p14^ARF overexpression as a marker of aggresivity.

(A) Kaplan-Meier analysis: overall survival curves showing a shorter survival in cases with p14^ARF nuclear overexpression compared with the rest of the series. (B) Relative frequency of abnormal p14^ARF overexpression as a function of cell cycle status. Cases are grouped according to the number of simultaneous alterations in major tumor suppressors (p53, p16^INK4a, p27^KIP1). Nuclear p14^ARF overexpression becomes more frequent as the number of alterations increases.