Abstract

High-grade B-cell lymphoma with 11q aberration (HGBCL-11q) is a rare pediatric non-Hodgkin lymphoma. This study assessed outcome in 90 children with HGBCL-11q. With survival rates ≥95%, patients with HGBCL-11q and no predisposition are candidates for deescalated therapy in future prospective trials.

1.
Alaggio
R
,
Amador
C
,
Anagnostopoulos
I
, et al
.
The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms
.
Leukemia
.
2022
;
36
(
7
):
1720
-
1748
.
2.
Campo
E
,
Dierickx
D
,
Dirnhofer
S
, et al
.
Lymphoma classifications, how to develop a future unified taxonomy
.
J Clin Oncol
.
2024
;
42
(
27
):
3177
-
3182
.
3.
Zanelli
M
,
Sanguedolce
F
,
Zizzo
M
, et al
.
A diagnostic approach in large B-cell lymphomas according to the fifth World Health Organization and International Consensus Classifications and a practical algorithm in routine practice
.
Int J Mol Sci
.
2024
;
25
(
23
):
13213
.
4.
Xavier
AC
,
Attarbaschi
A
,
Gratzinger
D
,
Balagué
O
.
Dedicated diagnostic approaches for mature B-cell non-Hodgkin lymphomas occurring in children, adolescents, and young adults
.
Histopathology
.
2025
;
86
(
1
):
17
-
37
.
5.
Quintanilla-Martinez
L
,
Laurent
C
,
Soma
L
, et al
.
Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH Lymphoma Workshop
.
Virchows Arch
.
2023
;
483
(
3
):
281
-
298
.
6.
Salaverria
I
,
Martin-Guerrero
I
,
Wagener
R
, et al
.
A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma
.
Blood
.
2014
;
123
(
8
):
1187
-
1198
.
7.
Wagener
R
,
Seufert
J
,
Raimondi
F
, et al
.
The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma
.
Blood
.
2019
;
133
(
9
):
962
-
966
.
8.
Di Stefano
G
,
Fischer
A
,
Chteinberg
E
, et al
.
MicroRNA expression in high-grade B-cell lymphoma with 11q aberration
.
Genes Chromosomes Cancer
.
2025
;
64
(
1
):
e70021
.
9.
Au-Yeung
RKH
,
Arias Padilla
L
,
Zimmermann
M
, et al
.
Experience with provisional WHO-entities large B-cell lymphoma with IRF4 -rearrangement and Burkitt-like lymphoma with 11q aberration in paediatric patients of the NHL-BFM group
.
Br J Haematol
.
2020
;
190
(
5
):
753
-
763
.
10.
Gonzalez-Farre
B
,
Ramis-Zaldivar
JE
,
Salmeron-Villalobos
J
, et al
.
Burkitt-like lymphoma with 11q aberration: a germinal center-derived lymphoma genetically unrelated to Burkitt lymphoma
.
Haematologica
.
2019
;
104
(
9
):
1822
-
1829
.
11.
Elitzur
S
,
Shiloh
R
,
Loeffen
JLC
, et al
.
ATM germ line pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematological malignancies
.
Blood
.
2024
;
144
(
11
):
1193
-
1205
.
12.
Ferreiro
JF
,
Morscio
J
,
Dierickx
D
, et al
.
Post-transplant molecularly defined Burkitt lymphomas are frequently MYC-negative and characterized by the 11q-gain/loss pattern
.
Haematologica
.
2015
;
100
(
7
):
e275
-
e279
.
13.
Cairo
MS
.
A new Burkitt “look-alike” lymphoma
.
Blood
.
2019
;
133
(
9
):
889
-
891
.
14.
Jourdain
A
,
Auperin
A
,
Minard-Colin
V
, et al
.
Outcome of and prognostic factors for relapse in children and adolescents with mature B-cell lymphoma and leukemia treated in three consecutive prospective “Lymphomes Malins B” protocols. A Société Française des Cancers de l'Enfant study
.
Haematologica
.
2015
;
100
(
6
):
810
-
817
.
15.
Minard-Colin
V
,
Aupérin
A
,
Pillon
M
, et al
.
Rituximab for high-risk, mature B-cell non-Hodgkin’s lymphoma in children
.
N Engl J Med
.
2020
;
382
(
23
):
2207
-
2219
.
16.
Rigaud
C
,
Auperin
A
,
Jourdain
A
, et al
.
Outcome of relapse in children and adolescents with B-cell non-Hodgkin lymphoma and mature acute leukemia: a report from the French LMB study
.
Pediatr Blood Cancer
.
2019
;
66
(
9
):
e27873
.
17.
Rosolen
A
,
Perkins
SL
,
Pinkerton
CR
, et al
.
Revised international pediatric non-Hodgkin lymphoma staging system
.
J Clin Oncol
.
2015
;
33
(
18
):
2112
-
2118
.
18.
Tsurusawa
M
,
Mori
T
,
Kikuchi
A
, et al
.
Improved treatment results of children with B-cell non-Hodgkin lymphoma: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group B-NHL03 study
.
Pediatr Blood Cancer
.
2014
;
61
(
7
):
1215
-
1221
.
19.
Woessmann
W
,
Seidemann
K
,
Mann
G
, et al
.
The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95
.
Blood
.
2005
;
105
(
3
):
948
-
958
.
20.
Murphy
SB
.
Classification, staging and end results of treatment of childhood non-Hodgkin's lymphomas: dissimilarities from lymphomas in adults
.
Semin Oncol
.
1980
;
7
(
3
):
332
-
339
.
21.
Kim
JA
,
Kim
H-Y
,
Kim
SJ
,
Kim
HJ
,
Kim
SH
.
A case of Burkitt-like lymphoma with 11q aberration with HIV infection in East Asia and literature review
.
Ann Lab Med
.
2021
;
41
(
6
):
593
-
597
.
22.
Attarbaschi
A
,
Carraro
E
,
Abla
O
, et al
.
Non-Hodgkin lymphoma and pre-existing conditions: spectrum, clinical characteristics and outcome in 213 children and adolescents
.
Haematologica
.
2016
;
101
(
12
):
1581
-
1591
.
23.
Attarbaschi
A
,
Carraro
E
,
Ronceray
L
, et al
.
Second malignant neoplasms after treatment of non-Hodgkin's lymphoma-a retrospective multinational study of 189 children and adolescents
.
Leukemia
.
2021
;
35
(
2
):
534
-
549
.
24.
Attarbaschi
A
,
Abla
O
,
Arias Padilla
L
, et al
.
Rare non-Hodgkin lymphoma of childhood and adolescence: a consensus diagnostic and therapeutic approach to pediatric-type follicular lymphoma, marginal zone lymphoma, and nonanaplastic peripheral T-cell lymphoma
.
Pediatr Blood Cancer
.
2020
;
67
(
8
):
e28416
.
25.
Xavier
AC
,
Suzuki
R
,
Attarbaschi
A
.
Diagnosis and management of rare paediatric non-Hodgkin lymphoma
.
Best Pract Res Clin Haematol
.
2023
;
36
(
1
):
101440
.
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