Figure 3. PT-100 accelerates recovery of mice from hemolytic anemia. Acute hemolytic anemia was induced by intraperitoneal injection of PHZ (60 mg/kg) on days 0 and 1. Five micrograms PT-100 or saline was administered orally and twice daily to BALB/c mice for a 5-day period before PHZ treatment (ie, from day–6today–2). (A) Changes in hematocrit in mice pretreated with saline (○) or PT-100 (•). Horizontal bar indicates hematocrits of normal mice. (B) Changes in reticulocytes in mice pretreated with saline (○) or PT-100 (•). (C) Levels of splenic CFU-Es (×10–4; ▪) and BFU-Es (×10–3; □) on day 3 in mice treated with saline or PT-100 as indicated on abscissa. CFUs were assayed as described in “Materials and methods.” Data are expressed as the mean ± SD of 3 mice/group using discrete groups for each point in time, and they are representative of 2 independent experiments. Significant P values are indicated in “Results.”
Figure 3.

PT-100 accelerates recovery of mice from hemolytic anemia. Acute hemolytic anemia was induced by intraperitoneal injection of PHZ (60 mg/kg) on days 0 and 1. Five micrograms PT-100 or saline was administered orally and twice daily to BALB/c mice for a 5-day period before PHZ treatment (ie, from day–6today–2). (A) Changes in hematocrit in mice pretreated with saline (○) or PT-100 (•). Horizontal bar indicates hematocrits of normal mice. (B) Changes in reticulocytes in mice pretreated with saline (○) or PT-100 (•). (C) Levels of splenic CFU-Es (×10–4; ▪) and BFU-Es (×10–3; □) on day 3 in mice treated with saline or PT-100 as indicated on abscissa. CFUs were assayed as described in “Materials and methods.” Data are expressed as the mean ± SD of 3 mice/group using discrete groups for each point in time, and they are representative of 2 independent experiments. Significant P values are indicated in “Results.”

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