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Ryan P Larson
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Journal Articles

Nonclinical Toxicology, Biodistribution, and Pharmacokinetics of UB-VV111, an In Vivo Anti-CD19 CAR T Cell Therapy

Free
Alissa H. Brandes, Angela Soo Min Koo, Anai Perez, Kathryn Michels, Travis Friesen, Alyssa Sheih, Don Parilla, Susana Hernandez, Nolan Ericson, Sarah Dickerson, Mason Muhonen, Jessica Freeman, Sarah Gould, Alessandra Maria Sullivan, Jeffrey Teoh, Byoung Y. Ryu, Andrew M. Scharenberg, Ryan P. Larson
Journal: Blood
Blood (2024) 144 (Supplement 1): 2046.
https://doi.org/10.1182/blood-2024-211032
Published: 2024
Journal Articles

A Synthetic Receptor Enables Breakthrough Scale Manufacturing of iPSC-Derived CD19-CAR Cell Therapies for Hematologic and Autoimmune Diseases

Free
Dillon Jarrell, David Vereide, Cassidy Arnold, Max Murphey, Ashley Yingst, Ryan Koning, Nikole Perdue, Artem Romanov, Celeste Busch, Igor Slukvin, Ryan Crisman, Ryan P. Larson, Andrew M. Scharenberg, Branden Salinas, Samantha Ohara
Journal: Blood
Blood (2024) 144 (Supplement 1): 148.
https://doi.org/10.1182/blood-2024-200130
Published: 2024
Journal Articles

Vivovec™ Surface-Engineered Lentiviral Particles Mediate In Vivo CAR T Generation with Potent and Highly Durable Activity in Non-Human Primates

Free
Maura H. Parker, Kristen L. Mittelsteadt, Justin T. Ulrich-Lewis, Weiliang Tang, Mollie M. McDonnell, Richard Manivanh, Alissa H. Brandes, Nolan Ericson, Angela Soo Min Koo, Greyson Hamilton, Yong Ha Youn, Chang-Chih Wu, Seungjin Shin, Rebecca J Gottschalk, Kelsey L Lynch, Eric Cavanaugh, Hans-Peter Kiem, Andrew M. Scharenberg, Ryan P. Larson, Laurie O. Beitz, Byoung Y. Ryu
Journal: Blood
Blood (2024) 144 (Supplement 1): 502.
https://doi.org/10.1182/blood-2024-206328
Published: 2024
Journal Articles

In vivo CAR T-cell generation in nonhuman primates using lentiviral vectors displaying a multidomain fusion ligand

Free
Christopher J. Nicolai, Maura H. Parker, Jim Qin, Weiliang Tang, Justin T. Ulrich-Lewis, Rebecca J. Gottschalk, Sara E. Cooper, Susana A. Hernandez Lopez, Don Parrilla, Richard S. Mangio, Nolan G. Ericson, Alissa H. Brandes, Saluwa Umuhoza, Kathryn R. Michels, Mollie M. McDonnell, Lisa Y. Park, Seungjin Shin, Wai-Hang Leung, Andrew M. Scharenberg, Hans-Peter Kiem, Ryan P. Larson, Laurie O. Beitz, Byoung Y. Ryu
Journal: Blood
Blood (2024) 144 (9): 977–987.
https://doi.org/10.1182/blood.2024024523
Published: 2024
Includes: Supplemental data
Journal Articles

Vivovec™ Surface-Engineered Lentiviral Particles Mediate In Vivo CAR T Generation with Potent and Highly Durable Activity in Non-Human Primates and Tumor-Bearing Humanized Mice

Free
Maura Parker, Justin Ulrich-Lewis, Weiliang Tang, Chris Nicolai, Kathryn Michels, Susana Hernandez, Don Parrilla, Sara Cooper, Anai Perez, Mollie McDonnell, Greyson Hamilton, Chang-Chih Wu, Seungjin Shin, Andrew M. Scharenberg, Ryan P. Larson, Laurie Beitz, Byoung Y. Ryu
Journal: Blood
Blood (2023) 142 (Supplement 1): 765.
https://doi.org/10.1182/blood-2023-182195
Published: 2023
Journal Articles

Statistical Learning Approaches for Predicting Lisocabtagene Maraleucel (liso-cel) Drug Product Composition from Donor-Selected Material Composition

Free
Yue Jiang, PhD, Afshin Mashadi-Hossein, MSc, Rachel Yost, Jeffrey Teoh, PhD, Ryan P. Larson, PhD, Ronald J. Hause, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 591.
https://doi.org/10.1182/blood-2019-125801
Published: 2019
Journal Articles

Lisocabtagene Maraleucel (liso-cel) Manufacturing Process Control and Robustness across CD19+ Hematological Malignancies

Free
Jeffrey Teoh, PhD, Timothy G. Johnstone, PhD, Brian Christin, BS, Rachel Yost, Neil A. Haig, Mary Mallaney, Aditya Radhakrishnan, Heidi H. Gillenwater, MD, Tina Albertson, MD, Paul Guptill, Lauren F. Brown, Christopher G. Ramsborg, Ronald J. Hause, PhD, Ryan P. Larson, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 593.
https://doi.org/10.1182/blood-2019-127150
Published: 2019
Journal Articles

JCAR017 Is a Defined Composition CAR T Cell Product with Product and Process Controls That Deliver Precise Doses of CD4 and CD8 CAR T Cell to Patients with NHL

Free
Christopher G. Ramsborg, PhD, Paul Guptill, Clinton Weber, BS, Brian Christin, BS, Ryan P Larson, PhD, Kenneth Lewis, PhD, Mary Mallaney, Michael Bowen, PhD, Eileen Higham, PhD, Tina Albertson, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4471.
https://doi.org/10.1182/blood.V130.Suppl_1.4471.4471
Published: 2017
Journal Articles

Identification of Small Molecule Modulators to Enhance the Therapeutic Properties of Chimeric Antigen Receptor T Cells

Free
Jonathan Rosen, PhD, Betsy Rezner, BS, David Robbins, BS, Ian Hardy, PhD, Eigen Peralta, PhD, Christian Maine, PhD, Mohsen Sabouri, Sarah Reynal, Christopher Truong, Stacey Moreno, Heather Foster, Sarah Borchelt, Miguel Meza, MS, Lucas Thompson, Jason Fontenot, PhD, Ryan P Larson, PhD, Mirna Mujacic, PhD, Daniel Shoemaker, PhD
Journal: Blood
Blood (2016) 128 (22): 4712.
https://doi.org/10.1182/blood.V128.22.4712.4712
Published: 2016
Journal Articles

Functional Characterization of a T Cell Stimulation Reagent for the Production of Therapeutic Chimeric Antigen Receptor T Cells

Free
Keenan T Bashour, PhD, Ryan P Larson, PhD, Patricia Graef, PhD, Christian Stemberger, PhD, Germeroth Lothar, PhD, Valerie Odegard, PhD, Christopher G Ramsborg, PhD
Journal: Blood
Blood (2015) 126 (23): 1901.
https://doi.org/10.1182/blood.V126.23.1901.1901
Published: 2015
Journal Articles

Preclinical Analyses Support Clinical Investigation of Combined PD-L1 Blockade and Anti-CD19 CAR T Cell Therapy for the Treatment of NHL

Free
Ryan P Larson, PhD, Michael Ports, PhD, Heidi Jessup, Guadalupe Manriquez, MD, Carl Hay, Ross Stewart, PhD, Marlon Rebelatto, DVM, PhD, Robert Hollingsworth, PhD, Valerie Odegard, PhD
Journal: Blood
Blood (2015) 126 (23): 5430.
https://doi.org/10.1182/blood.V126.23.5430.5430
Published: 2015