Marked T-cell skewing in liver-infiltrating lymphocytes of HAA and hepatitis patients. Skewing was observed in HAA patients (n = 7) and hepatitis patients (n = 4). ▪ indicates the skewing V_β profile by observation and RI; ▨ indicates the normal V_β profile; and □ indicates no detectable signal. Overall, there were 60% ± 17% skewed spectratypes, with 5% ± 12% absent spectratypes in the HAA patients, compared with 67% ± 0% skewed V_β's, with no signal in 11% ± 13% of reactions, in the viral hepatitis patients. Thus, no significant difference was shown in the number of skewed V_β spectratypes in each group (P > .5).