Figure 5. Effect of HSC genotype and age on thymic involution. (A) Thymic cellularity 12 months after reciprocal transplants between wt and Tgfb2+/- (het) mice (mean ± SEM, n = 3-5 mice from 3 separate transplantation experiments; *significantly different from het→het transplants). (B) Correlation between the fraction of naive (CD44lowCD45RB+) CD4 cells in the peripheral blood and thymic cellularity in the transplant recipients of panel A for which data were available (n = 18). (C) Effect of the age of reconstituting bone marrow cells on thymic cellularity 12 months after transplantation (mean ± SEM; n = 10 for recipients of bone marrow of aged mice; n = 7 for recipients of bone marrow from young mice).
Figure 5.

Effect of HSC genotype and age on thymic involution. (A) Thymic cellularity 12 months after reciprocal transplants between wt and Tgfb2+/- (het) mice (mean ± SEM, n = 3-5 mice from 3 separate transplantation experiments; *significantly different from het→het transplants). (B) Correlation between the fraction of naive (CD44lowCD45RB+) CD4 cells in the peripheral blood and thymic cellularity in the transplant recipients of panel A for which data were available (n = 18). (C) Effect of the age of reconstituting bone marrow cells on thymic cellularity 12 months after transplantation (mean ± SEM; n = 10 for recipients of bone marrow of aged mice; n = 7 for recipients of bone marrow from young mice).

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