Fig. 7. Comparison of the homologous domains in the flanking regions of the PBP/PF4 locus. / A comparison of the conserved regions, other than within the coding areas or the immediate 1.0 kb of 5′-flanking region, of the mouse and human PBP and PF4 genes are shown. A “‖” refers to an identical nucleotide. Consensus DNA binding sites for a number of megakaryocyte-specific transcriptional factors are highlighted and the names of the transcriptional factors and their orientations are shown. Panel A represents the conserved domain upstream of the PBP gene, and negative numbering begins at the PBP transcriptional start site.11 Panel B represents the conserved intergenic region, and negative numbering begins at the PF4 transcriptional start site.10 Panel C represents the conserved region downstream of the PF4 gene, and numbering begins at the PF4 transcriptional start site.
Fig. 7.

Comparison of the homologous domains in the flanking regions of the PBP/PF4 locus.

A comparison of the conserved regions, other than within the coding areas or the immediate 1.0 kb of 5′-flanking region, of the mouse and human PBP and PF4 genes are shown. A “‖” refers to an identical nucleotide. Consensus DNA binding sites for a number of megakaryocyte-specific transcriptional factors are highlighted and the names of the transcriptional factors and their orientations are shown. Panel A represents the conserved domain upstream of the PBP gene, and negative numbering begins at the PBP transcriptional start site.11 Panel B represents the conserved intergenic region, and negative numbering begins at the PF4 transcriptional start site.10 Panel C represents the conserved region downstream of the PF4 gene, and numbering begins at the PF4 transcriptional start site.

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