Nucleotide changes for the discovery set of de novo AML samples. Nonsynonymous nucleotide changes and gene deletions or insertions are highlighted in red; white boxes indicate missing sequence data. Known SNPs are excluded from this analysis. Both leukemia (T) and germline (G) samples for each patient were sequenced. ITD indicates internal tandem duplication (FLT3); INS, tetranucleotide insertion of exon 12 (NPM1).