Figure 2. PBN does not inhibit serum proinflammatory cytokine production. Lethally irradiated (1000 cGy) B6 mice received transplants of B6 BM cells and were then treated with either rat IgG (open bar; n = 6-11/group) or anti-CD40 antibody (8 μg/d) for 4 days beginning on day one after transplantation. Mice treated with anti-CD40 were administered either DMSO (shaded bar; n = 12-18/group) or PBN (solid bar; n = 12-19/group) for 5 days (days 0-4) after BMT. Mice were bled after completion of anti-CD40 administration (day 4) and analyzed for (A) IL-12, (B) IFN-γ, (C) TNF-α, and (D) nitrate/nitrite as described in “Study design.” Data are presented as the mean ± SEM and are the cumulative results from 2 to 4 independent experiments for each cytokine. P < .01, IgG versus DMSO, for IL-12, IFN-γ, TNF-α, and nitrate/nitrite; P = NS, DMSO versus PBN, for IL-12, IFN-γ, TNF-α, and nitrate/nitrite.
Figure 2.

PBN does not inhibit serum proinflammatory cytokine production. Lethally irradiated (1000 cGy) B6 mice received transplants of B6 BM cells and were then treated with either rat IgG (open bar; n = 6-11/group) or anti-CD40 antibody (8 μg/d) for 4 days beginning on day one after transplantation. Mice treated with anti-CD40 were administered either DMSO (shaded bar; n = 12-18/group) or PBN (solid bar; n = 12-19/group) for 5 days (days 0-4) after BMT. Mice were bled after completion of anti-CD40 administration (day 4) and analyzed for (A) IL-12, (B) IFN-γ, (C) TNF-α, and (D) nitrate/nitrite as described in “Study design.” Data are presented as the mean ± SEM and are the cumulative results from 2 to 4 independent experiments for each cytokine. P < .01, IgG versus DMSO, for IL-12, IFN-γ, TNF-α, and nitrate/nitrite; P = NS, DMSO versus PBN, for IL-12, IFN-γ, TNF-α, and nitrate/nitrite.

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