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Journal Articles

Novel Clinically Useful Inhibitor of Mediator Complex, RVU120, Relives Differentiation Block in MDS/AML

Free
Opeyemi Ajibade, Urszula Pakulska, Emma Rabinovich, Ariel Fromowitz, Srabani Sahu, Sarah Aminov, Nandini Ramachandra, Srinivas Aluri, Shanisha Gordon Mitchell, Milagros Carbajal, Kinga Keska-Izworska, Michał Combik, Marta Obacz, Elżbieta Adamczyk, Jan M. Zaucha, Ewa Zarzycka, Przemyslaw Juszczynski, Jacqueline Boultwood, Andrea Pellagatti, Kith Pradhan, Ulrich Steidl, Aditi Shastri, Rongbao Zhao, Milena Mazan, Tomasz Rzymski, Amit Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 3225.
https://doi.org/10.1182/blood-2023-186227
Published: 2023
Journal Articles

Multiomics Analysis Confirms Effective Target Engagement for RVU120 - a First-in-Class CDK8/19 Kinase Inhibitor in AML and MR-MDS Patients and Reveals the Mechanism of Action

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Tomasz Rzymski, Agnieszka Sroka-Porada, Magdalena Kozakowska, Urszula Głowniak-Kwitek, Karolina Bukowska-Strakova, Marta Obacz, Peter Littlewood, Kamil Kuś, Kristina Goller, Kinga Kęska, Urszula Pakulska, Kamila Kozłowska-Tomczyk, Monika Madej, Milena Mazan, Przemyslaw Juszczynski, Jan M. Zaucha, Agnieszka Zarzycka, Noemi Angelosanto, Hendrik Nogai, Krzysztof Brzózka
Journal: Blood
Blood (2022) 140 (Supplement 1): 5939–5940.
https://doi.org/10.1182/blood-2022-168906
Published: 2022
Journal Articles

RVU120 (SEL120) CDK8/19 Inhibitor - a Drug Candidate for the Treatment of MDS Can Induce Erythroid Differentiation

Free
Urszula Pakulska, Marta Obacz, Kristina Goller, Michal Combik, Kinga Keska, Jan Zaucha, Ewa Zarzycka, Milena Mazan, Michal Mikula, Magdalena Cybulska, Anna Polak, Przemyslaw Juszczynski, Johan Flygare, Jun Chen, Krzysztof Brzozka, Marcus Järås, Katarzyna Dziedzic, Noemi Angelosanto, Setareh Shamsili, Tomasz Rzymski
Journal: Blood
Blood (2021) 138 (Supplement 1): 1518.
https://doi.org/10.1182/blood-2021-150662
Published: 2021