Labeled pooled clones revealed clonal instability during serial transplantation. The average frequency of CFP-, YFP-, RFP-, or GFP-labeled pooled clones in the PB at 4 (A) and 16 (B) weeks and in MPPs at 16 weeks (C) and HSCs (D) at 16 weeks throughout transplantation. Results are shown for each transplanted group (#A-F). Related to Figure 5. Whisker plots show the interquartile range; n ≥ 5 for each transplanted mouse cohort (see supplemental Figure 5 for the distribution of all pooled clones). Source data are provided in supplemental Table 1.