Figure 7. PMP-transferred miR-24 inhibits mitochondrial function in tumor cells. (A) cDNA from RNA isolated from mitochondria (Mito), nucleolar (No), nuclear (Nu), and postmitochondria (Cyto) fractions of untreated and PMP-treated LLC cells (−/+) was subject to PCR for the indicated genes. (B) Mitochondrial membrane potential (TMRM, left) and ATP levels (right) were assessed in LLC cells ± PMPs and antagomiR-24 as indicated. (C) TMRM (left) and ATP (right) in MC-38 cells, treated as in panel B. *P < .01; **P < .0001 (n = 3). All histograms, shown ± SEM. RLU, relative luminescence unit.
Figure 7.

PMP-transferred miR-24 inhibits mitochondrial function in tumor cells. (A) cDNA from RNA isolated from mitochondria (Mito), nucleolar (No), nuclear (Nu), and postmitochondria (Cyto) fractions of untreated and PMP-treated LLC cells (−/+) was subject to PCR for the indicated genes. (B) Mitochondrial membrane potential (TMRM, left) and ATP levels (right) were assessed in LLC cells ± PMPs and antagomiR-24 as indicated. (C) TMRM (left) and ATP (right) in MC-38 cells, treated as in panel B. *P < .01; **P < .0001 (n = 3). All histograms, shown ± SEM. RLU, relative luminescence unit.

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