Longitudinal patterns of pirtobrutinib resistance. (A) Timeline showing BTK mutations detected at multiple time points in 67 PD patients with available intermediate time points. (B) VAF at multiple time points in 13 patients with acquired BTK mutations detected in time points collected before PD.

Longitudinal patterns of pirtobrutinib resistance. (A) Timeline showing BTK mutations detected at multiple time points in 67 PD patients with available intermediate time points. (B) VAF at multiple time points in 13 patients with acquired BTK mutations detected in time points collected before PD.

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