FVIII activity and spontaneous bleeds phenotype of F8em1−/− mice. (A) FVIII activity of age-matched male WT, F8tm1Kaz−/−, and F8em1−/− mice, measured using the FVIII:C activity assay. Data display individual animals and group mean ± standard error of the mean (SEM); n = 4 to 16 mice per group. Statistical analysis was conducted using analysis of variance (ANOVA) and the Tukey multiple comparison test; ∗∗∗∗P ≤ .0001. (B) Hct in age-matched male WT, F8tm1Kaz−/− mice and F8em1−/− mice without or with overt bleeds. Data display individual animals and group mean ± SEM (n = 19-32 mice per group). Statistical analysis was conducted using ANOVA and the Tukey multiple comparison test; ∗∗∗P ≤ .001. (C) Kaplan-Meier survival curve for male mice from birth to 200 days to display the survival (percent) of 150 F8em1−/− and 150 F8tm1Kaz−/− mice. Log-rank (Mantel-Cox) test was used for survival analysis; ∗∗P ≤ .01. ns, nonsignificant.
Figure 1.

FVIII activity and spontaneous bleeds phenotype of F8em1−/− mice. (A) FVIII activity of age-matched male WT, F8tm1Kaz−/−, and F8em1−/− mice, measured using the FVIII:C activity assay. Data display individual animals and group mean ± standard error of the mean (SEM); n = 4 to 16 mice per group. Statistical analysis was conducted using analysis of variance (ANOVA) and the Tukey multiple comparison test; ∗∗∗∗P ≤ .0001. (B) Hct in age-matched male WT, F8tm1Kaz−/− mice and F8em1−/− mice without or with overt bleeds. Data display individual animals and group mean ± SEM (n = 19-32 mice per group). Statistical analysis was conducted using ANOVA and the Tukey multiple comparison test; ∗∗∗P ≤ .001. (C) Kaplan-Meier survival curve for male mice from birth to 200 days to display the survival (percent) of 150 F8em1−/− and 150 F8tm1Kaz−/− mice. Log-rank (Mantel-Cox) test was used for survival analysis; ∗∗P ≤ .01. ns, nonsignificant.

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