Example HOD. The purpose of these marker states, or HODs, is to establish common definitions of patient-important outcomes to better inform the guideline panel’s decision-making by including definitions of the consequences for people in terms of symptoms, time horizon, testing and treatment, and consequences (eg, moderate symptomatic proximal DVT) (https://ms.gradepro.org/marker-states/ce16bfaf-cd4d-4138-9c06-1784e3a5413f).