Kaplan-Meier analysis of overall survival and leukemia-free survival in patients with MDS belonging to the del(5q) group of the molecular taxonomy, subdivided into distinct subsets. (A) Patients with truly isolated del(5q) (as indicated by the absence of any additional chromosomal abnormality or somatic gene mutation) vs patients with at least 1 co-occurring genetic lesion. (B) Patients with truly isolated del(5q) vs those with an SF3B1 comutation. (C) Patients with truly isolated del(5q) vs those with RUNX1 comutation. P values are from the log-rank test.