Fig. 3. Evidence for ongoing mutation in MedB-1 cells. / Seven PCR clones amplified from MedB-1 cells were aligned and compared with the most homologous germline IgVH sequence V4-39 from codons 86 through 92. Sequence homologies between V4-39 and the consensus sequence of the PCR clones are highlighted by asterisks. Dashes designate identities among PCR clones. Clones 3 and 6 show deviations from the consensus sequence in codons 87 and 91, suggesting ongoing somatic mutation.
Fig. 3.

Evidence for ongoing mutation in MedB-1 cells.

Seven PCR clones amplified from MedB-1 cells were aligned and compared with the most homologous germline IgVH sequence V4-39 from codons 86 through 92. Sequence homologies between V4-39 and the consensus sequence of the PCR clones are highlighted by asterisks. Dashes designate identities among PCR clones. Clones 3 and 6 show deviations from the consensus sequence in codons 87 and 91, suggesting ongoing somatic mutation.

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