α-KG supplementation rewires BCAA metabolism to deplete amino acids like leucine. Amino acid deprivation inactivates mTORC1 by perturbing lysosomal localization that contributes to suppression of lymphoma growth. The model does not reflect actual subcellular localization of metabolites. BCAA, branched-chain amino acid; BCKA, branched-chain keto acids. The figure was created using BioRender.com.