Schematic representation of the cytoplasmic domains of 4 SLAM family members.

SAP has been shown to bind preferentially to a consensus binding motif: T (I/V)Y x x (V/I), where x represents any amino acid. The cytoplasmic domains of the SLAM family members SLAM, 2B4, Ly9, and CD84 contain multiple SAP-binding motifs. Lines indicate the cytoplasmic domain of the SLAM family members. Blocks represent real (*) or putative SAP-binding motifs. Blocks labeled with # are putative motifs proven to be unable to bind SAP, whereas those without marks have not been tested for SAP binding.