Fig. 4. The putative mechanism of cell cycle exit in APL cells upon the effect of ATRA. / p21WAF1/CIP1 may function at the upstream differentiation program initiation. Members of the CEBP family, such as CEBP-ε and GADD153 (CHOP), may stabilize the p21WAF1/CIP1 protein from degradation in the current context. The additional member of this family, CEBP-α, has been reported to be implicated in the differentiation of preadipocytes through posttranscriptional stabilization of the p21WAF1/CIP1 protein (left). Additionally, activation of the cell cycle exit and apoptosis-resistant pathways appears to be the prerequisite for the initiation of the differentiation program.
Fig. 4.

The putative mechanism of cell cycle exit in APL cells upon the effect of ATRA.

p21WAF1/CIP1 may function at the upstream differentiation program initiation. Members of the CEBP family, such as CEBP-ε and GADD153 (CHOP), may stabilize the p21WAF1/CIP1 protein from degradation in the current context. The additional member of this family, CEBP-α, has been reported to be implicated in the differentiation of preadipocytes through posttranscriptional stabilization of the p21WAF1/CIP1 protein (left). Additionally, activation of the cell cycle exit and apoptosis-resistant pathways appears to be the prerequisite for the initiation of the differentiation program.

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