Figure 3. Bleeding mortality associated with cell-mediated thrombocytopenia is weaker than that of antibody-mediated thrombocytopenia. Kaplan-Meier survival plots of irradiated SCID mice transferred with (A) 5 × 104 nondepleted immune splenocytes from CD61 KO mice immunized against BALB/c platelets (n = 15) or 5 × 104 immune splenocytes depleted of either (B) CD4+ T cells (n = 15), (C) CD8+ T cells (n = 18), or (D) CD19+ B cells (n = 14). The data are expressed as the percentage of survival and calculated from the mouse groups in Figure 2.
Figure 3

Bleeding mortality associated with cell-mediated thrombocytopenia is weaker than that of antibody-mediated thrombocytopenia. Kaplan-Meier survival plots of irradiated SCID mice transferred with (A) 5 × 104 nondepleted immune splenocytes from CD61 KO mice immunized against BALB/c platelets (n = 15) or 5 × 104 immune splenocytes depleted of either (B) CD4+ T cells (n = 15), (C) CD8+ T cells (n = 18), or (D) CD19+ B cells (n = 14). The data are expressed as the percentage of survival and calculated from the mouse groups in Figure 2.

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