anas Younes
Journal: Blood
Blood (2021) 137 (1): 39–48.
https://doi.org/10.1182/blood.2020005112
Published: 2021
Includes: Supplemental data
Journal Articles

Central Nervous System Prophylaxis with High-Dose Intravenous Methotrexate or Intrathecal Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma and High-Risk of CNS Relapse Treated in the Rituximab Era

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Sabela Bobillo, MD, Erel Joffe, MDMSc, Venkatraman Seshan, PhD, Ariela Noy, MD, Steven M. Horwitz, MD, M. Lia Palomba, MD, Matthew J Matasar, MD, David J. Straus, MD, Paul A. Hamlin, MD, Connie Lee Batlevi, MD PhD, Paola Ghione, MD, David Sermer, MD, Alison J. Moskowitz, MD, Audrey Hamilton, MD, Philip Caron, MD PhD, Colette Owens, MD, Gottfried R. von Keudell, MD PhD, Ahmet Dogan, MD PhD, Andrew D. Zelenetz, MD PhD, Anas Younes, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1619.
https://doi.org/10.1182/blood-2019-131435
Published: 2019