Figure 1.
Measurements in highlanders. Participants diagnosed with CMS (n = 6) had paired measurements taken before (CMS pre) and 48 hours after IVHD (CMS post). The remaining participants (n = 8) were classified as non-CMS. (A) Hematocrit measured in duplicate after spinning blood collected by finger prick. (B) Blood volume measured by using the indocyanine green (CardioGreen) dye dilution method.25 (C-D) Plasma (C) and RBC volumes (D) calculated from blood volume and hematocrit. (E) Alveolar PO2 calculated from the alveolar gas equation (PAO2 = PIO2 – PaCO2 /R + PaCO2 × FIO2 × [1 – R]/R). (F) Arterial PO2 measured by arterial blood gas (ABG) analysis (iSTAT; Abbott Point of Care Inc). (G) Arterial oxygen saturation (SaO2) measured directly by whole blood CO-oximetry (AVOXimeter 4000; Instrumentation Laboratory). (H) Arterial oxygen content calculated from hemoglobin concentration, SaO2, and dissolved oxygen. (I) CMS score determined by Qinghai CMS questionnaire. (J) Resting cardiac output (QT) measured by impedance cardiography (PhysioFlow Enduro) by means of 6 electrodes taped onto cleansed skin (2 each on the back, neck, and chest). (K) Whole-body oxygen consumption (VO2) and minute ventilation (VE) measured in parallel by breath-by-breath gas exchange analysis and bidirectional digital turbine flowmeter, respectively (Quark CPET; COSMED). (L) Serum EPO measured by automated, chemiluminescent immunoassay. Normality of distribution and homogeneity of variance were assessed for comparison between groups. Unpaired or paired Student or Wilcoxon tests were applied accordingly to evaluate differences between (1) participants without CMS and those with CMS before IVHD; (2) participants without CMS and those with CMS after IVHD; and (3) participants with CMS before and after IVHD. Bonferroni correction for multiple comparisons was applied to account for the dual use of each group (ie, participants without CMS compared with both participants with CMS before and after IVHD; participants with CMS before and after IVHD compared with each other).

Measurements in highlanders. Participants diagnosed with CMS (n = 6) had paired measurements taken before (CMS pre) and 48 hours after IVHD (CMS post). The remaining participants (n = 8) were classified as non-CMS. (A) Hematocrit measured in duplicate after spinning blood collected by finger prick. (B) Blood volume measured by using the indocyanine green (CardioGreen) dye dilution method.25 (C-D) Plasma (C) and RBC volumes (D) calculated from blood volume and hematocrit. (E) Alveolar PO2 calculated from the alveolar gas equation (PAO2 = PIO2 – PaCO2 /R + PaCO2 × FIO2 × [1 – R]/R). (F) Arterial PO2 measured by arterial blood gas (ABG) analysis (iSTAT; Abbott Point of Care Inc). (G) Arterial oxygen saturation (SaO2) measured directly by whole blood CO-oximetry (AVOXimeter 4000; Instrumentation Laboratory). (H) Arterial oxygen content calculated from hemoglobin concentration, SaO2, and dissolved oxygen. (I) CMS score determined by Qinghai CMS questionnaire. (J) Resting cardiac output (QT) measured by impedance cardiography (PhysioFlow Enduro) by means of 6 electrodes taped onto cleansed skin (2 each on the back, neck, and chest). (K) Whole-body oxygen consumption (VO2) and minute ventilation (VE) measured in parallel by breath-by-breath gas exchange analysis and bidirectional digital turbine flowmeter, respectively (Quark CPET; COSMED). (L) Serum EPO measured by automated, chemiluminescent immunoassay. Normality of distribution and homogeneity of variance were assessed for comparison between groups. Unpaired or paired Student or Wilcoxon tests were applied accordingly to evaluate differences between (1) participants without CMS and those with CMS before IVHD; (2) participants without CMS and those with CMS after IVHD; and (3) participants with CMS before and after IVHD. Bonferroni correction for multiple comparisons was applied to account for the dual use of each group (ie, participants without CMS compared with both participants with CMS before and after IVHD; participants with CMS before and after IVHD compared with each other).

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal