B Cell Receptor Signalling Basics. Shown are the B cell receptor (BCR), the co-receptor CD19, and various signalling intermediates that are engaged following binding of the BCR to antigen. Several downstream pathways are ultimately triggered, as indicated. The asterisk indicates protein regions affected by recurrent somatic alterations in human lymphomas. See main text for details. BLNK, B-cell linker protein; BTK, Bruton tyrosine kinase; CARD11, caspase recruitment domain containing protein 11; CBM, CARD11–BCL-10–MALT1; CIN85, Cbl interacting protein of 85 kDa; DAG, diacylglycerol; IKK, inhibitor of NF-ΚB kinase; IgH, immunoglobulin heavy chain; IgL, immunoglobulin light chain; IP3, inositol trisphosphate; MALT1, mucosa-associated lymphoid tissue lymphoma translocation protein 1; MAPK, mitogen-activated protein kinase; mTOR, mammalian target of rapamycin; NF-ΚB, nuclear factor-ΚB; NFAT, nuclear factor of activated T cells; PI3K, phosphoinositide 3-kinase; PIP2, phosphatidylinositol-4,5-bisphosphate; PIP3, phosphatidylinositol-3,4,5- trisphosphate; PKCΒ, protein kinase CΒ; PLCγ, phospholipase Cγ; SFK, SRC family kinase.Reprinted with permission from Nat Rev Drug Discov. 2013;12:229-243.

B Cell Receptor Signalling Basics. Shown are the B cell receptor (BCR), the co-receptor CD19, and various signalling intermediates that are engaged following binding of the BCR to antigen. Several downstream pathways are ultimately triggered, as indicated. The asterisk indicates protein regions affected by recurrent somatic alterations in human lymphomas. See main text for details. BLNK, B-cell linker protein; BTK, Bruton tyrosine kinase; CARD11, caspase recruitment domain containing protein 11; CBM, CARD11–BCL-10–MALT1; CIN85, Cbl interacting protein of 85 kDa; DAG, diacylglycerol; IKK, inhibitor of NF-ΚB kinase; IgH, immunoglobulin heavy chain; IgL, immunoglobulin light chain; IP3, inositol trisphosphate; MALT1, mucosa-associated lymphoid tissue lymphoma translocation protein 1; MAPK, mitogen-activated protein kinase; mTOR, mammalian target of rapamycin; NF-ΚB, nuclear factor-ΚB; NFAT, nuclear factor of activated T cells; PI3K, phosphoinositide 3-kinase; PIP2, phosphatidylinositol-4,5-bisphosphate; PIP3, phosphatidylinositol-3,4,5- trisphosphate; PKCΒ, protein kinase CΒ; PLCγ, phospholipase Cγ; SFK, SRC family kinase.Reprinted with permission from Nat Rev Drug Discov. 2013;12:229-243.

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