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María Jose Mela Osorio
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Journal Articles

ONC001: A first-in-class ADC targeting CD64 for the treatment of monocytic leukemia developed through patient-guided target and payload selection

Free
Cintia Garro, Lia Buffa, Constanza Marin, Natalia Monjes, Agustina Garcia-Melani, Natalia Cavallo, Maria Drocchi, Diego Andino, Sofia Carbajosa, Laura Guantay, Alejandro Moyano, Maria Jarchum, Gustavo Jarchum, Pablo Garcia, Juan Garcia, Nicolás Cazap, Jorge Solimano, María Jose Mela Osorio, Isolda Fernandez, Miguel Pavlovsky, Carolina Pavlovsky, Alberto Giménez Conca, Erika Brulc, Silvina Palmer, Cecilia Ferrero, Gerardo Gatti, Tarek Zaki, Candelaria Llorens de los Rios, Alejandra García, Gail Roboz, Gastón Soria
Journal: Blood
Blood (2025) 146 (Supplement 1): 324.
https://doi.org/10.1182/blood-2025-324
Published: 2025
Journal Articles

Integrating cytokine profiles with clinical and molecular biomarkers to predict molecular relapse after TKI discontinuation in CML patients

Free
Carolina Pavlovsky, Bianca Vasconcelos Cordoba, Maria Sanchez, Elena Moiraghi, Ana Varela, Maria Custidiano, Miguel Pavlovsky, Isabel Giere, Federico Freilich, María Jose Mela Osorio, Isolda Fernandez, Ricardo Khalil Tannuri, Federico Sackmann, Mariana Juni, Eduardo Bullorsky, Georgina Bendek Del Prete, Juan Dupont, Maria Josefina Freitas, Veronica Ventriglia, Ana Garcia de Labanca, Romina Mariano, Carina Gumpel, Etelvina Macchiavello, Pedro Negri Aranguren, Mariano Paoletti, Francisca Rojas, Maria Fernanda Tosin, Marta Catalan, Julio Cesar Sanchez Avalos, Jose Mordoh, Estrella Levy, Michele Bianchini
Journal: Blood
Blood (2025) 146 (Supplement 1): 3785.
https://doi.org/10.1182/blood-2025-3785
Published: 2025
Journal Articles

Real-world insights into venetoclax and/or hypomethylating agent discontinuation in patients with Acute Myeloid Leukemia

Free
Rubén Gómez de Antonio, Helena Pomares, Guillermo Ramil López, Albert Cortés-Bullich, Diana Casares Aguiar, Miguel López-Esteban, Guadalupe Oñate, Carlos Jimenez-Vicente, Alberto Gimenez Conca, Carlos Rodríguez-Medina, Jorge Labrador, Alfredo Pacheco Reyes, Pilar Martinez Sanchez, Mar Tormo, Eduardo Rodríguez-Arbolí, Gonzalo Del Campo Balguerías, Carlos De Miguel, Joana Brioso Infante, María del Mar Moles Guerrero, Marta Cervera, Óscar Dominguez Muñiz, María Solé-Rodríguez, Irene Sanchez Vadillo, María Jiménez Moya, Ferran Vall-Llovera Calmet, Daniel Esteban, Maria Foncillas, Ana Lobo Olmedo, María Jose Mela Osorio, Merche Galiano, Gabriela Rodriguez Macias, Marina Díaz-Beyá, Ana Garrido, Pau Montesinos, Jordi Esteve, Anna Sureda Balarí, Montserrat Arnan
Journal: Blood
Blood (2025) 146 (Supplement 1): 5232.
https://doi.org/10.1182/blood-2025-5232
Published: 2025
Journal Articles

Assessing Molecular Relapse-Free Survival in Latin American Chronic Myeloid Leukemia Patients Undergoing TKI Dose Reduction

Free
Melina Gisel Luft, Ricardo Khalil Tannuri, María Jose Mela Osorio, Maria Elisa Riva, Beatriz Moiraghi, Ana Ines Varela, Ana Inés Prado, Veronica Ventriglia, Maria Josefina Freitas, Olivia Maria Gelo, Federico Sackmann Massa, Maria Fernanda Tosin, Mariel Ana Perez, Mariana Stevenazzi, Victoria Matosas, Carolina Barreto, Miguel Arturo Pavlovsky, Isolda Isabel Fernandez, Carolina Pavlovsky
Journal: Blood
Blood (2024) 144 (Supplement 1): 6620.
https://doi.org/10.1182/blood-2024-209195
Published: 2024
Journal Articles

Identification of Unexpected Responders to Gilteritinib in a Cohort of FLT3-WT AML Patients Using Ex-Vivo Testing

Free
Alejandra Garcia, Laura Bertoldi, Paula Scaglia, Sofia Carbajosa, Natalia Cavallo, Agustina Garcia-Melani, Laura Guantay, Marisa Piaggio, Gimena Ferreira, Maria Sol Jarchum, Gustavo Jarchum, Miguel Arturo Pavlovsky, Isolda Isabel Fernandez, María Jose Mela Osorio, Carolina Pavlovsky, Blanca Rossi, Martín Alonso, Juan José García, Nicolás Cazap, Jorge Solimano, Silvina Palmer, Adriana Rinflerch, Erika Barbara Brulc, Paula González Hermida, Alberto Gimenez Conca, Emilio Sarkotic, Andrea Arruda, Mark D. Minden, Virginia García, Federico Molineris, Maximiliano Zeballos, Maria Laura Bernaschini, Diego Andino, Agustina Conrrero, María Rita Drocchi, Tarek Ali Zaki, Gerardo Gatti, Candelaria Llorens, Gaston Soria
Journal: Blood
Blood (2023) 142 (Supplement 1): 7132.
https://doi.org/10.1182/blood-2023-181119
Published: 2023
Journal Articles

Long-Term Follow-up of the AST Trial of Treatment-Free Remission in Chronic Myeloid Leukemia Patients

Free
Ricardo K Tannuri, Beatriz Moiraghi, Ana Varela, Michele Bianchini, Miguel Arturo Pavlovsky, Georgina Bendek Del Prete, Maria Rosario Custidiano, Maria Josefina Freitas, Veronica Ventriglia, Eduardo Bullorsky, Pedro Negri Aranguren, Isolda Isabel Fernandez, Federico Sackmann Massa, Ana Garcia Labanca, Romina Mariano, Maria Fernanda Tosin, Juan Carlos Dupont, Francisca Rojas, Carina Gumpel, Etelvina Macchiavelo, Mariano Paoletti, Isabel Giere, Mariana Juni, Bianca Vasconcelos, Maria Belen Sanchez, Julio Cesar Sanchez Avalos, María Jose Mela Osorio, Carolina Pavlovsky
Journal: Blood
Blood (2023) 142 (Supplement 1): 6365.
https://doi.org/10.1182/blood-2023-189393
Published: 2023
Journal Articles

Functional Ex-Vivo Testing Combined with Machine Learning Predicts Clinical Response to Azacitidine+Venetoclax in AML

Free
Diego Andino, Maria Laura Bernaschini, Agustina Conrrero, María Rita Drocchi, Sofia Carbajosa, Alejandra Garcia, Isolda Isabel Fernandez, María Jose Mela Osorio, Miguel Arturo Pavlovsky, Carolina Pavlovsky, Silvina Palmer, Nicolás Cazap, Jorge Solimano, Adriana Rinflerch, Erika Barbara Brulc, Paula González Hermida, Andrea Arruda, Mark D. Minden, Gimena Ferreira, Marisa Piaggio, Tarek Ali Zaki, Gerardo Gatti, Candelaria Llorens, Gastón Soria
Journal: Blood
Blood (2023) 142 (Supplement 1): 2274.
https://doi.org/10.1182/blood-2023-187284
Published: 2023
Journal Articles

Impact of Ibrutinib in Quality of Life (QoL) in Patients with Chronic Lymphocytic Leukemia(CLL): Real World Experience in Argentina

Free
María Jose Mela Osorio, Astrid Pavlovsky, Carolina Pavlovsky, Isolda I Fernandez, Manuela Clavijo, Augusto Miroli, Federico Sackmann, Guillermina Remaggi, Luciana C Ferrari, Mariana Juni, Carolina Sighel, Maximiliano Riddick, Miguel Arturo Pavlovsky
Journal: Blood
Blood (2022) 140 (Supplement 1): 12403–12404.
https://doi.org/10.1182/blood-2022-165626
Published: 2022
Journal Articles

In Pursuit of Surrogate Markers for Treatment-Free Remission in Patients with Chronic Myeloid Leukemia from Argentina Stop Trial

Free
Maria Belen Sanchez, Beatriz Moiraghi, MD, Ana Ines Varela, MD, Estrella Levy, PhD, Masiel Vera, Bianca Vasconcelos Cordoba, Isabel Giere, PhD, Josefina Freitas, MD, Veronica Ventriglia, MD, Maria Del Rosario Custidiano, MD, Ana Garcia de Labanca, MD, Georgina Bendek, MD, Romina Mariano, MD, María Jose Mela Osorio, MD, Mariana Juni, Ms, Maximiliano Riddick, Miguel A. Pavlovsky, MD, Maria Cecilia Foncuberta, MD, Jose Mordoh, MD, Isolda I. Fernandez, MD, Julio Cesar Sanchez Avalos, MD, Carolina Pavlovsky, Michele Bianchini, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 24.
https://doi.org/10.1182/blood-2020-141067
Published: 2020
Journal Articles

High Level of Successful TKI Discontinuation in Chronic Myeloid Leukemia (CML) Patients: Preliminary Results of AST-Argentina Stop Trial

Free
Carolina Pavlovsky, Ana Ines Varela, MD, Isolda I. Fernandez, MD, Maria Belen Sanchez, Maria Del Rosario Custidiano, MD, Josefina Freitas, MD, Veronica Ventriglia, MD, Ana Garcia de Labanca, MD, Georgina Bendek, MD, Romina Mariano, MD, Estrella Levy, PhD, Masiel Vera, Isabel Giere, PhD, Bianca Vasconcelos Cordoba, María Jose Mela Osorio, MD, Miguel A. Pavlovsky, MD, Julio Cesar Sanchez Avalos, MD, Cecilia Foncouberta, MD, Mariana Juni, Ms, Maximiliano Riddick, Michele Bianchini, PhD, Beatriz Moiraghi, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–5.
https://doi.org/10.1182/blood-2020-142416
Published: 2020
Journal Articles

"M3-M6" Molecular Response Evolution As Early Predictor of Outcome Considering Generic Vs Branded TKIs for Chronic Myeloid Leukemia (CML): An Argentine Multicentric Study

Free
Isabel Amanda Giere, PhD M.Sc, María Jose Mela Osorio, MD, Federico Andrés Klosowski, Mariana Debus, Federico Sackmann, MD, Miguel A Pavlovsky, MD, Isolda Fernandez, MD, Elena Beatriz Moiraghi, MD, Ana Inés Varela, MD, Mariel Ana Perez, MD, Julio M. Pose Cabarcos, MD, Georgina Bendek, MD, Romina Mariano, MD, Silvina Palmer, MD, Alicia Enrico, MD, Isabel Cristina Annetta, MD, Andres L. Brodsky, MD PhD, Dante Intile, Statistic MD, Carolina Pavlovsky, MD
Journal: Blood
Blood (2016) 128 (22): 5445.
https://doi.org/10.1182/blood.V128.22.5445.5445
Published: 2016
Journal Articles

Results from a Hemato-Oncology Latin America Observational Registry (HOLA) Providing Real World Outcomes for the Treatment of Patients with NHL

Free
Miguel A Pavlovsky, MD, Laura Fogliatto, MD, Gladys Patricia Agreda Vásquez, MD, Alicia Enrico, MD, María Jose Mela Osorio, MD, Jorge Antonio Armenta San-Sebastian, MD, Roberto Ovilla, MD PhD, Oscar Avendaño, MD, Lineth López, MD, Telma Santos, MD PhD, Odin De La Mora Estrada, MD
Journal: Blood
Blood (2016) 128 (22): 5327.
https://doi.org/10.1182/blood.V128.22.5327.5327
Published: 2016
Journal Articles

Chronic Myeloid Leukemia (CML): BCR-ABL Transcript Levels Halving Time and Relative Reduction Ratio at Months 3 As New Predictors of Outcome. an Argentine Pilot Study

Free
Isabel Amanda Giere, PhD M.Sc, María Jose Mela Osorio, MD, Federico Andrés Klosowski, Mariana Debus, Ana Inés Varela, MD, Elena Beatriz Moiraghi, MD, Miguel A Pavlovsky, MD, Isolda Fernandez, MD, Dante Intile, Statistic, Carolina Pavlovsky, MD
Journal: Blood
Blood (2015) 126 (23): 1590.
https://doi.org/10.1182/blood.V126.23.1590.1590
Published: 2015
Journal Articles

Real-World Data from Long Term Follow-up in Chronic Myeloid Leukemia (CML) Patients (PTS) Treated with Imatinib. Predictive Factors for Achievement of Deep Molecular Responses and for Failure

Free
María Jose Mela Osorio, MD, Isabel Amanda Giere, PhD M.Sc, Isolda Fernandez, MD, Miguel A Pavlovsky, MD, Guillermina Remaggi, MD, Federico Sackmann, Dante Intile, Statistic, Carolina Pavlovsky, MD
Journal: Blood
Blood (2015) 126 (23): 5169.
https://doi.org/10.1182/blood.V126.23.5169.5169
Published: 2015