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Journal Articles

MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

Melanie Demers, PhD, Sarah Sturtevant, BSc, Kevin Guertin, PhD, Dipti Gupta, Kunal Desai, MS, Benjamin Vieira, BS, Alexandra Hicks, PhD, Ayman Ismail, PhD, Yukio Nakamura, MD PhD, Bronner Goncalves, MD PhD, Giuseppe Di Caprio, PhD, Ethan Schonbrun, PhD, Scott Hansen, BS, Martin K. Safo, PhD, David K. Wood, PhD, John M. Higgins, MD PhD, David R. Light, PhD

Blood (2019) 134 (Supplement_1): 2260.

https://doi.org/10.1182/blood-2019-128727

Published: 2019

Journal Articles

TJC4, a Differentiated Anti-CD47 Antibody with Novel Epitope and RBC Sparing Properties

Zhen Meng, PhD, Zhengyi Wang, PhD, Bingshi Guo, PhD, Wei Cao, PhD, Huaqiong Shen, MD PhD

Blood (2019) 134 (Supplement_1): 4063.

https://doi.org/10.1182/blood-2019-122793

Published: 2019

Journal Articles

Characterization of Recombinant β2GPI Using Hydrogen-Deuterium Exchange and X-Ray Crystallography

Ravi Kumar Alluri, PhD, Nicholas Arce, Philip Klenotic, Chih Chia Su, PhD, Suman Kundu, MBA, Edward Yu, PhD, Renhao Li, PhD, Keith R McCrae, MD

Blood (2019) 134 (Supplement_1): 1105.

https://doi.org/10.1182/blood-2019-131386

Published: 2019

Journal Articles

Anticancer Activity of a Highly Potent Small Molecule Tubulin Polymerization Inhibitor, AB8939

Martine Humbert, PhD, Armelle Goubard, PhD, Colin Mansfield, PhD, Olivier Hermine, MD PhD, Patrice Dubreuil, PhD, The AB8939 Study Group

Blood (2019) 134 (Supplement_1): 2075.

https://doi.org/10.1182/blood-2019-122540

Published: 2019

Journal Articles

Comparison of the Profile of the AML Drug Midostaurin (Rydapt®) As a Kinase Inhibitor with Those of Its Predominant Primary Human Metabolites

Paul W Manley, Giorgio Caravatti, Pascal Furet, Johannes Roesel, Phi Tran, Trixie Wagner

Blood (2017) 130 (Supplement 1): 1383.

https://doi.org/10.1182/blood.V130.Suppl_1.1383.1383

Published: 2017

Journal Articles

Quantitative Structural Characterization of Fibrinogen's αC Regions in Fibrin Monomers and Oligomers

Anna D. Protopopova, PhD, Rustem I. Litvinov, MD PhD, Dmitry V. Klinov, PhD, Dennis K. Galanakis, MD, John W. Weisel, PhD

Blood (2017) 130 (Supplement 1): 1056.

https://doi.org/10.1182/blood.V130.Suppl_1.1056.1056

Published: 2017

Journal Articles

Extrinsic Complex Structure Developed through Novel Simulation Methodology: Key Putative Atomic-Level Interactions Identified

Melanie Muller, BS, Emad Tajkhorshid

Blood (2017) 130 (Supplement 1): 1065.

https://doi.org/10.1182/blood.V130.Suppl_1.1065.1065

Published: 2017

Journal Articles

Comprehensive Analysis of the Structural, Biochemical and Signaling Differences of the p210 and p185 Isoforms of Bcr-Abl in CML and B-ALL

Oliver Hantschel, PhD, Sina Reckel, Hamelin Romain, Florence Armand, Delphine Harduin, Shohei Koide, Volker Dötsch, Marc Moniatte

Blood (2016) 128 (22): 4238.

https://doi.org/10.1182/blood.V128.22.4238.4238

Published: 2016

Journal Articles

Novel Structurally-Modified Allosteric Effectors of Hemoglobin Exhibit Superior Antisickling Properties

Osheiza Abdulmalik, DVM, MS, Tanvi Deshpande, MS, Mohini Ghatge, PhD, Yan Zhang, PhD, Jurgen Venitz, MDPhD, Apurvasena Parikh, PhD, Martin K. Safo, PhD

Blood (2014) 124 (21): 218.

https://doi.org/10.1182/blood.V124.21.218.218

Published: 2014

Journal Articles

ABL001, a Potent Allosteric Inhibitor of BCR-ABL, Prevents Emergence of Resistant Disease When Administered in Combination with Nilotinib in an in Vivo Murine Model of Chronic Myeloid Leukemia

Blood (2014) 124 (21): 398.

https://doi.org/10.1182/blood.V124.21.398.398

Published: 2014

Journal Articles

Structural Studies Of The Factor VIII C2 Domain In a Ternary Complex With Two Inhibitory Antibodies Reveals Classical and Non-Classical Epitopes

Justin D Walter, M.S., Rachel A Werther, M.S., Caileen M Brison, B.S., John F. Healey, B.S., Shannon L. Meeks, MD, John (Pete) S. Lollar, III, MD, P. Clint Spiegel, Jr., Ph.D.

Blood (2013) 122 (21): 2358.

https://doi.org/10.1182/blood.V122.21.2358.2358

Published: 2013

Journal Articles

Structure-Guided Design of A Novel High Affinity Integrin αIIbβ3 Receptor Antagonist (RUC-2) That Displaces Mg 2+ From the β3 MIDAS,

Jieqing Zhu, PhD, Won-Seok Choi, PhD, Joshua G. McCoy, BS, MS, Ana Negri, PhD, Jianghai Zhu, PhD, Sarasija Naini, BS, MS, Jihong Li, MD, Min Shen, PhD, Wenwei Huang, PhD, Craig J. Thomas, PhD, Marta Filizola, PhD, Timothy Springer, PhD, Barry S. Coller, MD

Blood (2011) 118 (21): 3255.

https://doi.org/10.1182/blood.V118.21.3255.3255

Published: 2011

Journal Articles

Crystal Structure Analysis Reveals That the Novel Type II Anti-CD20 Antibody GA101 Interacts with a Similar Epitope as Rituximab and Ocrelizumab but in a Fundamentally Different Way.

Gerhard J Niederfellner, Alfred Lammens, Manfred Schwaiger, Guy Georges, Kornelius Wiechmann, Andreas Franke, Wolfgang Schaefer, Stefan Jenewein, Jerry Slootstra, Ekkehard Moessner, Pablo Umana, Karl-Peter Hopfner, Christian Klein

Blood (2009) 114 (22): 3726.

https://doi.org/10.1182/blood.V114.22.3726.3726

Published: 2009

Journal Articles

Immune Targeting of the Phosphoproteome in Lymphoma and Leukemia.

Mark Cobbold, MD, PhD, Joy M. Polefrone, PhD, Jie Qian, Fiyaz Mohammed, PhD, Andrew Norris, Andrea M. De Santis, Angela L. Zarling, PhD, Jeffery Shabanowitz, PhD, Benjamin E. Willcox, PhD, Michael E. Williams, MD, Donald F. Hunt, PhD, Victor H. Engelhard, PhD

Blood (2007) 110 (11): 285.

https://doi.org/10.1182/blood.V110.11.285.285

Published: 2007

Journal Articles

Design and Development of Small Molecules for Specific Targeted Therapy of Diffuse Large B-Cell Lymphoma.

Gustavo F. Da Silva, MS, Alex Ghetu, PhD, Leandro Cerchietti, MD, Jose M. Polo, MS, Andrew Coop, PhD, Alexander Mackerell, PhD, Gilbert G. Prive, PhD, Ari Melnick, MD

Blood (2007) 110 (11): 799.

https://doi.org/10.1182/blood.V110.11.799.799

Published: 2007

Journal Articles

The Laminin 511/521–binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3

Tosti J. Mankelow, Nicholas Burton, Fanney O. Stefansdottir, Frances A. Spring, Stephen F. Parsons, Jan S. Pedersen, Cristiano L. P. Oliveira, Donna Lammie, Timothy Wess, Narla Mohandas, Joel Anne Chasis, R. Leo Brady, David J. Anstee

Blood (2007) 110 (9): 3398–3406.

https://doi.org/10.1182/blood-2007-06-094748

Published: 2007

Includes: Supplemental data

Journal Articles

Forced Expression of the “IY” Mutant Inosine Monophosphate Dehydrogenase II Results in Physiologically Significant Resistance to Mycophenolic Acid In Vitro.

Mark A. Schroeder, MD, John F. DiPersio, MD/PhD, Michael P. Rettig, PhD, Julie K. Ritchey

Blood (2006) 108 (11): 5480.

https://doi.org/10.1182/blood.V108.11.5480.5480

Published: 2006

Journal Articles

Inosine Monophosphate Dehydrogenase II Mutant (Thr-333-Ile + Ser-351-Tyr) Does Not Confer Resistance to Mycophenolic Acid In Vivo.

Mark A. Schroeder, MD, Michael P. Rettig, PhD, Julie K. Ritchey, John F. DiPersio, MD, PhD

Blood (2005) 106 (11): 5226.

https://doi.org/10.1182/blood.V106.11.5226.5226

Published: 2005

Journal Articles

A Novel Heterologous Expression System for Characterization of Individual NADH-Cytochrome b 5 Reductase Variants in Recessive Congenital Methemoglobinemia.

Melanie J. Percy, PhD, L. J. Crowley, PhD, C. A. Davis, PhD, J. Boudreaux, MD, D. M. Layton, MD, M. F. McMullin, MD, T. R. Lappin, PhD, M. J. Barber, DPhil

Blood (2005) 106 (11): 1676.

https://doi.org/10.1182/blood.V106.11.1676.1676

Published: 2005

Journal Articles

X-Ray Cristallography Characterization of Human CD44 Epitopes Releasing Differentiation Blockage in Acute Myeloid Leukemia Blasts.

Nicolas Lecomte, Laetitia Durand, Alberto Roseto, PhD, Christine Chomienne, MD, Jean Kadouche, PhD, Florence Smadja-Joffe, PhD

Blood (2005) 106 (11): 4433.

https://doi.org/10.1182/blood.V106.11.4433.4433

Published: 2005

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MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

TJC4, a Differentiated Anti-CD47 Antibody with Novel Epitope and RBC Sparing Properties

Characterization of Recombinant β2GPI Using Hydrogen-Deuterium Exchange and X-Ray Crystallography

Anticancer Activity of a Highly Potent Small Molecule Tubulin Polymerization Inhibitor, AB8939

Comparison of the Profile of the AML Drug Midostaurin (Rydapt®) As a Kinase Inhibitor with Those of Its Predominant Primary Human Metabolites

Quantitative Structural Characterization of Fibrinogen's αC Regions in Fibrin Monomers and Oligomers

Extrinsic Complex Structure Developed through Novel Simulation Methodology: Key Putative Atomic-Level Interactions Identified

Comprehensive Analysis of the Structural, Biochemical and Signaling Differences of the p210 and p185 Isoforms of Bcr-Abl in CML and B-ALL

Novel Structurally-Modified Allosteric Effectors of Hemoglobin Exhibit Superior Antisickling Properties

ABL001, a Potent Allosteric Inhibitor of BCR-ABL, Prevents Emergence of Resistant Disease When Administered in Combination with Nilotinib in an in Vivo Murine Model of Chronic Myeloid Leukemia

Structural Studies Of The Factor VIII C2 Domain In a Ternary Complex With Two Inhibitory Antibodies Reveals Classical and Non-Classical Epitopes

Structure-Guided Design of A Novel High Affinity Integrin αIIbβ3 Receptor Antagonist (RUC-2) That Displaces Mg 2+ From the β3 MIDAS,

Crystal Structure Analysis Reveals That the Novel Type II Anti-CD20 Antibody GA101 Interacts with a Similar Epitope as Rituximab and Ocrelizumab but in a Fundamentally Different Way.

Immune Targeting of the Phosphoproteome in Lymphoma and Leukemia.

Design and Development of Small Molecules for Specific Targeted Therapy of Diffuse Large B-Cell Lymphoma.

The Laminin 511/521–binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3

Forced Expression of the “IY” Mutant Inosine Monophosphate Dehydrogenase II Results in Physiologically Significant Resistance to Mycophenolic Acid In Vitro.

Inosine Monophosphate Dehydrogenase II Mutant (Thr-333-Ile + Ser-351-Tyr) Does Not Confer Resistance to Mycophenolic Acid In Vivo.

A Novel Heterologous Expression System for Characterization of Individual NADH-Cytochrome b 5 Reductase Variants in Recessive Congenital Methemoglobinemia.

X-Ray Cristallography Characterization of Human CD44 Epitopes Releasing Differentiation Blockage in Acute Myeloid Leukemia Blasts.

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