Results expressed as countsper minute (CPM). Pt 1 MLR was performed day + 101 post-transplant. (T-cell chemerism was 100% cord). The alloreactiveresponse to the haploidentical donor is seven fold higher than the response to HLA-mismatched 3rd party, suggesting, there is rejecttion of the haploid donor by the cordunit. In Pt 2. the cord unit failed to engraft, the MLR was performed on day +99 (T-cell chimerism 100% recipient, myeloid 99% hapolied donor). The alloreactiver esponse to the haploid donor was similar to the response to self. suggestomg tolerance. In pt 3. thee MLR was performed day +63 post-transplant (T-cell chimerism 79% cord. 22% recipient; Myeloid Chimerism 100% haploid donor). There is a trend to wards a greater alloreactive response against haploid donor compared to 3rd party, suggesting early rejection.
