Kaplan-Meier curves and multivariable analysis. (A) Ten-year arterial and venous/splanchnic thrombosis-free curves from MPN diagnosis in cases (Ca) and controls (Co). (B) Effect of arterial and venous/splanchnic thrombosis on risk of second cancer (SC) obtained by a multivariable conditional logistic regression model, adjusted for potential confounders (age, cardiovascular risk factors, JAK2 mutation, and time of thrombosis at diagnosis or during follow-up) and stratified by type of second cancer. Because of the low number of cases, no multivariable model was fitted for melanoma. HSC, hematological second cancer; NM, nonmelanoma.