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Journal Articles

S100A8/A9 drives T cell exhaustion and compromises the therapeutic efficacy of bispecific antibodies in multiple myeloma.

Free
Adolfo Aleman, Oliver Van Oekelen, Shriya Desai, Sidorela Reci, Leah Grossman, Rudra Prasad Dutta, Mathieu Desaunay, Junia Vieira, Rongbao Zhao, Rahul Sanawar, Mani Mohindru, Tarek Mouhieddine, Alessandro Lagana, Marta Larrayoz, Poulikos Poulikakos, Gurbakhash Kaur, Larysa Sanchez, Cesar Rodriguez Valdes, Santiago Thibaud, Adriana Rossi, Shambavi Richard, Joshua Richter, Hearn Cho, Jose A. Martinez-Climent, Amit Verma, Sundar Jagannath, Samir Parekh
Journal: Blood
Blood (2025) 146 (Supplement 1): 916.
https://doi.org/10.1182/blood-2025-916
Published: 2025
Journal Articles

Prolonged cytopenias after BCMA CAR‑T are associated with impaired endogenous T cell recovery characterized by decreased CD8+ T cell diversity

Free
Abigail Chutnik, Zachary Avigan, Ramy Mahmoud, Alessandro Lagana, Matthew Croken, Meenakshi Mehrotra, Zahra Moinfar, Adriana Rossi, Shambavi Richard, Gurbakhash Kaur, Joshua Richter, Larysa Sanchez, Cesar Rodriguez Valdes, Hearn Cho, Sundar Jagannath, Mesude Bicak, Nina Bhardwaj, Jane Houldsworth, Santiago Thibaud, Samir Parekh
Journal: Blood
Blood (2025) 146 (Supplement 1): 2290.
https://doi.org/10.1182/blood-2025-2290
Published: 2025
Journal Articles

Real world outcomes of bispecific T-cell engagers in plasma cell leukemia

Free
Mahmoud Gaballa, Kelley Julian, Aimaz Afrough, Doris Hansen, Utkarsh Goel, Andre De Menezes Silva Corraes, Danai Dima, Masooma Rana, Hitomi Hosoya, Lekha Mikkilineni, Lindsay Fogel, Shahzad Raza, Rahul Banerjee, Saurabh Zanwar, Oren Pasvolsky, Aishwarya Sannareddy, Azra Borogovac, James Davis, Kimberly Green, Noa Biran, Megan Herr, Leyla Shune, Evguenia Bhurtel, Shebli Atrash, Christopher Ferreri, Tiffany Richards, Muhammad Bilal Abid, Susan Bal, Hossam M. Ali, J Christine Ye, Shambavi Richard, Gurbakhash Kaur, Kenneth Shain, Omar Alexis Castaneda Puglianini, Adriana Rossi, Larry Anderson, Peter Voorhees, Jack Khouri, Surbhi Sidana, Andrew Portuguese, Murali Janakiram, Hans Lee, Yi Lin, Ariel Grajales-Cruz, Krina Patel, Douglas Sborov
Journal: Blood
Blood (2025) 146 (Supplement 1): 823.
https://doi.org/10.1182/blood-2025-823
Published: 2025
Journal Articles

Spatially resolved transcriptomics reveals immunosuppressive niches and clonal diversity in extramedullary disease in multiple myeloma refractory to immunotherapy

Free
Junia Vieira, Reyka Jayasinghe, Tarek Mouhieddine, Jordan Lu, Hajer Merarda, Darwin D'Souza, Hyo Jeong Nam, Adolfo Aleman, Meghana Ram, Zhihong Chen, Seunghee Kim-Schulze, Gaurav Bhatt, Julie Fortier, Michael Slade, Alina Dulau Florea, Rachel Brody, Larysa Sanchez, Cesar Rodriguez Valdes, Joshua Richter, Shambavi Richard, Adriana Rossi, Sundar Jagannath, Ravi Vij, Li Ding, Samir Parekh, Alessandro Lagana
Journal: Blood
Blood (2025) 146 (Supplement 1): 3949.
https://doi.org/10.1182/blood-2025-3949
Published: 2025
Journal Articles

Shared immune features correspond to high-risk multiple myeloma across multiple human subtypes and murine models

Free
Junia Vieira, Fnu Nabuqi, Alison Park, Alessia D'Anna, Tarek Mouhieddine, Kiana Chen, Erik Guillen, Roshan Mathews, Gregoire Lauvau, Jing Zhang, Katerina Kappes, Rudra Prasad Dutta, Julie Fortier, Chad Bjorklund, Michael Amatangelo, Anita Gandhi, Zhihong Chen, Seunghee Kim-Schulze, Michael Slade, Udo Oppermann, Rena Feinman, Santiago Thibaud, Joshua Richter, Shambavi Richard, Cesar Rodriguez Valdes, Adriana Rossi, Hearn Cho, Fotios Asimakopoulos, David Siegel, Ravi Vij, Sundar Jagannath, Samir Parekh, David Fooksman, Alessandro Lagana
Journal: Blood
Blood (2025) 146 (Supplement 1): 5723.
https://doi.org/10.1182/blood-2025-5723
Published: 2025
Journal Articles

Impact of antibiotic timing on survival outcomes in CD19 and BCMA CAR-T cell therapy

Free
Serena Tharakan, Patrick Crorkin, Sana Ahmad, Jana Mihalyova, Shivani Handa, Jacques Azzi, Adriana Rossi, Shambavi Richard, Sundar Jagannath, Keren Osman, Alla Keyzner, Uroosa Ibrahim
Journal: Blood
Blood (2025) 146 (Supplement 1): 4113.
https://doi.org/10.1182/blood-2025-4113
Published: 2025
Journal Articles

Impact of short-form, case-based continuing medical education on clinician knowledge and competence in optimizing CAR T-cell therapy for Relapsed/Refractory multiple myeloma

Free
Meghan Coulehan, Aisha Suhail, Emily Kitterman, Jesús Berdeja, Adriana Rossi
Journal: Blood
Blood (2025) 146 (Supplement 1): 8220.
https://doi.org/10.1182/blood-2025-8220
Published: 2025
Journal Articles

Development of predictive relapse indicators for myeloma T cell engagers (PRIME) model for myeloma patients receiving BCMA- and GPRC5D-targeting T cell engagers

Free
Tarek Mouhieddine, Tianxiang Sheng, Junia Vieira, Adolfo Aleman, Zachary Avigan, Ariel Siegel, Mujahid Quidwai, Jordan Lu, Mohammad Rattu, Santiago Thibaud, Gurbakhash Kaur, Shambavi Richard, Adriana Rossi, Hearn Cho, Alessandro Lagana, Samantha Stclair, Dalia Abdel Azim, Larysa Sanchez, Joshua Richter, Cesar Rodriguez Valdes, Christian Salib, Erin Moshier, Samir Parekh, Sundar Jagannath
Journal: Blood
Blood (2025) 146 (Supplement 1): 3996.
https://doi.org/10.1182/blood-2025-3996
Published: 2025
Journal Articles

Combined PD-1 and Tim-3 Blockade Improves the in Vitro Anti-Myeloma Activity of T Cells of Patients on Talquetamab

Free
Tarek H. Mouhieddine, Junia Vieira, Adolfo Aleman, Leah Grossman, David Melnekoff, Bhaskar Upadhyaya, Samantha St. Clair, Monica Garcia-Barros, Meghana Ram, Santiago Thibaud, Adriana Rossi, Shambavi Richard, Cesar Rodriguez, Joshua Richter, Hearn Jay Cho, Larysa Sanchez, Sundar Jagannath, Ajai Chari, Rachel Brody, Christian Salib, Alessandro Lagana, Samir Parekh
Journal: Blood
Blood (2024) 144 (Supplement 1): 357.
https://doi.org/10.1182/blood-2024-204929
Published: 2024
Journal Articles

Delayed Neutrophil Recovery Following BCMA-Directed CAR-T Correlates with Poor Outcomes and Is Associated with a Cytokine Signature of Persistent Inflammation and T Cell Checkpoint Activation

Free
Zachary M Avigan, Saoirse Bodnar, Darren Pan, Adolfo Aleman, Joshua Richter, Larysa J Sanchez, Cesar Rodriguez, Adriana Rossi, Shambavi Richard, Hearn Jay Cho, Sundar Jagannath, Samir Parekh, Santiago Thibaud
Journal: Blood
Blood (2024) 144 (Supplement 1): 3329.
https://doi.org/10.1182/blood-2024-202725
Published: 2024
Journal Articles

A Phase 2 Study of Daratumumab in Combination with Dose-Attenuated Bortezomib, Lenalidomide, and Dexamethasone in Transplant Ineligible Older Adults with Newly Diagnosed Multiple Myeloma

Free
Larysa J Sanchez, Erin Moshier, Alex Lieberman-Cribbin, Joshua Richter, Shambavi Richard, Adriana Rossi, Cesar Rodriguez, Santiago Thibaud, Hearn Jay Cho, Samir Parekh, Sundar Jagannath, Ajai Chari
Journal: Blood
Blood (2024) 144 (Supplement 1): 7043.
https://doi.org/10.1182/blood-2024-211704
Published: 2024
Journal Articles

BMS-986393, a G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D)-Targeted CAR T Cell Therapy, in Patients (pts) with Relapsed/Refractory (RR) Multiple Myeloma (MM) and 1-3 Prior Regimens: Updated Phase 1 Safety and Efficacy Results

Free
Susan Bal, Myo Htut, Jesús G. Berdeja, Larry D Anderson, Jr., Adriana Rossi, Tara Gregory, Thomas G Martin, Luciano J. Costa, Hongxiang Hu, Jinjie Chen, Chaoqun Mei, Naomey Sarkis, Alok Shrestha, Safiyyah Ziyad, Wei-Ming Kao, Allison J Kaeding, Michael R. Burgess, Omar Nadeem
Journal: Blood
Blood (2024) 144 (Supplement 1): 2069.
https://doi.org/10.1182/blood-2024-203279
Published: 2024
Journal Articles

Outcomes of Teclistamab (Tec) in Patients with Relapsed/Refractory Multiple Myeloma (RRMM) with Prior Exposure to BCMA-Directed Therapy (BCMA-DT): A Multicenter Study from the U.S. Multiple Myeloma Immunotherapy Consortium

Free
Danai Dima, Mariola A Vazquez-Martinez, James A Davis, Utkarsh Goel, Aimaz Afrough, Aishwarya Sannareddy, Oren Pasvolsky, Beatrice Razzo, Rahul Banerjee, Jack Khouri, Ariel Grajales-Cruz, Alex Lieberman-Cribbin, Masooma Shifa Rana, Kelley Julian, Shaun DeJarnette, Andrew J Portuguese, Mahmoud R. Gaballa, Gabriel De Avila, Sandra Susanibar-Adaniya, Shahzad Raza, Megan M Herr, Evguenia Ouchveridze, Tiffany Richards, Hitomi Hosoya, Lekha Mikkilineni, Gurbakhash Kaur, Daniel Schrum, Omar Castaneda, Adriana Rossi, Chenyu Lin, Peter A. Forsberg, Yi Lin, Shebli Atrash, Douglas W Sborov, Kenneth H. Shain, Peter M. Voorhees, Shambavi Richard, Alfred L. Garfall, Doris K. Hansen, Surbhi Sidana, Krina K. Patel, Andrew J. Cowan, Larry D Anderson, Jr., Hans C. Lee, Faiz Anwer, Christopher Ferreri, Leyla O. Shune
Journal: Blood
Blood (2024) 144 (Supplement 1): 897.
https://doi.org/10.1182/blood-2024-203409
Published: 2024
Journal Articles

Efficacy and Safety with Extended Follow-up in a Phase 1 Study of BMS-986393, a G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D)-Targeted CAR T Cell Therapy, in Patients (pts) with Heavily Pretreated Relapsed/Refractory (RR) Multiple Myeloma (MM)

Free
Susan Bal, Larry D Anderson, Jr., Omar Nadeem, Jesús G. Berdeja, Adriana Rossi, Tara Gregory, Mehmet Hakan Koçoğlu, Thomas G Martin, Daniel N. Egan, Luciano J. Costa, Hongxiang Hu, Jinjie Chen, Chaoqun Mei, Naomey Sarkis, Alok Shrestha, Safiyyah Ziyad, Wei-Ming Kao, Allison J Kaeding, Michael R. Burgess, Myo Htut
Journal: Blood
Blood (2024) 144 (Supplement 1): 922.
https://doi.org/10.1182/blood-2024-201356
Published: 2024
Journal Articles

Outcomes of Elderly Patients with Relapsed Refractory Multiple Myeloma (RRMM) Treated with Teclistamab: A Multicenter Study from the U.S. Multiple Myeloma Immunotherapy Consortium

Free
Oren Pasvolsky, Danai Dima, Lei Feng, Wenli Dong, Tiffany Richards, James A Davis, Aimaz Afrough, Mariola A Vazquez-Martinez, Aishwarya Sannareddy, Utkarsh Goel, Rahul Banerjee, Jack Khouri, Frances N. Cervoni Curet, Mahmoud R. Gaballa, Alex Lieberman-Cribbin, Masooma S Rana, Kelley Julian, Christopher J Ferreri, Leyla O. Shune, Shaun DeJarnette, Evguenia Ouchveridze, Sandra Susanibar-Adaniya, Andrew J. Portuguese, Hitomi Hosoya, Lekha Mikkilineni, Gurbakhash Kaur, Adriana Rossi, Megan M Herr, Daniel Schrum, Chenyu Lin, Shahzad Raza, Yi Lin, Shebli Atrash, Joseph P. McGuirk, Douglas W Sborov, Peter M. Voorhees, Faiz Anwer, Melissa Alsina, Ciara Louise Freeman, Alfred L. Garfall, Surbhi Sidana, Andrew J. Cowan, Larry D Anderson, Jr., Doris K. Hansen, Shambavi Richard, Krina K. Patel, Hans C. Lee, Ariel Grajales-Cruz
Journal: Blood
Blood (2024) 144 (Supplement 1): 934.
https://doi.org/10.1182/blood-2024-205989
Published: 2024
Journal Articles

Enhanced Detection of Pathogenic Germline Variants in Plasma Cell Disorders: Impact of a Targeted Genetic Counseling Referral Pathway

Free
Saoirse Bodnar, Tehilla Brander, Zachary M Avigan, William Genthe, David Melnekoff, Alessandro Lagana, Jane Houldsworth, Shambavi Richard, Joshua Richter, Larysa J Sanchez, Cesar Rodriguez, Adriana Rossi, Hearn Jay Cho, Kenan Onel, Sundar Jagannath, Manisha Balwani, Samir Parekh, Santiago Thibaud
Journal: Blood
Blood (2024) 144 (Supplement 1): 1970.
https://doi.org/10.1182/blood-2024-212204
Published: 2024
Journal Articles

Predictors and Characterization of Cytokine Release Syndrome (CRS) and Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) in Patients with Multiple Myeloma Receiving Teclistamab

Free
Oren Pasvolsky, Aimaz Afrough, Lei Feng, Wenli Dong, Tiffany Richards, James A Davis, Danai Dima, Ariel Grajales-Cruz, Mariola A Vazquez-Martinez, Aishwarya Sannareddy, Utkarsh Goel, Rahul Banerjee, Mahmoud R. Gaballa, Alex Lieberman-Cribbin, Masooma S Rana, Kelley Julian, Christopher J Ferreri, Leyla O. Shune, Shaun DeJarnette, Evguenia Ouchveridze, Sandra Susanibar-Adaniya, Andrew J. Portuguese, Peter A. Forsberg, Hitomi Hosoya, Lekha Mikkilineni, Gurbakhash Kaur, Adriana Rossi, Megan M Herr, Erin Eberwein, Chenyu Lin, Brandon Blue, Shahzad Raza, Yi Lin, Joseph P. McGuirk, Shebli Atrash, Douglas W Sborov, Peter M. Voorhees, Faiz Anwer, Doris K. Hansen, Krina K. Patel, Surbhi Sidana, Andrew J. Cowan, Larry D Anderson, Jr., Shambavi Richard, Alfred L. Garfall, Hans C. Lee, Jack Khouri
Journal: Blood
Blood (2024) 144 (Supplement 1): 3337.
https://doi.org/10.1182/blood-2024-206357
Published: 2024
Journal Articles

Interventions and outcomes of patients with multiple myeloma receiving salvage therapy after BCMA-directed CAR T therapy

Free
Clinical Trials & Observations
Oliver Van Oekelen, Karthik Nath, Tarek H. Mouhieddine, Tasmin Farzana, Adolfo Aleman, David T. Melnekoff, Yogita Ghodke-Puranik, Gunjan L. Shah, Alexander Lesokhin, Sergio Giralt, Santiago Thibaud, Adriana Rossi, Cesar Rodriguez, Larysa Sanchez, Joshua Richter, Shambavi Richard, Hearn J. Cho, Ajai Chari, Saad Z. Usmani, Sundar Jagannath, Urvi A. Shah, Sham Mailankody, Samir Parekh
Journal: Blood
Blood (2023) 141 (7): 756–765.
https://doi.org/10.1182/blood.2022017848
Published: 2023
Includes: Supplemental data
Journal Articles

Extramedullary Relapse Post CAR-T

Free
Shambavi Richard, Guido Lancman, Adriana Rossi, Ajai Chari, Samir Parekh, Larysa Sanchez, Cesar Rodriguez, Hearn J. Cho, Joshua Richter, Santiago Thibaud, Kiah Purcell, Elizabeth Aronson, Daniel Verina, Juliet Escalon, Karen Louw, Sundar Jagannath
Journal: Blood
Blood (2022) 140 (Supplement 1): 4301–4302.
https://doi.org/10.1182/blood-2022-170119
Published: 2022
Journal Articles

Gain of chr1q Portends Poor Outcomes in Multiple Myeloma Patients Treated with Venetoclax

Free
Alessandro Lagana, Santiago Thibaud, David T. Melnekoff, Paula Restrepo, Violetta Leshchenko, Jonathan McCafferty, Scott Newman, Abbi Kern, David Corrigan, Feras Hantash, Adriana Rossi, Cesar Rodriguez, Larysa Sanchez, Shambavi Richard, Ajai Chari, Hearn J. Cho, Sundar Jagannath, Joshua Richter, Samir Parekh
Journal: Blood
Blood (2022) 140 (Supplement 1): 4388–4390.
https://doi.org/10.1182/blood-2022-166572
Published: 2022