Figure 3. Effect of protein S and protein S-C4BP on thrombin generation in factor VIII–neutralized plasma factor VLeiden plasma. (A) Thrombin generation in factor VLeiden plasma was measured without APC (▲), with 30 nM APC (△), with 30 nM APC and 1.87 μM antibodies against protein S (○) and 30 nM APC and 500 nM protein S-C4BP (●), and with 30 nM APC, 500 nM protein S-C4BP, and 1.87 μM antibodies against protein S (■). (B) Thrombin generation in factor VIII–neutralized factor VLeiden plasma was measured without APC (▲), with 30 nM APC (△), with 30 nM APC and 1.87 μM antibodies against protein S (○) and 30 nM APC and 500 nM protein S-C4BP (●).
Figure 3

Effect of protein S and protein S-C4BP on thrombin generation in factor VIII–neutralized plasma factor VLeiden plasma. (A) Thrombin generation in factor VLeiden plasma was measured without APC (▲), with 30 nM APC (△), with 30 nM APC and 1.87 μM antibodies against protein S (○) and 30 nM APC and 500 nM protein S-C4BP (●), and with 30 nM APC, 500 nM protein S-C4BP, and 1.87 μM antibodies against protein S (■). (B) Thrombin generation in factor VIII–neutralized factor VLeiden plasma was measured without APC (▲), with 30 nM APC (△), with 30 nM APC and 1.87 μM antibodies against protein S (○) and 30 nM APC and 500 nM protein S-C4BP (●).

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